David Butler Email and Phone Number
Navigating the realm of oligonucleotide drug discovery and development is akin to traversing a complex labyrinth. The industry faces familiar pain points associated with the unpredictable journey of developing a novel class of therapeutics. This field, brimming with potential, is equally laden with challenges such as the high attrition rates in drug development pipelines, manufacturing, the struggle for funding against uncertain outcomes, and intense competition in bringing novel therapies to market.These hurdles are not just technical – they represent a profound challenge in the quest for new treatments. Organizations and researchers often find themselves grappling with wasted resources and lost time, overshadowing the primary goal of delivering timely, life-saving treatments to those in need.Having led teams in oligonucleotide drug discovery, I've witnessed these challenges firsthand and understand the frustration they bring. This experience has instilled in me a dedication to finding solutions that address these issues directly, aiming to streamline the journey from discovery to delivery.The key lies in embracing innovation and technologies, fostering collaboration, and applying strategic foresight. By adopting proven strategies that allow us to navigate the landscape more efficiently, the path to successful drug discovery can be significantly smoothed.Offering expertise that transcends traditional methods, I am committed to partnering with organizations to transform the challenges of oligonucleotide drug discovery and development into successful, impactful therapies. With a focus on efficiency and collaboration, there is a promise of progress and satisfaction in your drug discovery endeavors.If your organization is poised to redefine its approach to oligonucleotide drug discovery and development, let’s start a conversation. Together, we can tackle the challenges and unlock the immense potential of this exciting field, turning obstacles into opportunities to realize groundbreaking therapeutic breakthroughs.
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Chief Technology OfficerHongene Biotech CorporationBoston, Ma, Us -
Chief Technology OfficerHongene Biotech Corporation Jan 2023 - PresentBoston, Massachusetts, United StatesHongene is a global specialist in nucleic acid raw material supply and CDMO services, committed to providing high-quality, high-value products with best-in-class lead times.Dedicated to the universal accessibility of nucleic therapies, we apply our world-renowned expertise and specialized capabilities to ensure your project is delivered on time, in full and on budget.As a trusted partner with decades of world class experience in the field, we provide end-to-end guidance along your journey to patients with a vertically integrated supply chain that supports you from small-scale synthesis to GMP manufacturing — all underpinned by consistently high purity, market-leading capacity and a commitment to innovation. We can grow together and realize the high potential of nucleic acids to bring life changing therapies to patients. -
Member Board Of DirectorsAkte Therapeutics Nov 2023 - PresentPreclinical stage gene therapy company using exosome delivered RNA therapies for tuneable control of gene expression to treat rare disease. -
Entrepreneur In ResidenceYale Ventures Feb 2023 - PresentBoston, Massachusetts, United Stateshttps://ventures.yale.edu/about/entrepreneurs-in-residence -
Vice President, Head Of ChemistryKorro Bio, Inc. Apr 2021 - Nov 2022Cambridge, Massachusetts, United States• Leadership team member, establishing business strategy, issue resolution• Built a multi-tiered chemistry organization that including oligonucleotide synthesis, medicinal andcomputational chemistry, compound management, oligonucleotide analytics, outsourcing,and CMC• Early Program Team lead for Alpha-1 Antitrypsin. Established a screening funnel paradigm forLead Discovery• Founder and leader of the Oligonucleotide Design Team, matrixed across Discovery todrive the advancement of oligonucleotide chemistry and design processes• Established a global network of small molecule and oligonucleotide suppliers to support Discovery and Development -
Vice President, Head Of Therapeutic DevelopmentAlltrna Aug 2020 - Apr 2021Cambridge, Massachusetts, United States• Member of leadership team during progression from ‘NewCo’ to ‘GrowthCo’. Developed earlybusiness strategy including mission, vision and goals• Inventor of early technology advancements -
