Daniel Takeuchi Email & Phone Number

Davis, CA, US

Kyoto, Japan

• Developed high yield novel production method (submitted to Japan Patent Office) to bio-transform crude herbal extract (astragaloside IV) to in-demand anti-aging compound, cycloastragenol.
• Discovered specific gut microbes that metabolize traditional herbal medicine (submitted to Japan Patent Office) to SDA compound with multiple physiological benefits in human health.
• Developed screening methods for anaerobic microbes to further understand metabolism of plant derived compounds in intestinal environment.
• Developed chemical analysis via HPLC / LCMSMS to monitor, elucidate target chemicals from traditional herbal medicines.
• Designed, developed protein purification scheme of target enzymes involved in the deglycosylation metabolism of astragaloside IV.

Pilot Point, TX

• Optimized, continually, fermentation process of multiple Paenibacillus strains from pipeline leads, illustrating positive results in field trials.
• Analyzed, presented research findings to CEO, Chief Science Officer, directors of science departments weekly.
• Developed methods of in-vitro antibiosis quantification for bacterial pipeline leads vs. fungal pathogens found in soybean plants (Pythium ultimum, Pythium irregulare, Rhizoctonia solani, Fusarium virguliforme.
• Developed method of testing root colonization of bacteria on soybean roots and stability of bacterial community during germination.
• Developed microbial seed treatment technologies for delivering beneficial microbes to agriculture seeds.
• Elucidated natural products chemistry of fermentation whole broth to ascertain active ingredients.

Davis, CA

• Increased Streptomyces microflavus production of miticidal metabolite 10X by developing fermentation process.
• Implemented procedures that reduced viscosity, to make process scalable, while simultaneously decreasing fermentation time; increased active ingredient (AI) production of Streptomyces microflavus.
• Developed methods for Bacillus subtilis and Bacillus pumilus spore stability testing, via prolonged heating times.
• Modified fermentation parameters to enhance colony forming unit (CFU) counts of Serenade (Bacillus subtilis), Sonata (Bacillus pumilus) for seed treatment applications on wheat, corn, soybeans.
• Led fermentation experimentation to increase titer of antifungal secondary metabolite production of Paenibacillus polymyxa.
• Independently designed, performed fermentation experiments using DOE.

Doctor Of Philosophy - Phd, Fermentation Physiology And Applied Microbiology

Masters, Fermentation Physiology And Applied Microbiology

Bs, Viticulture And Enology