David Butler

David Butler Email and Phone Number

Chief Technology Officer @ Hongene Biotech Corporation
Boston, MA, US
David Butler's Location
Greater Boston, United States
About David Butler

Navigating the realm of oligonucleotide drug discovery and development is akin to traversing a complex labyrinth. The industry faces familiar pain points associated with the unpredictable journey of developing a novel class of therapeutics. This field, brimming with potential, is equally laden with challenges such as the high attrition rates in drug development pipelines, manufacturing, the struggle for funding against uncertain outcomes, and intense competition in bringing novel therapies to market.These hurdles are not just technical – they represent a profound challenge in the quest for new treatments. Organizations and researchers often find themselves grappling with wasted resources and lost time, overshadowing the primary goal of delivering timely, life-saving treatments to those in need.Having led teams in oligonucleotide drug discovery, I've witnessed these challenges firsthand and understand the frustration they bring. This experience has instilled in me a dedication to finding solutions that address these issues directly, aiming to streamline the journey from discovery to delivery.The key lies in embracing innovation and technologies, fostering collaboration, and applying strategic foresight. By adopting proven strategies that allow us to navigate the landscape more efficiently, the path to successful drug discovery can be significantly smoothed.Offering expertise that transcends traditional methods, I am committed to partnering with organizations to transform the challenges of oligonucleotide drug discovery and development into successful, impactful therapies. With a focus on efficiency and collaboration, there is a promise of progress and satisfaction in your drug discovery endeavors.If your organization is poised to redefine its approach to oligonucleotide drug discovery and development, let’s start a conversation. Together, we can tackle the challenges and unlock the immense potential of this exciting field, turning obstacles into opportunities to realize groundbreaking therapeutic breakthroughs.

