Danielle Sliter, Ph.D. Email and Phone Number
Danielle Sliter, Ph.D. work email
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Danielle Sliter, Ph.D. personal email
I'm “all-in” kind of person, motivated by a deep drive to make a positive impact in the world. I dive in, fully to whatever is in front of me, from science and drug development, to my family and community building, from teaching and mentoring to outdoor adventuring. I am passionate, creative and determined in everything I do. My greatest professional joy comes from connecting concepts and leading the science, people and functions so that a strategy can be fully formed and its potential realized commercially to have the maximum impact to patients. I love to find efficiencies, and identify creative solutions to optimize drug development from discovery to the clinic and the company's portfolio strategy. This is what I am best at: seeing the Big Picture and bridging the gap in between the science (R&D) and the business case (Commercial), from either side, to allow for aligned portfolio and research strategies. - I use my deep scientific expertise to develop strategies to address significant unmet need, and collaborate cross-functionally to deliver innovative and impactful solutions for patients. - I translate strategic vision into tactical action from early research to product development with a focus on commercial impact. - I articulate vision, as a whole or in it's component parts, to any audience at any level. - I use my knowledge, experience and the power of communication to influence decisions, teach and inspire, and steer strategic direction. With these skills and my experience, I could fit into and excel in many roles, across several functions, where strategic thinking, scientific understanding, business acumen and collaborative leadership is required.I thrive by proactively improving my knowledge & skills so that I can take-on new challenges, whether personally: supporting my husband's brewery venture (Third Hill Brewing), or professionally: enabling scientific advances and for enriching my career prospects. I am excited to explore opportunities that allow for the intersection of science with business, to bring forward the most innovate and impactful solutions for patients.
Latus Bio
View- Website:
- latusbio.com
- Employees:
- 33
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Business Development And Portfolio StrategyLatus BioRockville, Md, Us
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Associate Director Business DevelopmentLatus Bio Jul 2024 - PresentBusiness Development, Investor Relations and Portfolio Strategy; functioning at the intersection of science and business to advance company objectives, support financing and long-term company growth through strategic partnerships and portfolio planning.
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Ad, Global Project And Program ManagementAstrazeneca Mar 2024 - Jul 2024Gaithersburg, Maryland, United StatesProgram management of high-priority discovery stage antibody-drug conjugate projects to accelerate to critical developmental milestones. -
Associate Director, Portfolio Strategy And New Product PlanningRegenxbio Inc. Jul 2022 - Nov 2023Rockville, Maryland, United StatesI identified, gained support for and reenergized research efforts around a compelling scientific approach to address an overlooked opportunity with high potential commercial impact - Translated primary and secondary research into business insights to inform portfolio product planning and early research project development - Developed cross-functional comparative framework for evaluation of early research programs for prioritized development - Aligned Research, Clinical and Commercial functions around strategy for development of high priority ophthalmology and neuromuscular programs using science-based benchmarks - Steered portfolio strategy and product development through communication of science and business insights to executive leadership -
Senior ScientistRegenxbio Inc. Sep 2019 - Jul 2022Rockville, MdI designed and lead early research projects to establish proof-of-biology for novel gene therapies focused on neurodegeneration, movement disorders and neuroinflammation - Built a cross-functional team to execute proof-of concept studies and delivery candidate gene therapies to critical Go / No-Go decisions - Evaluated novel gene therapy concepts for prioritized development - Identified targets for and develop strategies to address unmet need in neurological diseases
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Postdoctoral FellowThe National Institutes Of Health Jul 2011 - Jun 2019Bethesda, MdI lead several research projects exploring the cell biology of Parkin- and PINK1- mediated mitochondrial quality control, and its implications in the development of Parkinson's disease. I forged a new path in the Youle Lab and explored a novel hypothesis that damaged mitochondria that can not be cleared due to mutations in Parkin and PINK1 could trigger innate immune activation. This hypothesis led to identifying a role for the kinase TBK1 in clearing damaged mitochondria via interaction with the autophagy adapter OPTN, which was published as a co-first authorship in Nature in 2015. Most importantly, TBK1 is linked to innate immune activation in response to cytosolic DNA via activation of STING. Following up on this, my work then identified a causal role for activation of STING in the neurodegeneration of substantia nigral neurons in a mouse model of Parkinson's disease where damaged mitochondrial can not be cleared due to loss of Parkin. This work, published in Nature in 2018, has invigorated research on the role of neuroinflammatory processes in the development of neurodegenerative disease.Sliter, D.A., et. al. Nature. 2018 Lazarou, M., Sliter, D.A., Kane, L.A. et. al. Nature. 2015 -
Postdoctoral ResearcherSuny Upstate Medical University Jan 2011 - Jul 2011Syracuse, NyI continued my thesis work to assess the function of candidate E3 ligases in IP3 receptor ubiquitination, and pharmacological agents in the processing of IP3 receptors for degradation. After leaving this lab, I continued in a collaborative effort using TALEN and CRISPR technology to delete candidate E3 ligases, resulting in greater understanding of the mechanism of IP3 receptor down-regulation. -
Graduate StudentSuny Upstate Medical University Sep 2004 - Dec 2010Syracuse, NyFor my thesis work, I studied the ubiquitination and degradation of inositol 1,4,5 -trisphosphate (IP3) receptors. IP3 receptors are regulated Ca2+ channels that aid in sequestering Ca2+ in the endoplasmic reticulum (ER). The stimulated release of Ca2+ from ER stores is important for many cellular homeostatic processes and failure to regulate this process can lead to disease. My work focused on the signal that targets IP3 receptors for degradation following activation, ubiquitin. Realizing that traditional methods of studying ubiquitination would be cumbersome for IP3 receptor research, I developed a collaboration with the Gygi lab to use (then) cutting edge mass spectrometric techniques, resulting in the publication of two first-author papers and culminating in a Ph. D. with distinction.
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Medical TechnicianSuny Upstate Medical University Jul 2002 - Aug 2004performed routine blood chemistry, urinalysis, and microbiology testing on patient samples
Danielle Sliter, Ph.D. Skills
Danielle Sliter, Ph.D. Education Details
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Suny Upstate Medical University-With Distinction -
Biology -
The Clarkson SchoolBiology
Frequently Asked Questions about Danielle Sliter, Ph.D.
What company does Danielle Sliter, Ph.D. work for?
Danielle Sliter, Ph.D. works for Latus Bio
What is Danielle Sliter, Ph.D.'s role at the current company?
Danielle Sliter, Ph.D.'s current role is Business Development and Portfolio Strategy.
What is Danielle Sliter, Ph.D.'s email address?
Danielle Sliter, Ph.D.'s email address is da****@****nih.gov
What schools did Danielle Sliter, Ph.D. attend?
Danielle Sliter, Ph.D. attended Suny Upstate Medical University, Syracuse University, The Clarkson School.
What are some of Danielle Sliter, Ph.D.'s interests?
Danielle Sliter, Ph.D. has interest in Other Cultures, Scuba, Reading, Science (Of Course), Running.
What skills is Danielle Sliter, Ph.D. known for?
Danielle Sliter, Ph.D. has skills like Molecular Biology, Cell Biology, Science, Cell Culture, Western Blotting, Tissue Culture, Microbiology, Confocal Microscopy, Molecular Cloning, Chemistry, Cell, Fluorescence Microscopy.
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