Vice President, Head Of Medicinal ChemistryWave Life Sciences Feb 2019 - Jul 2020Cambridge, Massachusetts, United States• Advanced Wave’s regulatory control strategy for API stereochemistry• Interfaced with health agencies regarding CMC through type B, C, and Scientific Advice meetings• Oversaw a global network of CMO/CROs• Developed strategic partnerships to build innovative, scalable, and cost‐effective manufacturingsolutions• Participated in cross‐functional teams driving discovery pipeline into development -
Senior DirectorWave Life Sciences Mar 2014 - Feb 2019• Oversaw design and construction of lab supporting chemistry discovery, and annual in‐housemanufacture of up to 100 kg of stereodefined phosphoramidites• Led scale‐up, supply chain continuity and regulatory control strategy for API starting materialsincluding CPG support and a portfolio of 40 stereodefined phosphoramidites• Created a forecast system for stereodefined RSM and API manufacture• Established strategic partnerships with CMO/CROs, conducted technical audits• 2016 CREST award winner (awarded annually to one outstanding employee at Wave)
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Principal ScientistOntorii Inc Mar 2011 - Mar 2014Ontorii and Chiralgen joined together to form Wave Life Sciences• Joint inventor of foundational Wave compositions IP• Synthesis of chiral amidite building blocks, oligonucleotides and oligonucleotide prodrugs• Joint inventor of the SOSIC method for mixed backbone stereodefined phosphorothioateoligonucleotides• Designed first experiments exploring the impact of phosphorothioate stereochemistry onoligonucleotide pharmacology in vivo (Nature Biotechnology, 2017)
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Principal ScientistAlnylam Pharmaceuticals Apr 2007 - Mar 2011• Synthesis of building blocks – Lipids, phosphoramidites, ligands, linkers, solid supports, peptides,formulations• Project lead or core team member on multiple siRNA discovery teams• Supervised laboratory expansion, lab safety and chemical inventory management• Co‐leader of academic R&D collaboration with MPI‐CBG, Dresden• Managed activities of 6 chemists at an Indian CRO to support internal platform development -
Senior ScientistOrganix Inc. Dec 2001 - Apr 2007Woburn, Massachusetts, United StatesContract Research and Custom Synthesis.• Multi‐step synthesis of more than 400 unique final compounds at mg to kg scale for customersacross pharmaceutical and chemical industries• Joint inventor of a new class of monoamine re‐uptake inhibitors (pyrovalerones) for potentialcocaine addiction therapy and treatment of Parkinson’s disease. NIH supported.• All work met pre‐established deadlines and purity specifications with zero failure• Solved an extremely difficult chemistry problem for a pharmaceutical partner, enabling synthesis of 60triazolopyridine antibacterials, named joint inventor on patent• Synthesis and isolation of 120 compounds within 6 months for biotech partner, explored astreatment for parasitic animal disease -
PostdocQueen Mary, University Of London May 2001 - Nov 2001London, England, United KingdomPostdoctoral Fellowship supported by the Engineering and Physical Sciences Research Council (EPSRC).• Investigated molecular gears as components for nanoscale systems• Developed asymmetric organometallic catalysts as chiral DMAP analogs -
PostdocCardiff University Jan 2000 - Apr 2001Relocated to Queen Mary, University of London -
PostdocUniversity Of Ottawa Dec 1997 - Dec 1999Ottawa, Ontario, CanadaPostdoctoral Fellowship supported by the Natural Sciences and Engineering Research Council (NSERC) and the Environmental Science and Technology Alliance of Canada (ESTAC).• Achieved phosgene‐free, ‘green’ route to industrially important isocyanates• Explored palladium catalyzed ring‐opening of aziridines and azetidines with heterocumulenes togive biologically relevant heterocycles
David Butler Education Details
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Chemistry -
Chemistry
Frequently Asked Questions about David Butler
What company does David Butler work for?
David Butler works for Hongene Biotech Corporation
What is David Butler's role at the current company?
David Butler's current role is Chief Technology Officer.
What schools did David Butler attend?
David Butler attended University Of St Andrews, University Of St Andrews.
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David Butler
Lexington, Ky2voltaicsolar.com, alltech.com4 +185949XXXXX
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David Butler
Salem, Nh3gmail.com, aol.com, gmail.com4 +171854XXXXX
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