I am responsible for daily operation of a San Diego based contract service and biomedical research product provider. BioPioneer is a leader in developing and marketing research tools for cell biology, molecular biology and stem cell research.

Worked at Dr. Mervyn Bibb group, I was responsible for developing vectors and streptomyces host for expression of recombinant natural products including different classes of antibiotics and also sucessfully increased a known anitbiotic production using conventional genetic and modern recombinant technology.

Conducted my postdoc. research at Dr. Jean Wang's lab at Department of Biological Science. Discovered the mechanisms by which the tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damagePublications:1. JianGen Gong, Antonio Cosanzo, Hong-Qiong Yang, Gerry Melino, William G. Kaelin, Jr., Massimo. Levrero, and Jean Y.J. Wang. 1999. The Tyrosine Kinase c-Abl Regulates p73 in Apoptotic Response to Cisplatin-Induced DNA Damage. Nature 399: 806-809.2. Levrero M, De Laurenzi V, Costanzo A, Gong J, Melino G, Wang JYJ. 1999. Structure, Function and regulation of p63 and p73. Cell Death Differ. 6:1146-1153. 3. Levrero M, De Laurenzi V, Costanzo A, Gong J, Wang JYJ, Melino G. 1999. The p53/p63/p73 family: biological redundancy or distinct functions. Journal of Cell Science.

Conducted my Ph.D study in Dr. Michael Brattain Lab.Publications:1. Wang J, Ko, TYC, Gong J and Brattain MG. 2004. Autocrine and exogeneous transforming growth factor beta control cell cycle inhibition through pathways with different sensitivity. Journal Biological Chemistry. 279(38): 40237-44.2.Gong J, Ammananchi S, Ko, TC and Brattain MG, 2003. Transforming growth factor beta1 increase the stability of p21/waf1/cip1 protein and inhibits CDK2 kinase activity in human colon cancer FET cells. Cancer Research, Jun.15, 63 (12): 3340-6.3. DanHui Wang, LuZhe Sun, Elizabeth Zborowska, James K.V.W, JianGen Gong, Janaki Verraraghavan and Michael G. Brattain. 1999. Control of type II Transforming Growth Factor-beta Receptor statement by Integrin Ligation. Journal of Biological Chemistry. 274, 12840-12847.4. Jenny Wang, JianGen Gong, Tien C. Ko, Xiao-Fan Wang, and Michael G. Brattain. 1999. Autocrine Negative TGF-beta1 Controls the Cell Cycle by Inhibition of Cyclin A/CDK2 complexes through a p21 Mediated Mechanism. Journal of Biological Chemistry. 5. JianGen Gong, Tien C. Ko, and Michael G. Brattain. 1998. Disruption of Fibronectin Binding to the Integrin alpha5 by alpha 5 Monoclonal Antibody Stimulates the DNA synthesis and Cyclin Dependent Kinase through Extracellular Signal-Regulated Kinases. Journal of Biological Chemistry. 273, 1662-1669.6. JianGen Gong, DanHui Wang, James K.V.Willson, Elizabeth Zborowska, LuZhe Sun, and Michael G. Brattain. 1997. Role of alpha5beta1 Integrin in Determining Malignant Properties in Colon Carcinoma Cells. Cell Growth & Differentiation 8: 83-90.7. DanHui Wang, Guo-hao Zhou, Thomas M. Birkenmeier, JianGen Gong, LuZhe Sun, and Michael G. Brattain. 1995. Autocrine Transforming Growth Factor beta1 Modulates the statement of Integrin alpha5beta1 in Human Colon Carcinoma FET Cells. Journal of Biological Chemistry 270, 14154-14159