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Connor A. Jacobson personal email
Having begun my professional career at Harvard Medical School in 2015, I have sharpened my scientific repertoire working with some of the leading expert scientists, doctors, pathologists, clinicians, and principal investigators on projects ranging from various cancers to COVID-19 and many maladies in between. With an emphasis on cancer microscopy, I have established myself as one of the leading high-throughput multiplexed imaging microscopists in the field. With over six years of experience with cyclic immunofluorescence (CyCIF), I have recently begun to adapt Codex multiplexed staining and high-throughput imaging using the novel Fusion scanner at BostonGene Corp where I began working in January 2022. With such elevated throughput and plexity, we can characterize, describe, and investigate the tumor microenvironment (TME), cell-to-cell interactions, cluster like and unalike cell populations, spatial relations, and more using leading and advancing technology. It is my responsibility and goal to produce highly actionable data that can elucidate individualized cancer phenotypes and share this information with pathologists and clinicians to help lead to precision medicine. My primary duties at BostonGene are to acquire multiplex images of tumors, profile the results, and improve experimental, imaging, and analytical pipelines through the generation of actionable data. Lauded for my enthusiastic collaborative nature, easy-going personality, and incomparable data collection, I have positioned myself well to continue to share and grow my knowledge as it pertains to oncology, immunology, pathology, and microscopy. Ideally, over the coming years, I will continue to advance myself as a scientist and scientific thinker, share and culture my expertise, and contribute to scientific and medical research that will enhance the lives of many. I have a penchant for learning and a curiosity that cannot be satiated -- I look forward to contributing to and learning from a rapidly growing and evolving field.
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Program Alliance ManagerBostongeneBoston, Ma, Us -
ScientistBostongene Jan 2024 - PresentWaltham, Massachusetts, United States -
Principal Research AssociateBostongene Jan 2022 - Jan 2024Massachusetts, United StatesBringing vast knowledge of the multi-plexed imaging world of cancer immunology staining, I was brought on board at BostonGene to share my knowledge and expertise in areas ranging from antibody panel construction to creating SOPs and standardizations of reagent inventorying and cataloging. Working in a highly collaborative environment comprised of three mains pillars of scientific research: imaging, sequencing, and flow cytometry, our company aims to bring together these disciplines to create a full Tumor Portrait that can be shared between clinicians and patients. By unearthing findings related to these three main pillars, we aim to provide a complete diagnostic to one's individualized tumor. With a focus on multi-plexed imaging, it is my role to characterize and phenotype clusters of different cell populations and share these findings with the team. -
Research AssociateHarvard Medical School Aug 2015 - Jan 2022Greater Boston AreaWorking in both the Laboratory of Systems Pharmacology and the Lab of Dr. Peter Sorger, I have been afford many opportunities to work with many collaborators on a variety of novel projects. With a penchant for microscopy, my main responsibilities include working with Principal Investigators, clinicians, pathologists, PostDocs, and graduate students to address their biological questions pertaining to various cancers through deeply phenotyping tumor embedded in FFPE. Employing an iterative immunofluoresence assay, known as CyCIF (developed in our lab), I perform high-throughput, multi-plexed microscopy directly on tissue section, staining for up to 60 markers/antibodies, to help characterize tumor, tumor-microenvironments, and immune response. By defining tumors and tissue at a single-cell level, we can better understand the composition of disease and parlay this information to support precision medicine. Once initial findings are digested at a lower resolution, we can characterize cell-to-cell interaction(s) via high-resolution microscopy on a DeltaVision 7 instrument.Having collaborated and contributed to publications involving ovarian cancer, breast cancer, lung cancer, and skin cancers, the scope of my research extends to bone marrow, attenuated tuberculosis, and even COVID-19, working first with section of rhesus macaque lung and trachea tissue and ultimately human autopsies. Our preliminary findings, involving differential immune response correlated to SARS-CoV-2 viral-load in macaques was extended to human studies and our work contributed towards the formulation of the Johnson and Johnson vaccine.Having been lauded for my tremendous communication skills, I look forward to transitioning to the biotech and pharmaceutical industries where my technical and interpersonal skills can contribute and enhance ground-breaking scientific advancements. -
