X. Cyril Chen (He/Him)

X. Cyril Chen (He/Him) Email and Phone Number

Systems Engineer in Biosciences @ Factorial Biotechnologies
X. Cyril Chen (He/Him)'s Location
Houston, Texas, United States, United States
X. Cyril Chen (He/Him)'s Contact Details

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About X. Cyril Chen (He/Him)

Accomplished biomedical engineer with Research and Development expertise and achievements in microfluidics, optics and photo-physics. 15 years’ experience in design & engineering hardware automation module and complete systems for complex biological workflow and integration in both industrial and academic settings. Demonstrated success in dynamic start-up environment showcased by being an essential contributor for successful multi-million-dollar acquisition. Areas of expertise include: • Next Generation Sequencing (NGS) instrument design, build, maintenance and revisions from breadboard to pre-commercial prototype• Design & optimization of microfluidic systems for precise delivery of small volume of costly reagents• Full prototype system build including NGS sequencers, laser scanning multiphoton microscopes, ultrafast transient absorption spectrometers with femtosecond lasers• Fluorescence applications for DNA and protein detection and characterization • Multiple disciplines of light microscopy including epifluorescence, confocal, multiphoton, second-harmonic imaging, STED of super-resolution, and TIRF.• Cell culturing, fixation and immunostaining for cell focal adhesions and F-actin filaments.• Serial immunohistochemical (IHC) staining for multiple antigens on FFPE tissue slides• Solidworks for mechanical designs.• 3D printing for fast hardware prototyping and lab equipment improvements.• Motion (stages) and temperature (thermal cycling and isothermal) control.• LabView programming for instrument control, data acquisition and analysis.• Image analysis using ImageJ and LabView.• Spectroscopic skills for detection of gas and liquid molecules, including UV-VIS, FTIR, Laser spectrometers like ICOS and LIDAR, and platereader for fluorescence and absorption• Strong photonics background including light sources, photodetectors, optical filters, polarization components, and nonlinear optics.• Extensive experience with characterization and application of pulsed lasers.

