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Daniel Mccoy is a Vice President - Preclinical Programs (Gene Therapy) at Avista Therapeutics. He possess expertise in molecular biology, molecular cloning, western blotting, neuroscience, assay development and 22 more skills. Colleagues describe him as "Dan worked as an intern in my lab before he started graduate school. His work was meticulous and his enthusiasm energizing. He approached his project with keen intelligence and obvious commitment. Dan has great people skills, and quickly became known as a colleague who could be relied upon to contribute where ever and when ever the opportunity arose.", "Dan was hired within our department as an intern and contractor, reporting to a colleague of mine. He assimilated very quickly and performed a variety of assays to support biomarker discovery in inflammation projects. He proved to be a very productive scientist whose data was reliable and trusted. He quickly became a valued member of the group during his tenure and worked well with everyone. I recommend Dan unconditionally.", and "I hired Daniel McCoy in 2008 to support our efforts in the development of ACAM529, a vaccine against genital herpes. Not only did Dan display a great deal of professionalism and competence in his work, but he also was a pleasure to work with at all times. Dan carried out successfully a number of virology and molecular biology experiments involving determination of viral titers by plaque assay and assessment of genetic stability of complementing eukaryotic cell lines by Southern blotting of DNA samples he isolated. He demonstrated a clear ability to carry out complex procedures independently as well as significant problem-solving skills. I would enthusiastically recommend Daniel McCoy to anyone interested in hiring him and wish him the best as he progresses in his career."
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Vice President - PreclinicalAvista Therapeutics Apr 2024 - Present -
Vice President - Preclinical ProgramsJaguar Gene Therapy Nov 2022 - Apr 2024Lake Forest, Il, Us• Preclinical lead overseeing gene therapy programs in the metabolic and neurological disease spaces.• Work closely with program SMEs, internal CMC, Regulatory, Clinical, and C-suite leadership to ensure safe and timely advancement of preclinical assets to IND.• Responsible for the design and execution of in vivo proof of concept and pivotal IND-enablingpharmacology/biodistribution/safety studies for AAV-based gene therapy products -
Director - Preclinical ProgramsJaguar Gene Therapy Aug 2022 - Nov 2022Lake Forest, Il, Us -
Associate Director - Preclinical ProgramsJaguar Gene Therapy Aug 2021 - Aug 2022Lake Forest, Il, Us -
Scientific AdvisorRarebase Aug 2021 - Feb 2022Palo Alto, California, Us -
Senior Scientist - Preclinical Gene TherapyBridgebio Aug 2019 - Aug 2021Palo Alto, California, Us• Preclinical program scientific lead tasked with supporting the development of gene therapy products from vector design through IND-enabling in vivo studies• AAV vector design/optimization, small scale viral production/process development, preclinical assay development, in vivo POC/ROA/DRF/Tox study design and biodistribution support• Primary point of contact responsible for early stage program vector design and optimization -
DirectorDaddy Daycare Jan 2019 - Aug 2019
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Principal Scientist - Platform DevelopmentStridebio, Inc Oct 2018 - Jan 2019Durham, North Carolina, Us• Lead the Platform Development team (3 direct report career scientists)• Responsible for the design and evolution of synthetic AAV capsids for various gene therapyindications (CNS, Liver, Eye – related)• Responsible for the development of novel molecular and cell-based assays and SOPs to meetcorporate goals and milestones• One of the first two lab-based hires of the company, in charge of setting up lab R&D operations• Part of the management team and intimately involved in the hiring and growth of the company (from 2 – over 25 full time employees) -
Senior Scientist - Platform DevelopmentStridebio, Inc Jan 2017 - Oct 2018Durham, North Carolina, Us -