Research AssistantMassachusetts Institute Of Technology (Mit) May 2014 - Sep 2014Longwood Medical AreaAs a Research Assistant I worked with professionals, PhD candidates, graduate and undergraduate students, exploring the nature of immunology and how high-fat diets affect stem cell formation in laboratory mice. Working at the Karp Laboratory of Boston's Children's Hospital and MIT's Koch Institute, I was afforded access to top-of-the-line technologies for vital research at two world-renowned research institutions. Working under Principle Investigator Omer Yilmaz, following multiple laboratory protocols and rigorous training, has prepared me for a Research Technician position or similar job after graduation. Specific responsibilities and experience:• Determined the differences between high fat and control diets in mice and how they can affect the amount of stem cell formation in mice intestinal crypts. Dissected, euthanized, and attended to mice, while recording and analyzing housing, birth, and species data.• Collaborated with professionals, PhD candidates, and other graduate students in exploring the relationship between a long-term high-fat diet and the onset of intestinal cancer. Identified multiple signal transduction pathways (specifically wnt) and other activated components affecting tumorgenesis in cultivated crypts.• Utilized techniques such as Western Blotting, gel electrophoresis, DNA membrane preparations, genotyping, cell culture, FACS, and qPCR to analyze animal DNA in hopes of uncovering novel approaches to manipulate protein expression in mice.• Attended weekly classes at Harvard Medical School for both undergraduates and MD/PhD students addressing current issues in immunology and the emerging field of neuro-immunology. Networked with esteemed faculty and researchers to discuss modern discoveries and applicable work to our own research. Classes and work included weekly workshops and scientific journal clubs.At the end of the summer I presented a poster presentation summarizing my work to Harvard Medical School faculty. -
Undergraduate Research AssistantTrinity College Jan 2014 - May 2014Hartford, Connecticut AreaPerformed research with a Neuroscience/Psychology professor Elizabeth Casserly in understanding the comprehension of language differences when presented with auditory stimuli. The stimuli are either normal speakers' voice recording or are recording while the speakers are wearing a cochlear implant vocoder. As a Research Assistant, I was responsible for research design and analysis, experimental design using E-Prime, the physical acoustic set-up of the laboratory, finding and recruiting participants, and running participants through their tasks. Selected as one of three students to work in the lab during its first year. Future results are to benefit the field of linguistics and how CI's function. -
Graduate Research AssistantTrinity College - Hartford Jan 2014 - May 2014Hartford, Connecticut AreaAs an undergraduate student, I was selected as one of two students to be a part of an additional graduate level correlate of a Philosophy course titled "Minds and Brains." I was able to take the class at the undergraduate level but also performed research at the graduate level; the class is listed a graduate credit. In addition to the regular undergraduate duties, another student and I worked with Dan Lloyd to study specific regions activated in the brain when participants are presented with an auditory stimulus of the movie "Forrest Gump." The participants watch the entirety of "Forrest Gump" without any visual stimulation. My responsibilities as a research assistant were to figure out and understand why certain areas of the brain are activated, and how firing action potentials correlated with specific parts of the movie. We submitted our data and results to the original experimenters as further developments of their original study. -
Discovery Pharmaceutics InternCubist Pharmaceuticals May 2013 - Aug 2013Lexington, Ma• Developed a high-throughput lyophilization formulation platform and plate map to support multiple discovery projects.• Interpreted and collected the data generated by lyophilizer . • Organized data in an Excel database -- which I had created and revamped -- with other Cubist compounds arranged by their physiochemical properties and relevant physiochemical characteristics.• Ran procedures using various lab techniques associated with the analysis of oral and parenteral dosage forms such as lyophilization, HPLC, DSC, TGA, XRPD, solubility, and UV spectrophotometer.• Prepared stock solutions, buffers, and dosing formulations.• Worked in both small and large group collaborations. Exposed to wide range of company activities through organized seminars and meetings including with President and CEO.
Connor A. Jacobson Skills
Connor A. Jacobson Education Details
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Biology; Immuno-Onocology
Frequently Asked Questions about Connor A. Jacobson
What company does Connor A. Jacobson work for?
Connor A. Jacobson works for Bostongene
What is Connor A. Jacobson's role at the current company?
Connor A. Jacobson's current role is Program Alliance Manager.
What is Connor A. Jacobson's email address?
Connor A. Jacobson's email address is co****@****ard.edu
What schools did Connor A. Jacobson attend?
Connor A. Jacobson attended Harvard Extension School, Trinity College-Hartford.
What skills is Connor A. Jacobson known for?
Connor A. Jacobson has skills like Public Speaking, Social Media, Powerpoint, Microsoft Office, Microsoft Word, Spanish, Neuroscience, Microsoft Excel, Research, Organizational Leadership, Laboratory Skills, Group Work.
Who are Connor A. Jacobson's colleagues?
Connor A. Jacobson's colleagues are Ulyana Chaban, Desyana Martinez, Anastasiia Shvyrkova, Levon Abgaryan, Anna Kamysheva, Basim Salem, Sergei Volkov.
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