Daniel Doheny, Phd Email & Phone Number

Chapel Hill, Nc, Us

Durham, North Carolina, United States

As a Scientist I at BioAgilytix, I serve as the lead scientist on multiple projects involving method development, transfer, qualification, and validation of pharmacokinetic, anti-drug antibody, neutralizing antibody, and enzyme-linked immunosorbent spot (ELISpot) assays through contributions to assay design, execution, and drafting of client-centric deliverables. I routinely prepare assay plans, protocols, and reports; manage study documentation, present data to clients, and meet project deadlines with quality results.• 98.5% plate pass rate across development, qualification, validation, and sample analysis assays performed under GLP/GCLP guidelines.• Support the professional development of new employees as an instructor of the Lab Calculations New Employee Onboarding seminar. • Key technical proficiencies include: Laboratory Inventory Management Software (LIMS), ZenQMS, Gen5, MesoScale Discovery (MSD), Vi-Cell, Synergy Neo2

Greensboro/Winston-Salem, North Carolina Area

I earned my PhD in Cancer Biology under the mentorship of Dr. Hui-Wen Lo at the Wake Forest Graduate School of Arts & Sciences. My dissertation research involved identifying and characterizing small molecule inhibitors of the novel oncogenic protein tGLI1 to prevent and treat breast cancer brain metastases and recurrent gliomas. • Evaluated the efficacy and mode of action of 4 novel compounds (2 with commercial viability) that inhibit a novel actionable target, upregulated in brain metastases and gliomas, leading to 7 training awards totaling over $150,000.• Implemented standardized protocols to image and analyze immunohistochemistry staining to profile tumor samples increasing throughput by 75% and reducing experimental error by at least 25%.• Developed professional relationships with key scientists and clinical oncologists resulting in 7 peer-reviewed publications on topics including breast cancer and cancer therapeutics.• Presented scientific data at 6 internal seminars and 3 international conferences, including the American Association for Cancer Research Annual Meeting.• Mentored 7 trainees including junior graduate students, rotating medical students, and undergraduate students.• Managed laboratory budget and ordering systems, overseeing total yearly budget exceeding $500K.

Raleigh-Durham, North Carolina Area

As a Scientist at ScitoVation, I worked as part of a multidisciplinary team to develop and optimize high-throughput cell-based multiplex assays to redefine the paradigm of toxicity testing by reducing animal use and enhancing human relevance through the implementation of in vitro-based risk assessment strategies using human-derived cells and cell preparations using high-content imaging fluorescence microscopy. My efforts were primarily dedicated to 2 projects: 1) Development of an in vitro assay based on our uterine endocrine disruption model to better predict uterine responses to estrogenic compounds, and 2) Development of in vitro assays to model adipocyte hyperplasia resulting from chemical-induced peroxisome proliferator-activated receptor gamma (PPARG) and glucocorticoid receptor activity. • Collaborated to develop a multiplex cell-based assay to measure tissue-specific estrogen responses leading to 1 publication and a podia presentation at the 5th Annual meeting of the American Society for Cellular and Computational Toxicology.• Optimized an ELISA to assess xenobiotic-induced adipokine secretion featured in 2 publications.• Mentored and trained 2 technicians on sterile cell culture and assay execution.• Prepared quarterly reports to provide updates on completion of key deliverables.• Managed chemical and cell line inventory.

Raleigh-Durham, North Carolina Area

After ICSS was acquired and rebranded into ScitoVation, a wholly owned subsidiary of SciMetrika, I was hired as a Scientist and expanded on my previous work at The Hamner.• Evaluated several assay technologies to measure estrogen-induced uterine cell growth culminating in 1 publication.• Streamlined chemical inventory and safety documentation management which reduced waste by 50%.

Raleigh-Durham, North Carolina Area

I spent one year as an intern at the Institute for Chemical Safety Sciences (ICSS) of The Hamner Institutes for Health Sciences, a not-for-profit brain trust that advanced new human-systems biology approaches for chemical safety assessment through the development of in vitro assays that incorporate human cell lines to characterize major toxicity pathways. During this time, I became proficient in sterile cell/tissue culture and generation of stable cell lines using lentiviral transduction before moving on to assist in the optimization of several single-plex and multiplex in vitro assays.• Presented 2 scientific posters describing the acquired data at The Hamner Technology Showcase Series.

Chapel Hill, Nc

• Organized employees to prepare gym facilities for use by student teams and organizations.• Served as an information resource for employees and patrons on gym policies.• Supervised groups of 6+ employees during my shift.• Worked 12 hours per week while attending school full time.

Chapel Hill, Nc

• Distributed sports equipment to gym members.• Served as a source of information on gym policies and planned events for gym patrons.• Provided superb customer service.• Worked at least 6 hours per week while attending school full time.

Doctor Of Philosophy - Phd, Cancer Biology

Activities and Societies: American Association for Cancer Research (AACR), Society for Neuro-Oncology (SNO), Society for the Advancement.

Master Of Science - Ms, Biomedical Sciences

Activities and Societies: American Association for Cancer Research (AACR), Society for Advancement of Chicanos/Hispanics and Native.

Bachelor Of Science - Bs, Biochemistry

Activities and Societies: Global Medical Brigades, Carolina Pre-Medical Association, La ISLA SchoolAdditional degrees awarded: Bachelor.

Education record

Activities and Societies: Varsity Soccer Team, HOSA - Future Health Professionals, Spanish Honors Society, Key Club