• Contribute to protocol review discussions to develop scientific rationale and procedural aspects of study design• Identify, track, prepare and organize documents in collaboration with Medical Monitor to provide to an independent adjudication committee for the evaluation of major adverse cardiovascular event (MACE) for NDA filing• Review of LTE clinical data within eCRF systems, data visualization software and TFLs for NDA filing• Meet with KOLs to discuss clinical trial strategies and approach • Conduct review of ongoing summary data including: safety and primary efficacy variables.• Perform extensive literature reviews and prepare summary documents for new clinical indications• Identification and analysis of subgroup of subjects from Phase 3 trials to initiate ideas for new clinical trials

In this position I work extensively within the cross-functional clinical development team to execute the clinical development plan. Responsibilities include:•Contributing to the design of clinical studies in close collaboration with the clinical development team•Performing regular medical review of individual subject data for assigned studies•Providing scientific support by interpreting safety and efficacy data, including collating,analyzing, reviewing, interpreting, and providing preliminary assessments and recommendations to support decision making•Contributing to database lock, statistical analysis plans, and preparation of clinical study reports and other clinical documents•Biomarker identification for clinical trials and/or indications (performing literaturereviews and analyzing pre-clinical and clinical data)•Review and written summarization of relevant literature•Contributing to drafting manuscripts and other publications and presentations•Developed a comprehensive drug and MOA training program as part of on-boarding for all full time and consultant clinical team members• Assumed responsibility for training staff and consultant MSLs in preparation for conference representation (ASCO, ASCO GI, ESMO)

- Assisted case managers in the evaluation of new invention from MGH and BWH- Working closely with IP group to assess patentability evaluation of new inventions - Assisted case managers in drafting and negotiating license agreements - Participated in meeting with faculty and key stakeholders

Laboratory of Dr Tayabba Hasan focuses on photochemistry-based approaches (photodynamic therapy, or PDT) to treat a wide number of diseases including cancer (ovarian, prostate, pancreas, oral, head and neck), infections and infectious diseases.Postdoctoral Research Fellow - Project 1: develops a rapid smart-phone platform that can detect antibiotic resistance by using a microfluidic system and a fluorescent probe.- Project 2: develops Three-Dimensional (3-D) models of cancer and cancer biology- Responsible for assay development and validation and also performing confocal microscopy- Design and develop methodology for use of lab-fabricated customized microfuidic pathogen capture device- Investigation of mechanisms involved in chemotherapy and photodynamic therapy respectively on growth and resistance

Laboratory of Dr Michael Hamblin, focuses on phototherapy for infections, cancer, and heart disease and low-level light therapy (LLLT) for wound healing, arthritis, TBI and hair regrowth.Postdoctoral Research Fellow - Project 1: Antimicrobial effect of Photodynamic Therapy in in vitro and in vivo studies testing the efficacy of new photosensitizers (project leader) Project done in collaboration with Molteni Therapeutics, Frontier Scientific, - Project 2: Efficacy of Hydrofera Blue to treat microbial wound infections (project leader) Project done in collaboration with Hollister Incorporated, Libertyville IL- Project 3: Antiseptic pulsed electric fields as alternative method to treat multidrug resistant bacteria in infected wounds. Project in collaboration with Shriner Burn hospital, Boston, MA (Investigator)- Project 4: Effect of a thioester dendritic hydrogel at 30 wt% to treat infected 2nd degree burn and hydrogel ability to prevent infection in 2nd degree burn murine models. Project in collaboration with Dr. Cynthia Ghobril, PhD, department of Biomedical Engineering, Boston University- Perform bioluminescence imaging in murine wounds model, BSL2 Experimentation, Bacteria Culturing,- Research lead to 5 papers and co-authors in 5 more papers. Wrote Bullock and ECOR grants, collaborate in writing NIH grants and animal protocols- Trained undergraduate and graduate students- Collaboration: Molteni Therapeutics (MT), Alexander Golberg, PhD, Shriner Burn hospital, Boston, MA. Hollister Incorporated, Libertyville IL, G. Felix Broelsch, M.D. Postdoctoral Research Fellow Division of Plastic and Reconstructive Surgery Massachusetts General Hospital. Dr. Cynthia Ghobril, PhD Postdoctoral Fellow department of Biomedical Engineering, Boston University, Frontier Scientific.- Mass General Postdoc Association (MGPA): attending meeting, helping in events organization

Immunopathology for Master Program in Biological Science

Department of Physiopathology, Experimental Medicine and Public Health, University of Siena, Llaboratory of Dr Concetta Gardi, focused on the role of oxidative stress in in vitro and in vivo model of lung and liver diseases. Evaluation of new drugs forReuhmatoid Artritis.Research- Proejct 1: Evaluation of Isoprostanes as markers and mediators in lung fibrosis.- Project 2: Evaluation of F2-isoprostanes as main mediators in pathogenesis of hepatic fibrosis.- Project 3: Chronic Obstructive Pulmonary Diesease (COPD). Murine alveolar macrophages response to cigarette smoke is strain dependent. - Collaborations: Professor Piero A. Martorana DVM, Frankfurt, Germany. Dr. Katarina Bauerova, Institute of Experimental- Pharmacology and Toxicology, Slovak Academy of Sciences, Bratislava, Slovak Republic. Dr. Hermann Tenor, NYCOMED- GmbH, Konstanz Germany. Associate Professor Giuseppe Valacchi, PhD Associate Professor Ferrara University and- Department of Nutrition, Kyung Hee University, Seoul, South Korea.- Biochemical and Immunoenzymatic assays; Enzymatic kinetics with synthetic and natural substrates; Assay and synthesis of molecules after incorporation of radioactive isotopes; Denaturing and non-denaturing polyacrylamide gel electrophoresis;- Zymography technique, Immunoblotting technique, RT-PCR, Collection and treatment of various organs and tissues from experimental animals, Animal model of lung and liver fibrosis, Culturing primary and line cells , Immunohistochemistry and immunofluorescence- Research lead to 3 peer reviewed publications and co-author in 4 more pubblications.- Responsible for managing laboratory reagents- Trained undergaduate and gratuate students.