Crystel Ogier Email & Phone Number

Paris, Fr

Paris, Île-De-France, France

Paris

• Planning and monitoring of activities for biomarker sample collection, management and logistics according to project priority and to ensure timely release of samples to analytical laboratories/CRO• Supporting clinical trial operations: review clinical trial protocols, informed consents, laboratory manuals, data transfer specifications. Define sample collection according to Biomarker plan. Support Central Laboratories for database and requisition form design• Ensuring clinical biomarker samples are collected according to CTP, ICF and Laboratory Manuals and in compliance with GCP and ICH Guidelines• Overseeing sample reconciliation and query solving in collaboration with Central Laboratories and Clinical Data Management to timely transfer sample information for clinical database lock.• Contributing to Precision Medicine: leading initiative with Central Laboratories to improve sample collection and processing at clinical sites and to optimize sample data annotations and tracking of sample information and quality for the use of samples during clinical trials and Companion Diagnostics development; defining guidelines and processes for clinical sample management and to ensure compliant storage and post-study use of samples• Managing sample relocation at end of clinical studies: monitoring external biobank, collaboration with clinical teams to retrieve and identify samples to relocate according to ICF restrictions, provide teams with budget estimation for relocation, management of query solving, relocation and destruction.• Supporting implementation of global BioSample LIMS for virtual sample management

Italy

Management of pre-clinical and clinical samples using LIMS systems (Watson LIMS, LabWare LIMS). Pre-analytical sample processing for pharmacodynamic (PD) biomarker analysis (DNA and RNA extraction from whole blood and tissue, plasma and serum aliquot)

Implementation and validation of a High-Throughput Automated platform for Functional Genomic.Application of genomic technologies for project support: Gene expression in separated immune cell subsets from healthy volunteers and patient samples, identification of disease and PD biomarker, understanding mode of action of compounds extended to autoimmune and inflammatory diseases.

Development of assays to measure protease expression and activity in primary human cell culture and in mouse models of diseases to support projects in autoimmune and inflammatory diseases. Exploration and identification of disease and PD Biomarkers

Implementation of rat model of global cerebral ischemia and in vitro models of excitotoxicity and neuroinflammation.Development of assays to measure MMP expression and activity in rodent CNS tissue and in primary neural cell cultures to characterize the involvement of MMP activity in neuronal death, neuroinflammation and cell migration.

Ph.D, Neuroscience

Ph.D done with a 3 year fellowship from Ligue Nationale contre le Cancer

Master, Cellular Biology And Physiology

First master prize from “Laboratoires Servier” and “Fondation Nationale de Gérontologie”