Dave Edgren Email & Phone Number

Palo Alto, CA, US

• Designed and developed osmotic dilators for remodeling biological tissues
• Identified and formulated semipermeable elastomeric membrane systems and osmotic engines to dilate biological ducts
• Designed and fabricated prototype devices for use in dilating nasal ostia
• Demonstrated successful functionality in animal models and in humans
• Devices based on the prototype design are now commercially available in the EU

Hayward, California, US

• Performed root cause analysis on batches of a commercial tiny time pill product
• Identified sources of variability in dissolution performance attributed to the spray coated, rate controlling membrane
• Sources of variability included raw material of membrane composition, coating solvent composition, and processing conditions
• Improved reproducibility of the membrane permeability and dissolution performance

• Developed direct compression formulations of SR tablets for oral administration
• Formulated and characterized powder blends (flow, compression curves, propensity for punch sticking) and tablets (tensile strength, content uniformity, dissolution patterns)
• Monitored manufacture at CMO of Phase 2b supplies through 40 kg scale
• Inventor on patent application for these dosage forms and processes to manufacture them

• o Generated concepts to potentially enhance drug delivery and evaluated the feasibility of these concepts. The concepts included the areas of
• increasing extent of drug absorption in the gastrointestinal tract
• designing biodegradable implants and depots for delivery of drug to the posterior of the eye
• developing hydrogels for use as electrodes in electrotransport systems to deliver drugs across skin and ocular tissueso Presented concepts to upper management

• o Developed a wide variety of coatings for use on oral dosage forms including
• acetone-based, aqueous-based, and ethanol-based membrane formulations
• membranes with permeability values that respond to changes in osmotic pressure to produce different delivery patterns
• high flux and low flux membranes for fast and slow drug delivery
• stable and cosmetically elegant color coating films for tablets with surfaces that commercial color coating companies were unable to successfully spray coat with their off-the-shelf formulationso Developed erodible.
• hydrogel matrix systems with printed insoluble bands to control drug delivery rate patterns (RingCap)

• Developed osmotic systems with internal buffering systems to control drug solubility and delivery
• Developed rate control membranes for osmotic oral dosage forms with permeability values that respond to changes in pH