David Hurtado Email & Phone Number

• Directed and managed preclinical research models conducted at third-party contract research organizations (CROs).
• Managed multiple parallel in vivo studies at various stages of development from contracting, protocol generation, execution, and reporting.
• Reviewed, interpreted, and presented data to internal departments and externally to company partners.

• Managed CRO metabolomics research studies from study design to final report deliverables.
• Analyzed and interpreted large metabolomic datasets to identify biological insights for pre-clinical research in various diseases, and communicated findings through written reports and verbal presentations.
• Collaborated with company-wide teams to ensure timeliness of projects, advance internal R&D, and aid in sales and marketing efforts.

• Study Director of in vivo preclinical research studies evaluating small molecules, biologics and viral therapeutics.
• Oversee, coordinate and manage all phases of research studies with internal departments and external pharmaceutical, biotech, and academic clients.
• Provide scientific oversight in study design and execution.
• Manage research project goals, timelines and milestones.
• Review, interpret, and integrate data into written reports for both internal use and external client deliverables.
• Provide technical and scientific guidance to research staff and develop protocols and standard operating procedures.

Somerville, MA

• Project manager of contract research projects for pharmaceutical, biotech, and university clients.
• Responsible for the development, execution and management of all contract research projects.
• Supervised laboratory personnel and maintained laboratory operations.

Bedford, MA

• Project leader of In Vivo Pharmacology
• Conducted preclinical pharmacological in vivo studies to evaluate pharmacokinetics, pharmacodynamics, and efficacy of small molecules across multiple programs in oncology, inflammation, immuno-oncology, and.

Cambridge, MA

• Project leader of In Vivo Pharmacology - Managed and developed in vivo models. - Identified project goals, designed appropriate studies and timelines, and allocated resources to achieve study objectives.
• Managed companywide internal pharmacokinetic, and pharmacodynamic projects.
• Achieved preclinical milestone in collaboration with Biogen Idec by designing and executing key in vivo target validation experiments.

Cambridge, MA

• Developed in vivo models of neurodegeneration to be used for efficacy testing.
• Designed an in vivo biomarker strategy for Proteostasis’ Cystic Fibrosis Program.
• Managed vendors and CROs in support of internal pharmacology group.
• Devised and authored new study protocols, and obtained IACUC approval.
• Trained research technicians, and coordinated their time and abilities to the successful completion of project goals.

Philadelphia, PA

• Researched and developed novel in vivo mouse models of neurodegenerative disorders.
• Developed two novel conditional knock-out mouse models to study the molecular pathogenesis of neurodegenerative disorders.
• Utilized immunohistochemical and biochemical techniques to explore the progression of tau and Aß pathology.
• Generated a novel recombinant shRNA virus to knock-down and investigate the role of glycogen synthase kinase in an in vivo model of Alzheimer’s Disease.
• Employed behavioral, biochemical and histological techniques to ascertain both neuropathological and cognitive changes.
• Developed cell-based models of APP metabolism in both primary and immortal cell lines.

Bethesda, MD

• Researched cellular trafficking of Glutamate Receptor, KA2.
• Identified mechanisms involved in heteromeric channel formation, ER egress and retention.

New York, New York

• Researched and developed sensory kinases using green fluorescent protein (GFP).
• Identified fusogenic Golgi SNARE complexes using SNARE-dependent lipid mixing assays.
• Developed and conducted research in eliciting retrograde Golgi to Endoplasmic Reticulum trafficking.
• Presented findings and collaborated with peers in furtherance of project goals.

West Point, Pennsylvania

• Developed therapeutic antibodies against infectious bacterial organisms.
• Defined unique bacterial surface proteins for the discovery of new vaccines by developing novel approaches to screening, expressing, and purifying surface proteins.
• Participated in additional projects including design and development of novel vector constructs for new methods in rapid screening and expression of genomic libraries.
• Collaborated on programs in advancement of developing therapeutic antibodies.

Collegeville, Pennsylvania

• Investigated protein expression of hematopoietic cell lines undergoing apoptosis.
• Investigated novel gene expression in stimulated hematopoietic cell lines during erythrocyte development.

Phd, Neuroscience

First Year Studies Towards Juris Doctorate

Bachelor Of Science (B.S.), Molecular And Cell Biology