Corinne Thomas Email & Phone Number

Boston, Ma, Us

Leading protocol development for production and purification of antibody-DNA conjugates• Optimizing qPCR-based immunoassay conditions for small volume protein detection• Adapting protocols to high-throughput applications• Designing record forms and writing standard operating procedures• Development and implementation of quality control standards for reagent production• Researching and evaluating emerging techniques, reagents, and devices for adoption potential

Merck Exploratory Science Center• Developed and benchmarked sample preparation protocols for metabolomics analysis of clinical samples• Automated sample preparation methods to accommodate high throughput applications• Assessed data analysis workflows for high resolution untargeted mass spectrometry data• Performed R-based and vendor software analyses of LC/MS metabolomics data• Responsible for operation and upkeep of LC/MS QQQ and QTOF mass spectrometers• Regularly presented project goals, experimental data, and research conclusions at department meetings, monthly seminars, and to external collaborators

Boston, Ma, Us

Molecular Cardiology Research Institute (MCRI), Dr. Michael Chin LabProject: Develop a recombinant tafazzin protein to be used as an enzyme replacement therapeutic for the treatment of Barth syndrome• Built the foundation of mass spectrometry work in MCRI department, overseeing purchase and installation of LC/MS instrument, equipment,and consumables, establishing best practices for future lab use• Responsible for maintenance and upkeep of LC/MS QQQ mass spectrometer• Optimized protein expression and purification protocol for recombinant hydrophobic membrane protein• Established in vitro LC/MS based enzyme activity assay• Developed LC/MS based lipid profiling and quantification protocol for cultured cells and extracted murine cardiac mitochondria• Collaborated on cardiac reperfusion injury project both with labs in MCRI and in industry• Mentored graduate students and MIT Research Science Institute students in proper research and wet lab methods

Troy, Ny, Us

Center for Biotechnology and Interdisciplinary Studies (CBIS), Dr. Deepak Vashishth LabProject: Relate bone fracture potential to bone quality through the quantification of bone proteins and post-translational modifications (PTMs)• Characterized methods of extracting intact proteins from mineralized bone matrix tissue samples• Created an LC/MS assay to identify and quantify bone extracellular matrix proteins and protein post-translational modifications• Conducted mechanical testing on mouse and rat bone for fracture toughness and strength• Guest lectured for biomedical engineering lab course on data analysis and presentation• Conducted student study sessions and mentored undergraduates in laboratory techniques and experimental design

Toulouse, Midi-Pyrénées, Fr

Worked with a multinational group of students and investigators to evaluate the feasibility of novel applications for established protein kineticstechniques• Performed crystallization and adsorption experiments on bone mineral to characterize the interaction between bone protein and bone mineral

Groton, Connecticut, Us

Ithaca, Ny, Us

Department of Biomedical Engineering, Dr. David Putnam Lab• Project: Assess possible stabilizers preventing aggregation in antibody-based drugs• Designed, documented, and executed preliminary antibody aggregation experiments for future study

Ithaca, Ny, Us

Department of Chemical Engineering, Dr. Jeffrey Varner Lab• Project: Model the kinetics of physiochemical signaling cascades to match differential equation coefficients to experimental data• Developed and implemented Java based code to extract equation information from existing Systems Biology Markup Language files and write it to natural language

Doctor Of Philosophy (Ph.D.), Bioengineering And Biomedical Engineering

Master Of Engineering (M.Eng.), Bioengineering And Biomedical Engineering

Bachelor Of Engineering (B.E.), Bioengineering And Biomedical Engineering