Dave Stewart

Dave Stewart Email and Phone Number

Research Scientist @ Rapafusyn Pharmaceuticals
Dave Stewart's Location
Sykesville, Maryland, United States, United States
Dave Stewart's Contact Details

Dave Stewart personal email

n/a
About Dave Stewart

Preclinical Research Scientist with over 20 years of experiences in the biopharmaceutical industry encompassing a breadth of therapeutic targets and technology platforms with particular expertise in oncology and virology. Highly adaptable scientist who has contributed substantially at multiple stages of preclinical pharmacology, including target validation, biochemical and cell-based assay development, candidate drug screening and characterization, mechanism of action, and pharmacokinetics, for projects targeting receptor signaling, angiogenesis, ion channels, programmed cell death, immuno-oncology, and oncolytic viruses.

Dave Stewart's Current Company Details
Rapafusyn Pharmaceuticals

Rapafusyn Pharmaceuticals

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Research Scientist
Dave Stewart Work Experience Details
  • Rapafusyn Pharmaceuticals
    Research Scientist
    Rapafusyn Pharmaceuticals Jun 2022 - Present
    Baltimore, Maryland, Us
  • Glycomimetics
    Research Scientist I
    Glycomimetics Sep 2015 - Present
    Rockville, Md, Us
    • Produced, qualified, and distributed a flow cytometry reagent, Phycoerythrin conjugated E selectin protein (GMI-2010), for detection of E selectin ligands expressed on blast cells in bone marrow aspirates from AML patients enrolled in clinical trials. In addition to a Material Safety Data Sheet, QA-reviewed batch records were completed during each production and qualification of the custom reagent. Lot-specific data sheets were prepared and included with the packed reagent for shipment.• Planned, executed, and analyzed preclinical research studies that screen candidate glycomimetic molecules by ELISA for competitive binding-inhibition, ability to overcome cell adhesion mediated - drug resistance (CAM-DR) in HUVEC co-culture, and assess potential as an immunotherapeutic for MM using NK cell cytotoxicity assay. Also designed and developed biomarker ELISAs for detection of E selectin ligands in AML serum, and performed in silico gene expression analysis of potential genetic biomarkers associated with E selectin ligand expression and AML. • Prepared and presented project updates in weekly group meetings, monthly research meetings, and meetings with consultants, subject matter experts, and CROs. Author on four posters presented at AACR or ASH and a patent application• Coordinated and executed a range of laboratory duties, including 1) maintenance and calibration of laboratory equipment to support a documented, QA-reviewed process, 2) procurement and repair of laboratory equipment, 3) procurement of consumable supplies and reagents, and 4) maintenance of frozen cell bank and reagent antibodies inventories
  • Medimmune
    Scientist
    Medimmune 2004 - Aug 2015
    Gaithersburg, Maryland, Us
    Scientist I, Oncology Research 2007 – 2015• Planned, coordinated, executed, and analyzed preclinical studies addressing target validation, assay development, candidate screening, mechanism of action, pharmacokinetics, and preclinical pharmacology of therapeutic targets in receptor signaling, angiogenesis, and immunotherapy.• Responsible for project leadership on receptor signaling projects, including written and oral presentations of data and strategic plans to Research Management, as well as coordination of a collaboration with a KOL.• Prepared and presented posters at external and internal scientific meetings.Associate Scientist II, Preclinical Oncology 2004 – 2006• Planned, executed, and analyzed in vivo pharmacology of candidate antibodies, assessing efficacy and mechanism of action in subcutaneous and orthotopic xenograft models, as well as extending target validation to additional indications and characterizing new candidate antibodies.
  • Saic
    Research Associate
    Saic 2003 - 2004
    Reston, Va, Us
    Research Scientist, Biodefense Division• Planned and executed experiments to support development of technology providing rapid detection and identification of microbial bio-threat agents.
  • Genetic Therapy, Inc.
    Scientist
    Genetic Therapy, Inc. 1994 - 2003
    Senior Scientist I, Oncolytic Vector Program 2000 - 2003 • Planned, coordinated, executed, and analyzed preclinical studies evaluating oncolytic vectors in subcutaneous and metastatic tumor xenograft models. Endpoints included efficacy, toxicity, dose regimen, pharmacokinetics, mechanism of action, biomarker validation, combination therapy, and biodistribution.• Supervised scientists who assisted with technical aspects of preclinical studies, biomarker validation and development of novel preclinical models.• Authored internal study reports supporting promotion of oncolytic viruses from Research to Development and presented oral abstracts at three scientific conferences.Scientist IV, Oncology Program 1998 - 2000 • Co-developed a novel and rapid method for constructing adenoviral vectors with mutagenized adenoviral fiber genes.Research Associate III, Immunology Program 1994 - 1998 • Created genetically targeted adenoviral vectors with tumor selective promoters and constructed retroviral vectors designed to enhance the bystander effect of HSV-thymidine kinase using molecular biology techniques.

Dave Stewart Skills

Assay Development Biotechnology Molecular Biology Elisa Immunology Monoclonal Antibodies Antibodies Immunoassays Drug Discovery Cell Culture Cell Biology Life Sciences Cell In Vitro Biochemistry Western Blotting Lifesciences

Dave Stewart Education Details

  • University Of Maryland Baltimore County
    University Of Maryland Baltimore County
    Biology

Frequently Asked Questions about Dave Stewart

What company does Dave Stewart work for?

Dave Stewart works for Rapafusyn Pharmaceuticals

What is Dave Stewart's role at the current company?

Dave Stewart's current role is Research Scientist.

What is Dave Stewart's email address?

Dave Stewart's email address is ds****@****ics.com

What is Dave Stewart's direct phone number?

Dave Stewart's direct phone number is +141023*****

What schools did Dave Stewart attend?

Dave Stewart attended University Of Maryland Baltimore County.

What skills is Dave Stewart known for?

Dave Stewart has skills like Assay Development, Biotechnology, Molecular Biology, Elisa, Immunology, Monoclonal Antibodies, Antibodies, Immunoassays, Drug Discovery, Cell Culture, Cell Biology, Life Sciences.

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