M.Sc Student, Yip Lab
CurrentInvestigating the molecular mechanism of HOPS-mediated autophagosome-lysosome fusion, using a combination of in vitro and in cellulo techniques.
Sep 2024 - Present
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Chloe S. E. House Email & Phone Number
Protein Biochemistry | Cell Biology | M.Sc Student at The University of British Columbia
at
The University of British Columbia
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Protein Biochemistry | Cell Biology | M.Sc Student at The University of British Columbia
Location
Vancouver, British Columbia, Canada
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Chloe S. E. House is listed as Protein Biochemistry | Cell Biology | M.Sc Student at The University of British Columbia at The University of British Columbia, based in Vancouver, British Columbia, Canada. AeroLeads shows a matched LinkedIn profile for Chloe S. E. House.
Chloe S. E. House previously worked as M.Sc Student, Yip Lab at The University Of British Columbia and Undergraduate Researcher, Yip Lab at The University Of British Columbia. Chloe S. E. House holds Master Of Science - Ms, Biochemistry And Molecular Biology from The University Of British Columbia.
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About Chloe S. E. House
Hello! I am Chloe, an M.Sc student currently working under Dr. Calvin Yip at the University of British Columbia. My project focuses on unravelling the molecular details of the autophagosome-lysosome fusion step of autophagy, using a combination of biochemical, structural, and cell-based techniques to achieve this.In the past, I worked in the labs of Drs. Patrick Keeling and Brett Finlay, studying single-celled protazoans and the bacterial Type 6 Secretion System, respectively. These experiences have cultivated my broad interest in diverse disciplines of life science research, especially in areas with practical applications in environmental and medical spheres. Furthermore, I am passionate about enhancing the ways that we communicate science, both within the research community and with the general public. I am actively seeking out opportunities that allow me to hone my skills in this area.Let's connect!
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5 roles
Chloe S. E. House work experience
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Undergraduate Researcher, Yip Lab
- Honours Thesis: Investigating the molecular mechanism of HOPS-ATG8 mediated autophagosome-lysosome fusion. - In vitro analysis of putative protein-protein interactions between the HOPS membrane tethering complex and autophagy-related ATG8 proteins, utilizing pulldowns with recombinant proteins.- In silico prediction of putative protein interaction domains and mapping of disease-associated mutations for downstream in vitro validation.- Written thesis selected as example work for future BIOC 448/449 students.
Jun 2023 - Aug 2024
Undergraduate Researcher, Keeling Lab
- Independently performed transmission electron microscopy on Apicomplexan protozoa, yielding high-quality images for morphological analysis of membrane structures in an evolutionary context.- Assembled genomes of the Ulvophyte algae Acetabularia, in order to shed light on its genome content. - Constructed single- and multi-gene trees to explore the phylogenetic position of Acetabularia and other newly-isolated Ulvophytes within the Ulvophyceae. - Presented findings at the Western Canada Protist Conference (2022).
May 2022 - May 2023
Undergraduate Research Assistant, Finlay Lab
- Independently designed, executed, and interpreted experiments including growth assays, competition assays, morphology experiments, and invasion assays with the goal of elucidating the function of specific toxin proteins associated with the E. coli Nissle Type 6 Secretion System. - Performed regular bioinformatics analyses of T6SS-related gene clusters, including searches for protein homology.
May 2021 - May 2022
Wet Lab Member, Ubc Igem
PILOT: Platformed Inteins, a Linked Orthogonal Toolkit. Involved in the design and execution of a cell-free protein synthesis optimization project, completed as part of the International Genetically Engineered Machine competition (2023 Jamboree Silver Medal Winner). Participated in training of 3 undergraduate students in techniques such as molecular cloning and gel electrophoresis.
Nov 2022 - Sep 2023
2 education records
Chloe S. E. House education
Master Of Science - Ms, Biochemistry And Molecular Biology
Bachelor Of Science (Honours), Biochemistry, 92%
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What company does Chloe S. E. House work for?
Chloe S. E. House works for The University of British Columbia.
What is Chloe S. E. House's role at The University of British Columbia?
Chloe S. E. House is listed as Protein Biochemistry | Cell Biology | M.Sc Student at The University of British Columbia at The University of British Columbia.
Where is Chloe S. E. House based?
Chloe S. E. House is based in Vancouver, British Columbia, Canada while working with The University of British Columbia.
What companies has Chloe S. E. House worked for?
Chloe S. E. House has worked for The University Of British Columbia and Ubc Igem.
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What schools did Chloe S. E. House attend?
Chloe S. E. House holds Master Of Science - Ms, Biochemistry And Molecular Biology from The University Of British Columbia.
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