Darshil P. Email & Phone Number

United States

Chicago, Illinois, United States

Philadelphia, Pennsylvania, United States

Initiate and plan new pipeline discovery projects, providing feasibility studies and timelines for project progressionIdentify and evaluate new CAR alternative technologies to support pipeline studies.Lead the Molecular Biology department to oversee plasmid, protein, and vector core activities. Design and oversee the execution of experiments involving diverse in vivo and in vitro assays.Establish a protein core to support the preclinical needs by producing and purifying tagged recombinant proteins, antibodies, and other protein-based molecules. Lead the protein engineering scientist to efficiently optimize the pre-clinical CAAR design for enhanced efficacy and target engagement. Work internally and with outside vendors to develop mouse models and interact with CROs regarding IND-enabling studies. Lead the preclinical assay development efforts to validate and execute Luminex and ELISA-based assays.Manage workflow of the vector core, including production, validation, and titer assays.

Philadelphia, Pennsylvania, United States

Philadelphia

Build a protein chemistry lab to support preclinical assessment of cell therapy concept that will be directed at treating auto immune diseasesWork internally and with outside vendors to develop and execute screening assays to assess cell – tissue interactions at the molecular levelSet-up, validate and execute protein purification methods and analysis assays. develop, and execute assays to assess the cell surface proteins interactions with various tissues and immunoglobulins Develop assays to evaluate protein – protein interactions of cell-based products with human tissues and blood components

Lead and plan experimental validation activities to develop OneThree’s pipeline of novel oncology targets and assets.Create and execute research strategies for drug development, ranging from target selection to IND enabling studies, to provide clear go-no/go decisions and timelinesDesign assays and experimental protocols (in-vitro to in-vivo) to measure target-disease relevance, and target-compound engagement, and better understand underlying biological mechanisms of action.Work as the liaison with external CROs for all wet lab validation, specifically focusing on the preclinical mechanism of action/pathway studies, toxicology, compound screening, assay development, and in vivo model development.Work with OneThree research team to incorporate AI platform predictions into preclinical validation strategies.Work with the executive team and key advisors to create strategies around target selection and prioritization, and communicate findings to both technical and non-technical stakeholders in the company

Newark, Delaware

Led the development and/or qualification of assay products for clinical chemistry and immune-based in vitro assay systemsLed or participated in design control regulated activities such as risk management, design verification, design change, process characterization and validationRepresented Assay Development in cross-functional meetings and discussions Guided the work of biochemists, establishing plans, protocols, and reports along with troubleshooting technical problems

Ithaca, New York Area

Ithaca, New York Area

Hong Kong

Greater Los Angeles Area

Greater Los Angeles Area

Riverside, Ca

Doctor Of Philosophy (Phd), Cancer Biology

Bachelor Of Science (B.S.), Molecular, Cell And Developmental Biology