Study of bone marrow microenvironment in primary immunodeficiency (for example Wilskott Aldrich syndrome, beta-thalassemia, CGD and ADA-scid syndrome: isolation and characterization of biology and function of mesenchymal stromal cells (MSCs) and their interaction with hematopoietic stem cells CD34+ (HSCs)

I am working on mesenchymal stromal cells (MSC) at sperimental surgery laboratory of IRCCS Policlinico San Matteo in Pavia; in particular, I am focusing on isolation and expansion ex vivo of MSC from porcine bone marrow in view of their use in animal models of solid organ transplantation to facilitate engraftment The use of MSCs in large animals offers the possibility to better define their biological and functional properties and to identify possibly novel strategies of cellular therapy to… Show more I am working on mesenchymal stromal cells (MSC) at sperimental surgery laboratory of IRCCS Policlinico San Matteo in Pavia; in particular, I am focusing on isolation and expansion ex vivo of MSC from porcine bone marrow in view of their use in animal models of solid organ transplantation to facilitate engraftment The use of MSCs in large animals offers the possibility to better define their biological and functional properties and to identify possibly novel strategies of cellular therapy to ameliorate the graft acceptance in allogeneic transplantation. Show less