Dave Solis Email & Phone Number

San Diego, CA, US

• Established and currently leads the screening and SAR laboratory for small molecule drug discovery.
• Oversees the design, development, validation and implementation of biochemical and cell-based in vitro pharmacology readouts for small molecule profiling, as well as laboratory automation and data informatics processes.
• As core member of project teams, provides guidance on establishing screening cascades and compound profiling workflows for multiple programs.
• Identifies, selects and manages CRO partners for HTS campaigns and orthogonal follow up efforts. Performs data analysis and QC applying established internal business rules, and subsequent transfer to in-house research.
• Partners with research informatics software developers in establishing assay workflows for high throughput data analysis, capture and processing for data-driven analytics.

San Diego, CA, US

• Identifies, evaluates and implements new technologies and methods to improve quality and efficiency of HTS campaigns and SAR profiling.
• Develops and executes non-routine and exploratory in vitro assays to support characterization of small molecules and targeted protein degraders such as mechanistic studies and kinetic HiBiT degradation assays.
• Mentors and provides guidance for the skill and career development of direct reports and trainees.
• Executed focused library monotherapy and combinatorial screens as well as supporting SAR and orthogonal assays.

New York, New York, US

• Develops, optimizes and miniaturizes biochemical and cellular assays amenable to automated high-throughput screening in 384-well formats. Acts as a resource individual to ~15 colleagues and assists in automating and.
• Conducts mid-to-high throughput screening (Kinase Glo, ADP Glo, FP, SPA, TR-FRET, efflux and reporter assays) of chemical libraries, specialty compound collections and subset files aimed at identifying small molecule.
• Executes and analyzes kinetic and mechanistic studies to characterize enzyme targets, as well as selectivity screening of potential lead compounds.
• Develops and implements orthogonal assays for further characterization of confirmed hits.
• Performs potency and Ki assays to drive in vitro SAR, as well as assays for SIR (counter-screens, redox, label free aggregation), that help identify, triage and de-risk pan-assay interference compounds (PAINS).
• Facilitates method transfer, oversees and serves as point person for uHTS screens conducted by contracted third parties.

New York, New York, US

Switzerland 🇨🇭, CH

• Developed, adapted and implemented automated high-throughput biochemical screens aimed at identifying small molecule therapeutics for both oncology and autoimmune indications
• Determined potency, binding, kinetic mode of inhibition, solubility and selectivity of compounds in hit characterization, validation and subsequent stages of drug discovery process
• Performed high volume data analyses and subsequent reporting and publication using Genedata and Activity Base
• Conducted routine biochemical potency assays to support and drive project SAR studies
• Developed a TR-FRET assay and successfully implemented and screened Roche full library (~1.2M compounds) followed by hit confirmation and validation by IC50 determination and label-free binding studies
• Developed an AlphaLISA assay for identifying small molecule p53 tumor suppressor stabilizers/activators

Morris Plains, New Jersey, US

• Provided technical support for the Preclinical department in the in vitro functional characterization and elucidation of the mechanisms of action of humanized monoclonal antibodies and antibody conjugates, which.
• Proficiently maintained cell cultures of various solid tumor lines (breast, pancreatic, prostate, lung, epidermal, colon, gastric, ovarian, thyroid, cervical) and B cell malignancies, as well as large-scale hybridoma.
• Performed routine mycoplasma testing using commercially available kits
• Actively participated in assay development, method qualification, validation and method transfer in support of Investigational New Drug (IND) submissions
• Maintained proper laboratory data documentation and subsequently evaluated and performed statistical analyses using Excel and GraphPad Prism
• Presented data to upper management as well as to peers during regular meetings

New York, NY, US

• Carried out quantitative analysis of biological molecules in clinical and non-clinical serum samples generated from animal and human studies by radioimmunoassay (RIA) using in-house or commercially available 3H and.
• Performed Chloramine-T radioiodinations
• Accomplished in vitro ADME studies evaluating the role of liver microsomal and cytosolic cytochrome P450 enzymes in the metabolic fate of synthetic progestins
• Prepared buffers, serum controls, and standard solutions
• Performed minor animal surgical procedures (subdermal implantation, castration, isolation of rat pituitary gland, and blood collection)
• Performed basic molecular techniques such as RNA isolation, RT-PCR and gel electrophoresis

Ms, Biology

Bs, Biology

Education record

Molecular Bioscience