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Conor Howard is listed as DMS for Drug Discovery at Octant, based in San Francisco Bay Area, United States, United States. AeroLeads shows a work email signal at octant.bio and a matched LinkedIn profile for Conor Howard.
Conor Howard previously worked as Project Lead at Octant and Alliances Manager at Octant. Conor Howard holds Doctor Of Philosophy - Phd, Biochemistry, Biophysics And Molecular Biology from University Of California, San Francisco.
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Protein biochemist and molecular biologist with research experience across a diverse range of fields including protein quality control and evolution, cellular homeostasis, neurodegeneration, cancer, and viral pathogenesis. I thrive working at the intersection of multiple disciplines and enjoy learning whatever new tool or expertise is necessary to answer the most pressing questions at hand. Additionally educated in astronomy and physics, I am fascinated with how biology emerged in the universe and believe mechanistic dissection in the context of evolutionary plasticity can help tackle some of the most complex problems in biology and disease.Breadth of technical experience including: molecular biology, protein expression and purification, enzymology, proteomics and phospho-proteomics mass spectrometry, cell culture (bacterial, yeast and mammalian), live-cell imaging, super-resolution microscopy, cryo-electron microscopy, data processing, and bioinformatics.Specific projects: ribosome-associated quality control (PhD thesis), evolution of kinase specificity, structure of viral protein-RNA condensates, transcriptional binding site evolution, proteomics of cancer therapy.--Howard CJ, Frost A (2021). Ribosome-associated quality control and CAT tailing. Critical Reviews in Biochemistry and Molecular Biology, https://doi.org/10.1080/10409238.2021.1938507.Carlson CR*, Asfaha JB*, Ghent CM*, Howard CJ, Hartooni N, Safari M, Frankel AD, Morgan DO (2020). Phosphoregulation of phase separation by the SARS-CoV-2 N Protein suggests a biophysical basis for its dual functions. Molecular Cell, https://doi.org/10.1016/j.molcel.2020.11.025.Sorrells TR, Johnson AN, Howard CJ, Britton CS, Fowler KR, Feigerle, JT, Weil PA, Johnson AD (2018). Intrinsic cooperativity potentiates parallel cis-regulatory evolution. eLife, 7:e37563.Rendon OZ*, Fredrickson EK*, Howard CJ*, Vranken JV, Fogarty S, Tolley ND, Kalia R, Osuna BA, Shen PS, Hill CP, Frost A, Rutter J (2018). Vms1p is a release factor for the Ribosome-associated Quality control Complex. Nature Communications, https://doi.org/10.1038/s41467-018-04564-3.Osuna BA, Howard CJ, Subheksha KC, Frost AS, Weinberg DE (2017). In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing. eLife, 6:e27949.Howard CJ*, Hanson-Smith V*, Kennedy KJ, Miller CJ, Lou HJ, Johnson AD, Turk BE, Holt LJ (2014). Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity. eLife, 3:e04126.* indicates equal contributions
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Emeryville, CA, US
- Project team lead for collaboration with Bristol Myers Squibb, applying Octant's expertise in Deep Mutational Scanning (DMS) to the characterization of immune signaling targets in disease and the development of DMS as a key tool for drug discovery and development.
Emeryville, CA, US
Individual contributor- Pushing the boundaries of Deep Mutational Scanning (DMS) capabilities toward novel drug discovery and development applications. Demonstrated utility of DMS in: de novo identification of therapeutic sites of action, functional characterization of Structure-Activity Relationships (SAR) to optimize protein-drug interactions, and.
San Francisco, California, US
- Biochemical and structural characterization of co-translational quality control by the Ribosomal Quality Control (RQC) complex to understand how RQC failure leads to proteotoxicity and neurodegeneration.- SARS-CoV-2 genome packaging and phase separation. Structural characterization of biomolecular condensates formed by N protein and RNA of SARS-CoV-2..
San Francisco, California, US
UCSF Bioregulatory mechanisms course
San Francisco, California, US
Studied the effects of cooperativity on the emergence and evolution of transcription factor binding sites.
San Francisco, California, US
Graduate student volunteer at the CLIAHUB emergency COVID-19 testing facility. Ran high-throughput qPCR assays with the BRAVO platform to assess presence of SARS-CoV-2 in collected patient samples. Prepared sample collection tubes. Received and accessioned viral swab samples.
København K, DK
Mass spectrometry on PDX tumors to decipher proteomic response to cancer therapies. Implemented CRISPR technology to induce cancerous fusion events in human cells to trace their progression toward cancerous states.
Berkeley, CA, US
Studied the evolutionary diversification of kinases to gain insight into their regulation and decode cancer-associated mutations. Performed the first ancestral reconstruction and purification of a large kinase group to probe the ancient biochemical determinants of kinase plasticity. Found phosphorylation kinetics and substrate specificity to drift.
Berkeley, CA, US
Bioinformatics analysis of poly-glutamine tract variation across fungal species. Work culminated in undergraduate honors thesis and study of low complexity sequences as modulators of reversible protein aggregation in response to cellular stress.
Berkeley, CA, US
Became certified to work with human subjects and use electroencephalography to determine brain patterns associated with visual recognition and decision-making.
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Conor Howard works for Octant.
Conor Howard is listed as DMS for Drug Discovery at Octant.
AeroLeads has found 1 work email signal at @octant.bio for Conor Howard at Octant.
Conor Howard is based in San Francisco Bay Area, United States, United States while working with Octant.
Conor Howard has worked for Octant, University Of California, San Francisco, Chan Zuckerberg Biohub, Københavns Universitet - University Of Copenhagen, and University Of California, Berkeley.
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Conor Howard holds Doctor Of Philosophy - Phd, Biochemistry, Biophysics And Molecular Biology from University Of California, San Francisco.
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