Danielle Ruser Email & Phone Number

Philadelphia, Pa, Us

Philadelphia, Pennsylvania, United States

Philadelphia, Pennsylvania, United States

As a Translational Development Intern at Century Therapeutics, I delve into the world of cellular therapies in Philadelphia, PA. My core responsibilities span the cultivation and maintenance of diverse mammalian cell lines, ensuring their optimal growth and viability.I actively contribute to the development and validation of critical immunogenicity assays, including CDC, ADCC, and ADCP.I independently conduct sophisticated flow cytometry analyses, utilizing 10+ color flow cytometry panels (CytoFlex) to assess killing efficacy for ADCC and ADCP. Moreover, I analyze pro-inflammatory cell supernatant cytokines using the MSD platform, offering valuable insights into inflammatory responses.Handling Leukopaks from healthy donors is another integral part of my role, essential for preparing specimens for downstream in vitro assays. I also engage in in-depth analysis of specific killing data in various assay formats, contributing to a nuanced understanding of the interaction between immunogenic patient serum and product cells.In addition to my laboratory duties, I showcase effective communication skills through regular contributions to lab meetings and presentations at journal clubs. I also take the initiative to streamline our electronic lab notebook (ELN) and sample management systems on Benchling, optimizing clinical biospecimen inventory logging through customized schemas.Furthermore, I actively participate in scientific writing, assisting in the creation and editing of Standard Operating Procedures (SOPs) to ensure clarity and compliance in our assay protocols.My journey as a Translational Development Intern at Century Therapeutics is characterized by a relentless pursuit of scientific excellence, collaboration, and ongoing learning. I am eager to leverage my experiences and expertise to contribute meaningfully to the advancement of innovative cellular therapies in the biotechnology landscape.

Philadelphia, Pennsylvania, United States

As I embark on my final term as an undergraduate student at Drexel University, I am passionately committed to supporting and guiding underclassmen as they commence their academic journey. Currently serving as a Teaching Assistant under the mentorship of Dr. Monica Togna and Dr. Kevin Smith, I play a pivotal role in ensuring that students in their courses have the necessary resources and support to thrive.In my capacity as a Teaching Assistant, I actively engage with students, providing guidance, clarification, and encouragement as they navigate challenging concepts and coursework. I am dedicated to fostering an inclusive and collaborative learning environment where every student feels empowered to excel and explore their full potential.My role involves facilitating discussions, assisting with assignments, and providing valuable feedback to enhance the learning experience. I am committed to promoting academic excellence and helping students develop the skills and confidence they need to succeed both inside and outside the classroom.As I transition from being a student to a teaching assistant, I bring a unique perspective and a genuine interest in their sucess. I am eager to continue making a positive impact on the academic journey of my peers and contributing to the vibrant learning community at Drexel University.

Upper Providence, Pennsylvania, United States

I completed my second co-op as a Scientific Student Worker part of the Drug Metabolism and Pharmacokinetics In Vitro group at GlaxoSmithKline's Research and Development Hub in Upper Providence, PA. During this six month period, I directed various studies on a weekly basis to contribute to the knowledge of the behavior of compounds in the drug development process. My training as a co-op began with learning how to operate the DMPK group's TECAN, using it to complete high throughput microsomal clearance assays on a weekly basis. During the course of this assay, I was responsible for loading the deck of the TECAN with the appropriate labware and solutions, preparing necessary solutions, and appropriate handling of biohazards. I was responsible for working up the data I received from the bioanalysis group following their analysis, along with reviewing the data and controls for each assay. Shortly after perfecting the process for the clearance assay, I learned the protocol for matrix stability assays in rat and human blood. While running this manual assay, I was responsible for proper handling of compounds and blood, timely collection of samples over the course of the incubation period of the assay, and proper disposal of biohazards. Once I felt confident in my understanding of the procedure, I was given the opportunity to assist in validating this assay on the TECAN. I independently conducted this assay on the TECAN seven times over the course of four months, reviewing the data alongside my supervisor each time and participating in discussions to improve the assay scripting on the TECAN. My resilience through the repeated testing and dedication to improving this assay enabled the In Vitro group to make great strides toward fully automating their matrix stability assay. In the final two months of my co-op I was also tasked with assisting in the validation of the microsomal clearance assay on a second, newly purchased TECAN so that the assay may run on both robots.

As a full time intern through the Co-op program at Drexel, I analyzed the contents of wastewater for southwest Philadelphia using chemistry techniques. I was responsible for the analysis of 30+ samples per day, using techniques like pipetting and massing samples to gather data. On a daily basis, I followed standard operating procedures to perform titrations, use centrifuges, mass samples, mix solutions, and maintain a sample log for all of my work. Each day, I reported valuable data to the engineers at the wastewater control plant that was essential in understanding the functionality of the plant responsible for 300 million gallons of wastewater per day.

Doylestown, Pennsylvania, United States

Quakertown, Pennsylvania, United States

Bachelor Of Science - Bs, Biology, General

Education record