David Butler's Current Company Details
Hongene Biotech Corporation

Hongene Biotech Corporation

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Chief Technology Officer
Boston, MA, US
David Butler Work Experience Details
  • Hongene Biotech Corporation
    Chief Technology Officer
    Hongene Biotech Corporation
    Boston, Ma, Us
  • Hongene Biotech Corporation
    Chief Technology Officer
    Hongene Biotech Corporation Jan 2023 - Present
    Boston, Massachusetts, United States
    Hongene is a global specialist in nucleic acid raw material supply and CDMO services, committed to providing high-quality, high-value products with best-in-class lead times.Dedicated to the universal accessibility of nucleic therapies, we apply our world-renowned expertise and specialized capabilities to ensure your project is delivered on time, in full and on budget.As a trusted partner with decades of world class experience in the field, we provide end-to-end guidance along your journey to patients with a vertically integrated supply chain that supports you from small-scale synthesis to GMP manufacturing — all underpinned by consistently high purity, market-leading capacity and a commitment to innovation. We can grow together and realize the high potential of nucleic acids to bring life changing therapies to patients.
  • Akte Therapeutics
    Member Board Of Directors
    Akte Therapeutics Nov 2023 - Present
    Preclinical stage gene therapy company using exosome delivered RNA therapies for tuneable control of gene expression to treat rare disease.
  • Yale Ventures
    Entrepreneur In Residence
    Yale Ventures Feb 2023 - Present
    Boston, Massachusetts, United States
    https://ventures.yale.edu/about/entrepreneurs-in-residence
  • Korro Bio, Inc.
    Vice President, Head Of Chemistry
    Korro Bio, Inc. Apr 2021 - Nov 2022
    Cambridge, Massachusetts, United States
    • Leadership team member, establishing business strategy, issue resolution• Built a multi-tiered chemistry organization that including oligonucleotide synthesis, medicinal andcomputational chemistry, compound management, oligonucleotide analytics, outsourcing,and CMC• Early Program Team lead for Alpha-1 Antitrypsin. Established a screening funnel paradigm forLead Discovery• Founder and leader of the Oligonucleotide Design Team, matrixed across Discovery todrive the advancement of oligonucleotide chemistry and design processes• Established a global network of small molecule and oligonucleotide suppliers to support Discovery and Development
  • Alltrna
    Vice President, Head Of Therapeutic Development
    Alltrna Aug 2020 - Apr 2021
    Cambridge, Massachusetts, United States
    • Member of leadership team during progression from ‘NewCo’ to ‘GrowthCo’. Developed earlybusiness strategy including mission, vision and goals• Inventor of early technology advancements
  • Wave Life Sciences
    Vice President, Head Of Medicinal Chemistry
    Wave Life Sciences Feb 2019 - Jul 2020
    Cambridge, Massachusetts, United States
    • Advanced Wave’s regulatory control strategy for API stereochemistry• Interfaced with health agencies regarding CMC through type B, C, and Scientific Advice meetings• Oversaw a global network of CMO/CROs• Developed strategic partnerships to build innovative, scalable, and cost‐effective manufacturingsolutions• Participated in cross‐functional teams driving discovery pipeline into development
  • Wave Life Sciences
    Senior Director
    Wave Life Sciences Mar 2014 - Feb 2019
    • Oversaw design and construction of lab supporting chemistry discovery, and annual in‐housemanufacture of up to 100 kg of stereodefined phosphoramidites• Led scale‐up, supply chain continuity and regulatory control strategy for API starting materialsincluding CPG support and a portfolio of 40 stereodefined phosphoramidites• Created a forecast system for stereodefined RSM and API manufacture• Established strategic partnerships with CMO/CROs, conducted technical audits• 2016 CREST award winner (awarded annually to one outstanding employee at Wave)
  • Ontorii Inc
    Principal Scientist
    Ontorii Inc Mar 2011 - Mar 2014
    Ontorii and Chiralgen joined together to form Wave Life Sciences• Joint inventor of foundational Wave compositions IP• Synthesis of chiral amidite building blocks, oligonucleotides and oligonucleotide prodrugs• Joint inventor of the SOSIC method for mixed backbone stereodefined phosphorothioateoligonucleotides• Designed first experiments exploring the impact of phosphorothioate stereochemistry onoligonucleotide pharmacology in vivo (Nature Biotechnology, 2017)
  • Alnylam Pharmaceuticals
    Principal Scientist
    Alnylam Pharmaceuticals Apr 2007 - Mar 2011
    • Synthesis of building blocks – Lipids, phosphoramidites, ligands, linkers, solid supports, peptides,formulations• Project lead or core team member on multiple siRNA discovery teams• Supervised laboratory expansion, lab safety and chemical inventory management• Co‐leader of academic R&D collaboration with MPI‐CBG, Dresden• Managed activities of 6 chemists at an Indian CRO to support internal platform development
  • Organix Inc.
    Senior Scientist
    Organix Inc. Dec 2001 - Apr 2007
    Woburn, Massachusetts, United States
    Contract Research and Custom Synthesis.• Multi‐step synthesis of more than 400 unique final compounds at mg to kg scale for customersacross pharmaceutical and chemical industries• Joint inventor of a new class of monoamine re‐uptake inhibitors (pyrovalerones) for potentialcocaine addiction therapy and treatment of Parkinson’s disease. NIH supported.• All work met pre‐established deadlines and purity specifications with zero failure• Solved an extremely difficult chemistry problem for a pharmaceutical partner, enabling synthesis of 60triazolopyridine antibacterials, named joint inventor on patent• Synthesis and isolation of 120 compounds within 6 months for biotech partner, explored astreatment for parasitic animal disease
  • Queen Mary, University Of London
    Postdoc
    Queen Mary, University Of London May 2001 - Nov 2001
    London, England, United Kingdom
    Postdoctoral Fellowship supported by the Engineering and Physical Sciences Research Council (EPSRC).• Investigated molecular gears as components for nanoscale systems• Developed asymmetric organometallic catalysts as chiral DMAP analogs
  • Cardiff University
    Postdoc
    Cardiff University Jan 2000 - Apr 2001
    Relocated to Queen Mary, University of London
  • University Of Ottawa
    Postdoc
    University Of Ottawa Dec 1997 - Dec 1999
    Ottawa, Ontario, Canada
    Postdoctoral Fellowship supported by the Natural Sciences and Engineering Research Council (NSERC) and the Environmental Science and Technology Alliance of Canada (ESTAC).• Achieved phosgene‐free, ‘green’ route to industrially important isocyanates• Explored palladium catalyzed ring‐opening of aziridines and azetidines with heterocumulenes togive biologically relevant heterocycles

David Butler Education Details

Frequently Asked Questions about David Butler

What company does David Butler work for?

David Butler works for Hongene Biotech Corporation

What is David Butler's role at the current company?

David Butler's current role is Chief Technology Officer.

What schools did David Butler attend?

David Butler attended University Of St Andrews, University Of St Andrews.

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