Investigator - Translational ScienceGsk Aug 2015 - Nov 2016Brentford, Middlesex, Gb• Developing resident immune cell polarization assays in human ex vivo skin to model inflammatory skin disease states and support the development of relevant therapeutics• Developed a lipid gene based endpoint assay to evaluate candidate molecules targeting lipogenesis-related pathways• Contribute to both biomarker strategy, and transcriptomic disease signature study design/execution/characterization interfacing with external vendors and the GSK Computational Biology group• Contributed to the target engagement data package for the candidate selection (CS) milestone for a GSK asset• Designed proposals, wrote protocols, and managed external CRO contracts and academic collaborations -
Postdoctoral AssociateDuke University Aug 2014 - Aug 2015Durham, North Carolina, Us• Developed complex plate-based primary neuronal co-culture assays and assay endpoints for neurodegenerative disease research. In these cultures, primary cortical and striatal neurons are cultured together on a bed of primary glia. The individual isolation of the cell types prior to culturing allows for cell-type-specific responses to be measured simultaneously in a context that better reflects their interactions in vivo.• Screened novel therapeutics for toxicity and target engagement for pathways relevant to Huntington’s Disease -
Phd Molecular BiologyUniversity Of Southern California Aug 2008 - May 2014Los Angeles, Ca, Us“The expected and unexpected roles of TRPM8: Cold Pain and Metabolism”Project: 1) TRPM8 pore dilation can deliver therapeutics to cold-pain sensing neurons2) Enhanced insulin clearance in mice lacking functional TRPM8 channels• Utilized extensive molecular cloning, live cell imaging, and mouse in vivo techniques toindependently develop 6 unique transgenic mouse models for studying the roles of TransientReceptor Potential (TRP) ion channels in pain• Characterized a channel pore dilation model in vitro demonstrating that cationic therapeutics canbe delivered to cold-pain sensory neurons in a highly specific manner. Results particularly noveland impactful as it was previously thought to not be possible using this technique.• Discovered and published a novel insulin clearance phenotype for the thermosensory channelTRPM8 with therapeutic implications in regards to the treatment of diabetes and other metabolic disorders -
Associate Scientist IiiSanofi Pasteur Feb 2008 - Aug 2008Paris, France, Fr• Worked in the Bio-therapeutics department supporting the development of ACAM529, a preclinical vaccine against HSV-2 (genital herpes)• Supported both formulation and process development studies carrying out viral plaque assays and data quantification• Developed a chemiluminescent Southern blot protocol for identifying modified viral HSV-2 DNA in complementing cell lines• Carried out optimization studies for in house viral plaque assay SOP and presented findings to the ACAM529 team -
Summer Intern & Contract ScientistPfizer May 2006 - Aug 2007New York, New York, Us• Worked in the Biomarker Discovery department handling clinical samples in efforts to identify candidates for various inflammatory diseases (psoriasis, asthma etc.)• Performed ELISA analysis to support studies on inflammatory cytokine candidates and processed clinical samples for gene chip analysis (RNA extraction, quantification and stability studies using a Bioanalyzer) -
Summer InternBiogen May 2004 - Aug 2005Cambridge, Ma, Us• Worked as a summer intern in the Discovery Neurobiology department (2004+2005)• Cloned and expressed a neuroinflammatory receptor candidate in various soluble truncated forms• Worked with mammalian cell lines and the drosophila S3 cell line for expression of truncationvariants. Expression was analyzed by Western blot
Daniel Mccoy Skills
Daniel Mccoy Education Details
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University Of Southern CaliforniaMolecular Biology -
Wake Forest UniversityBiology
Frequently Asked Questions about Daniel Mccoy
What company does Daniel Mccoy work for?
Daniel Mccoy works for Avista Therapeutics
What is Daniel Mccoy's role at the current company?
Daniel Mccoy's current role is Vice President - Preclinical Programs (Gene Therapy).
What is Daniel Mccoy's email address?
Daniel Mccoy's email address is d.****@****wfu.edu
What is Daniel Mccoy's direct phone number?
Daniel Mccoy's direct phone number is +191948*****
What schools did Daniel Mccoy attend?
Daniel Mccoy attended University Of Southern California, Wake Forest University.
What skills is Daniel Mccoy known for?
Daniel Mccoy has skills like Molecular Biology, Molecular Cloning, Western Blotting, Neuroscience, Assay Development, Cellular Biology, Elisa, Rna Isolation, Pcr, Microarray, Immunohistochemistry, Mammalian Cell Culture.
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