X. Cyril Chen (He/Him)'s Current Company Details
Factorial Biotechnologies

Factorial Biotechnologies

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Systems Engineer in Biosciences
X. Cyril Chen (He/Him) Work Experience Details
  • Factorial Biotechnologies
    Principal Systems Engineer
    Factorial Biotechnologies Sep 2022 - Present
    San Carlos, Ca, Us
    Lead workflow automation of single cell genomics.
  • Berkeley Lights, Inc.
    Principal Product Engineer
    Berkeley Lights, Inc. Nov 2021 - Jul 2022
    Emeryville, Ca, Us
    Responsibilities at Berkeley Lights Inc. focused on improving product quality of the flagship Beacon optofluidic system, an automated on-chip cell culturing, imaging, manipulating machine with versatile single cell capabilities. Led investigation and resolution of system and assay for customer concerns that involved multiple departments/disciplines. Designed and performed tests for root cause and failure mode analysis. Provided guidance for design practices and controls to improve system reliability. Reviewed specifications for new product development.
  • Element Biosciences
    Staff Engineer
    Element Biosciences Oct 2020 - Nov 2021
    San Diego, California, Us
    Joined a system engineering team to develop the AVITITM sequencing platform based on the Element Avidity Sequencing chemistry. The sequencing platform is a high throughput imaging system with temperature and fluid controls for automated NGS sequencing workflows. The role focused on system integration and validation. Also led developing tools and methods to test sequencer performance.
  • Agilent Technologies
    Principal Biological Engineer
    Agilent Technologies May 2018 - May 2020
    Santa Clara, Ca, Us
    (Agilent Technologies acquired Lasergen, Inc. in 2018)Lead Engineer for development of sequencer instrument for the innovative NGS sequencing technology based on Lightning TerminatorTM chemistry. The R&D role involved working closely with molecular biologists, chemists and software developers and required a combination of engineering efforts in different disciplines and a working knowledge of biological and biochemical sciences• Improved performance metrics and turn-around-time by performing NGS experiments by modifying modules including motion, fluidics, temperature controllers.• Developed several off-sequencer systems and analyses as orthogonal tests to identify and implement performance improvement projects.• Collaborated with OEM engineering firms for transfer of development and manufacturing phase of the sequencers, by knowledge transfer, overseeing projects on several modules and reviewing verification testing protocols and results. • Interacted with several cross-functional and global teams for multiple ongoing projects identified by milestone-based OKRs (objective and key results) following several project management schemes including Agile, Scrum, Confluence, Jira and version control systems.• Lead and resolved several critical troubleshooting discussions including root cause analysis, repeatability, reproducibility, verification, validation, tracking and trending and performance-based issues.• Participated in advancing the program intellectual property value with several inventions.• Responsible for writing and presenting scientific summaries of several key advancements to diverse audience including engineering, biology, chemistry and management teams
  • Lasergen
    Staff Scientist
    Lasergen Oct 2011 - May 2018
    Houston, Texas, Us
    Lead Engineer for development of sequencer instrument for the innovative NGS sequencing technology based on Lightning TerminatorTM chemistry. The R&D role involved working closely with molecular biologists, chemists and software developers and required a combination of engineering efforts in different disciplines and a working knowledge of biological and biochemical sciences.• Designed and built prototype sequencers for early phase proof of principle research of LT chemistry and optimized hardware and protocols to advance the technology, as an essential contributor to the Lasergen acquisition by Agilent Technologies for $195 million in 2018. • Designed and executed custom, non-standard experimentation to investigate and resolve challenging issues including non-specific dye binding on flowcell surface, uneven reactivity, high failure rate of critical modules.• Implemented and supported several SOPs following Quality Standards using ISO 13485 principles.• Implemented preventative maintenance programs for sequencers and trained junior engineers in operation, maintenance and troubleshooting of modules• Evaluated single molecule capabilities of prototype systems by hardware redesign, proof of principle experiment design and result summary• Modified sequencer to enable automated serial immunohistochemical (IHC) staining and imaging for multiple antigens on FFPE tissue slides with photocleavable fluorescence probes.
  • University Of Wisconsin-Madison
    Postdoctoral Researcher
    University Of Wisconsin-Madison Sep 2010 - Oct 2011
    Madison, Wi, Us
    (Research group relocated to UW Madison in 2010)Worked in Dr. Paul Campagnola’s group to develop innovative nonlinear optical methods to study cancer cells and tissues for disease diagnosis and investigation of cancer metastasis mechanism.• Built a multiphoton microscope used for 3D fabrication of protein structures as models of extracellular matrix (ECM) enabling study of cell haptotaxis and cancer metastasis.• Developed cell immunostaining protocol to stain focal adhesions and cytoskeleton to investigate cell-ECM interaction.• Developed a circular dichroism (CD) method for second-harmonic generation (SHG) microscopy and successfully utilized it to detect abnormal collagen structure in diseased osteogenesis imperfecta (OI) connective tissue.
  • University Of Connecticut Health Center
    Postdoctoral Researcher
    University Of Connecticut Health Center Sep 2006 - Aug 2010
    Farmington, Connecticut, Us
    Worked in Dr. Paul Campagnola’s group to develop innovative nonlinear optical methods to study cancer cells and tissues for disease diagnosis and investigation of cancer metastasis mechanism. • Built a multiphoton microscope used for 3D fabrication of protein structures as models of extracellular matrix (ECM) enabling study of cell haptotaxis and cancer metastasis. • Developed cell immunostaining protocol to stain focal adhesions and cytoskeleton to investigate cell-ECM interaction. • Developed a circular dichroism (CD) method for second-harmonic generation (SHG) microscopy and successfully utilized it to detect abnormal collagen structure in diseased osteogenesis imperfecta (OI) connective tissue.

X. Cyril Chen (He/Him) Skills

Cancer Research Spectroscopy Research And Development Lasers Troubleshooting 3d Printing Cell Culture Engineering Immunostaining Microfluidics Labview Cancer System Integration Testing Nonlinear Optics Solidworks Design Research Motion Control Dna Sequencing Fluorescence Microscopy Automation

X. Cyril Chen (He/Him) Education Details

  • University Of Southern California
    University Of Southern California
    Physical Chemistry
  • University Of Science And Technology Of China
    University Of Science And Technology Of China
    Chemical Physics

Frequently Asked Questions about X. Cyril Chen (He/Him)

What company does X. Cyril Chen (He/Him) work for?

X. Cyril Chen (He/Him) works for Factorial Biotechnologies

What is X. Cyril Chen (He/Him)'s role at the current company?

X. Cyril Chen (He/Him)'s current role is Systems Engineer in Biosciences.

What is X. Cyril Chen (He/Him)'s email address?

X. Cyril Chen (He/Him)'s email address is cc****@****chc.edu

What schools did X. Cyril Chen (He/Him) attend?

X. Cyril Chen (He/Him) attended University Of Southern California, University Of Science And Technology Of China.

What skills is X. Cyril Chen (He/Him) known for?

X. Cyril Chen (He/Him) has skills like Cancer Research, Spectroscopy, Research And Development, Lasers, Troubleshooting, 3d Printing, Cell Culture, Engineering, Immunostaining, Microfluidics, Labview, Cancer.

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