Daniel Roche Email and Phone Number
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Accomplished Full-Stack Medical Research Scientist with 15 years of experience in biotechnology, specializing in Cancer Biology and immune-related diseases. Driven by a strong passion for working on fast-paced teams in startup environments and highly motivated to take on the most critical, time-sensitive, and challenging projects. Guided by a belief that each experiment chosen means another is left undone, I approach research with strategic focus and prioritize high-impact outcomes. Proven leader in managing cross-functional teams and achieving complex project goals through Agile methodologies. Expertise in immune cell therapeutics, gene editing (lentivirus and AAV), CAR T/B/NK cell production, high-dimensional flow cytometry, and advanced cell and tissue culture techniques. Deep foundation in drug discovery and cell therapy, supported by a Ph.D. in Molecular and Cellular Biology from UC Berkeley.
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Senior Business AnalystAdler Innovation Llc Nov 2024 - PresentWest Newton, Massachusetts, UsAs a Senior Business Analyst, I lead a project dedicated to leveraging AI and large language models to streamline competitive analysis processes for biotechnology companies. My role focuses on innovation and efficiency, driving impactful solutions for the industry.
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Associate DirectorWalking Fish Therapeutics, Inc. Mar 2023 - May 2024South San Francisco, California, UsDeveloped innovative strategies to condition B cells towards a plasma cell-like phenotype, enhancing memory B cell functions. Pioneered techniques for generating lentiviral vectors in both human and mouse B cells, enabling advanced genetic studies. Led a project to develop a syngeneic mouse model for evaluating B cell activity and targeting tumor environment. -
Associate DirectorChimera Bioengineering Mar 2022 - Jan 2023South San Francisco, California, UsLed a team of scientists focused on solving complex biological problems to develop generalizable solutions, with an emphasis on rapid and durable proof of concept. Through cross-team collaboration, we delivered transformative technologies and tools for Chimera Bioengineering using a high-risk, high-reward scientific approach. Additionally, coordinated with external CDMOs and institutions to sponsor and manufacture a Phase I trial, serving as the subject matter expert (SME) for CQA and characterization of autologous CAR-T products. Our ultimate goal was to accelerate innovation and expand treatment options for patients. -
Principal ScientistChimera Bioengineering Aug 2019 - Mar 2022South San Francisco, California, UsPrincipal Scientist in the Innovation Group which took on high risk and high reward projects• Performed optimization of therapeutic payloads for CAR T cells• Developed NK cell model of CAR-based regulated payload• Screened and identified numerous therapeutic compounds to control CAR T cells in clinic • Developed and validated use of CRISPR RNP in primary T cells for preclinical studies
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Staff Scientist - Clinical Genomics ResearchIllumina Jun 2018 - Aug 2019San Diego, Ca, Us• Built strong working relationships and alignment between scientists, genetic counselors, clinicians, UX, data scientist, software engineers, and marketing teams.• Designed and led team to develop "Patient Portal" to aggregate and stratify patient phenotypic (clinical) data. • Engaged with external partners to accelerate development, ensure user comprehension, and maximize customer satisfaction• Created a process to maximize efficiency and effectiveness in an ever-evolving environment• Collaborated with quality assurance and regulatory affairs to comply and produce documentation for FDA filing -
Manager, Biomedical InformaticsIllumina Nov 2014 - Jun 2018San Diego, Ca, Us• Developed workflows to harmonize and standardize genomic and phenotypic data into clinical reports• Facilitate product continuity and organizational alignment between different initiatives• Curated and process largest health initiative database (Framingham Heart Study)• Managed 4-6 Curation Scientists on diverse projects with shifting priorities and deadlines• Worked on a cross-functional team (Developers, Marketing, Quality Assurance and Biocomputing) to clinically transform Illumina software• Created internal databases to facilitate harvesting, sharing and reviewing of potential biomarkers
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Curation Scientist IiIllumina Oct 2013 - Nov 2014San Diego, Ca, Us• Harvested biomarkers for generating clinically actionable reports from diverse source material including PubMed, clinical trials, FDA-PMA, NCCN and ASCO guidelines, pharmaceutical product information and specialty databases • Subject matter expert (SME) for bioinformatics, engineering, sales and marketing teams• Created SOP and documentation for biomarker classification• Assisted in design of clinical user interface (UI) and biomarker summary reports• Provided review of other curators work
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Curation ScientistNextbio Dec 2011 - Dec 2013Santa Clara, Ca, Us• Identify biomarkers for generating clinically actionable reports• Write detailed reports for prognostic and predictive biomarkers• Created curation workflows to systematically track genomic information• Work on a multidisciplinary team to develop software solutions to genomic-based questions -
Associate Specialist IiUcsf 2011 - 2012San Francisco, California, Us• Isolated airway smooth muscle cells from wild type and Mfge8 knockout mice and investigated downstream signal transduction events• Analyzed BAL and peritoneal macrophages by FACS to identify the role of Mfge8 in apoptosis and collagen homeostasis• Created and purified various truncated Mfge8 proteins -
Postdoctoral FellowInstitut Curie 2006 - Jan 2011Paris, Fr• Determined the mechanism of action for select proteins using in vivo gain-of-function and silencing experiments• Cloned novel genes and created fusion proteins for purification and in vivo experiments• Expressed fluorescent proteins to determine sub-cellular localization during neural development• Validated novel antibodies for immunoprecipitation and coimmunoprecipitation studies -
Staff Research AssociateTularik 1997 - 2000Us• Developed secondary screen for E. coli helicase, topoisomerase I, and DNA ligase assays• Created deletion constructs to identify catalytic domain for DnaG protein• Collaborated with chemists for structure–activity relationship (SAR) studies -
Staff Research AssociateUcsf Medical Center 1996 - 1997San Francisco, Ca, Us• Proficiency in FDA-mandated good laboratory practice (GLP)• Investigated the pharmacokinetics of drugs in Phase II and III clinical trials• Quantitation of parent compounds and major metabolites in serum (LC/MS/MS)
Daniel Roche Skills
Daniel Roche Education Details
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University Of California, BerkeleyMolecular Biology -
Woods Hole Oceanographic InstitutionEmbryology Course
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California State University-SacramentoMolecular Biology
Frequently Asked Questions about Daniel Roche
What company does Daniel Roche work for?
Daniel Roche works for Adler Innovation Llc
What is Daniel Roche's role at the current company?
Daniel Roche's current role is Associate Director at Walking Fish Therapeutics.
What is Daniel Roche's email address?
Daniel Roche's email address is dr****@****ina.com
What is Daniel Roche's direct phone number?
Daniel Roche's direct phone number is +185825*****
What schools did Daniel Roche attend?
Daniel Roche attended University Of California, Berkeley, Woods Hole Oceanographic Institution, California State University-Sacramento.
What skills is Daniel Roche known for?
Daniel Roche has skills like Genomics, Molecular Biology, Biotechnology, Molecular Cloning, Genetics, Cell Biology, Confocal Microscopy, Oncology, Fluorescence Microscopy, Western Blotting, Drug Discovery, Biochemistry.
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