Daniel Takeuchi Email & Phone Number

Davis, Ca, Us

Davis, Ca, Us

Kyoto, Japan

• Developed high yield novel production method (submitted to Japan Patent Office) to bio-transform crude herbal extract (astragaloside IV) to in-demand anti-aging compound, cycloastragenol.• Discovered specific gut microbes that metabolize traditional herbal medicine (submitted to Japan Patent Office) to SDA compound with multiple physiological benefits in human health. • Developed screening methods for anaerobic microbes to further understand metabolism of plant derived compounds in intestinal environment.• Developed chemical analysis via HPLC / LCMSMS to monitor, elucidate target chemicals from traditional herbal medicines.• Designed, developed protein purification scheme of target enzymes involved in the deglycosylation metabolism of astragaloside IV.

Pilot Point, Tx

Optimized, continually, fermentation process of multiple Paenibacillus strains from pipeline leads, illustrating positive results in field trials.• Analyzed, presented research findings to CEO, Chief Science Officer, directors of science departments weekly.• Developed methods of in-vitro antibiosis quantification for bacterial pipeline leads vs. fungal pathogens found in soybean plants (Pythium ultimum, Pythium irregulare, Rhizoctonia solani, Fusarium virguliforme, Phytophthora sojae, Macrophomina phaseolina).• Developed method of testing root colonization of bacteria on soybean roots and stability of bacterial community during germination.• Developed microbial seed treatment technologies for delivering beneficial microbes to agriculture seeds.• Elucidated natural products chemistry of fermentation whole broth to ascertain active ingredients.• Validated improvements in process development by analyzing fermentation data, in-vitro antibiosis, in-planta testing results.• Developed bacterial seed treatment stability testing.• Developed methods of in-vitro antibiosis quantification for pipeline leads vs. bacterial pathogens found in tomato and pepper plants (Pseudomonas syringae, Xanthomas campestris).

Davis, Ca

Increased Streptomyces microflavus production of miticidal metabolite 10X by developing fermentation process.• Implemented procedures that reduced viscosity, to make process scalable, while simultaneously decreasing fermentation time; increased active ingredient (AI) production of Streptomyces microflavus.• Developed methods for Bacillus subtilis and Bacillus pumilus spore stability testing, via prolonged heating times.• Modified fermentation parameters to enhance colony forming unit (CFU) counts of Serenade (Bacillus subtilis), Sonata (Bacillus pumilus) for seed treatment applications on wheat, corn, soybeans.• Led fermentation experimentation to increase titer of antifungal secondary metabolite production of Paenibacillus polymyxa.• Independently designed, performed fermentation experiments using DOE.

Doctor Of Philosophy - Phd, Fermentation Physiology And Applied Microbiology

Masters, Fermentation Physiology And Applied Microbiology

Bs, Viticulture And Enology