Dr. Einstein has nearly 15 years experience participating in multiple interdisciplinary research teams focused on the development of continuum and multiscale models of organ systems.A recent focus area is the understanding and prediction of alveolar scale ventilator induced lung injury (VILI). This project combines the co-location of spatial mass spectrometry imaging (MSI) signals of inflammation biomarkers with imaging-based kinematic and multi scale modeling data. The research thrusts of this project are two fold. First, our work aims to measure and compute local ventilation from CT data from control and VILI subjects and correlate it with MSI data from the same subjects such that differences in the spectra between the two groups can be used to reveal spatial patterns of inflammation.Second, we are developing a multiscale computational model of the entire rodent respiratory, integrated with a novel and focused imaging study of regional parenchymal strain and alveolar dynamics. Parenchymal scale mechanics will be based on a novel implicit framework for lung parenchyma and will telescope to the alveolar scale, represented by stochastic populations of structural alveoli, articulated in terms of spatially arranged collagen, elastin and alveolar surfactant.For the last 10 years, Dr. Einstein has lead the Computational Core of PNNL's Virtual Lung project, focusing on the development the open-source technologies that are the foundation for PNNLs organ-to-cell multi scale program. In addition, he provides bioengineering expertise and leadership to assure that simulations are faithful to the underlying biophysics, that models are accurate and well documented, that their predictions accord with experimental data, and that modeling efforts are responsive to the scope of each project.

The Olympia Coalition for Ecosystems Preservation (OCEP) is an urban land trust in Olympia, WA, whose mission is to protect, preserve and restore Olympia’s key shoreline, nearshore and riparian areas, as well as their associated watersheds, in order to enhance the ecological health of Puget Sound and of our urban wildlife. This focus comes with unique challenges, as well as unique opportunities in our state’s capital city. We seek to integrate conservation and restoration of degraded areas within our urban community, in close proximity to our rapidly growing downtown, while providing access and education to the public and enhancing the well-documented mental and physical benefits of a public connection to nature.