At CoED Biosciences we are designing and testing the Expansion and Differentiation Cell Factory (CoED-CF) which is a disruptive technology to purify, expand and differentiate cells in a closed system that can be scaled from the bench to the bedside. The CoED-CF mimics human lymphatics and can be used to imprint immune cells with a tissue homing phenotype.

Designing new strategies to enhance tumour immuno-therapy

I completed my PhD at Imperial College in 2011. In 2012 I moved to the William Harvey Research Institute at Barts and The London to take up a postdoctoral research associate position. I moved to the lab of Federica Marelli-Berg, here, together with a dedicated team, I was instrumental in finishing a project studying the effect of hepatocyte growth factor on T cells which was published in Immunity in 2017. The groups projects, funded by the British Heart Foundation, revolved around the mechanisms by which T cells interact with the heart and how these mechanisms change during disease and can be manipulated for therapeutic benefit. These studies, combined with a laudable effort from the whole group led to the publication of a paper in Circulation in 2022 (10.1161/CIRCULATIONAHA.121.055610) which is hoped will lead to a simple test for the diagnosis of myocarditis.I also co-authored several well received papers in Nature Communications, JEM and PNAS.

Tissue Culture, FACS analysis, Experimental design, analysing and presenting results, In Vivo techniques

In October 2003 I started work as a research assistant at the MRC clinical sciences centre at Hammersmith Hospital. I developed my lab based skills during our studies on the involvement of regulatory T cells (Treg) in transplant rejection. Our lab moved from the MRC to Imperial College in 2006 and I started my PhD in tumour Immunology in 2007.