Principal Scientist
Current
May 2024 - Present
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David Diguiseppi, Phd Email & Phone Number
Principal Scientist- Analytical Development and Quality Control
at
BioAnalysis, LLC
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Current company
Role
Principal Scientist- Analytical Development and Quality Control
Location
Philadelphia, Pennsylvania, United States
Who is David Diguiseppi, Phd? Overview
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David Diguiseppi, Phd is listed as Principal Scientist- Analytical Development and Quality Control at BioAnalysis, LLC, based in Philadelphia, Pennsylvania, United States. AeroLeads shows a matched LinkedIn profile for David Diguiseppi, Phd.
David Diguiseppi, Phd previously worked as Principal Scientist at Bioanalysis, Llc and Senior Scientist II/Principal Scientist at Passage Bio. David Diguiseppi, Phd holds Doctor Of Philosophy (Phd), Biophysical Chemistry And Biospectroscopy from Drexel University.
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BioAnalysis, LLC
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Profile bio
About David Diguiseppi, Phd
Driven Principal Scientist and Biophysical Chemist with extensive expertise in gene therapy, Analytical Development, Quality Control, and startups. Constantly exceeding industry experience expectations in leading biotechnology companies focused on rare diseases. Demonstrated expertise in analytical chromatography and biophysical methods, playing a pivotal role in their design and validation as an integral part of the Analytical and Technology Development division. I've been instrumental in establishing and managing Analytical Development and Quality Control labs, fostering collaboration with CDMOs and CROs, serving as the primary audit contact, and readily step into the role of Interim Associate Director as needed. Additionally have developed and optimized analytical and biophysical characterization methods based on biological/biochemical techniques to support AAV gene therapy vectors. Strong professional scientist at a gene therapy company with a Doctorate (PhD) focused in Biophysical Chemistry and Biospectroscopy from Drexel University.I have a demonstrated history of working in experimental spectroscopy and biophysical chemistry specialized in Size Exclusion Chromatography (SEC-MALS), Field-Flow-Fractionation (FFF-MALS), DLS, RP-HPLC, Peptide Mapping and Capsid ID, Ultra-Violet Electronic Circular Dichroism (UVCD or ECD), Vibrational Circular Dichroism (VCD), Infrared Spectroscopy, Fluorescence Spectroscopy, Raman Spectroscopy, NMR Spectroscopy. Skilled in CE-SDS, SDS-PAGE, GC/MS, Rheology, Atomic Force Microscopy (AFM), Scanning and Transmission Electron Microscopy (SEM and TEM), various light scattering techniques, various fitting programs, etc
Current workplace
David Diguiseppi, Phd's current company
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7 roles
David Diguiseppi, Phd work experience
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Senior Scientist Ii/Principal Scientist
- Served as Interim Associate Director multiple times throughout tenure.
- Managed a team of three varying level scientists through method development, OOS investigations, and data review for both AD and QC standards.
- Accountable for method development, method qualification, and tech transfer of AAV drug substance, drug product, and stability testing for phase 1/2 IND submissions.
- Facilitated the opening of the company’s inaugural Analytical Development and Quality Control lab facility, responsible for equipment procurement, vendor contracts, and method planning.
- Developed and validated physical chemistry analytical techniques for AAV gene therapy vectors, ensuring GMP compliance and alignment with regulatory guidelines including international affairs.
- Established as the team's subject matter expert for SEC-MALS, RP-HPLC, DLS, AUC, Peptide Mapping (BioAccord LC-MS), Capsid ID, and Pluronic assays (UPLC-CAD).
Jan 2023 - Jul 2023
Senior Scientist - Analytical Development, Biophysical
Jan 2022 - Dec 2022
Biophysical Scientist - Analytical Development
Mar 2021 - Dec 2021
Scientist, Analytical Development
As an Analytical Scientist in the Biophysics group within the Process and Technology Development Department, I - -Develop, validate, and optimize analytical and biophysical characterization methods to support rAAV process development and product characterization (including SEC-MALS, FFF-MALS, DLS, RP-HPLC, DSC)-Conduct analytical and biophysical.
Oct 2019 - Mar 2021
Graduate Research And Teaching Assistant
- PhD student in the Biophysical Chemistry group under the guidance of Dr. Reinhard Schweitzer-Stenner. Through my graduate career I:
- Explored spectroscopic and physical properties of small and medium peptide chain gelators
- Determined secondary structure of amino acids at different pH states in water and with the addition of cosolvents
- Explored the kinetic and thermodynamic properties of short peptide hydrogels formed by unlike co-solvents and pH states, and tune the formation by varying the parameters
- Determined the reversibility and reformation process of peptide gelators
- Mentored undergraduate students to explore the influence of co-solvents on the unfolded peptide conformation of peptides
Jul 2014 - Sep 2019
Undergraduate Researcher
- Performed research in the medicinal/bio-analytical lab of Dr. Catherine Yang. My duties were to:
- Determine the most efficient process to extract, separate, and purify urushiol from poison ivy utilizing GC/MS and NMR spectroscopy
- Collaborate with Dr. Robert Coifman at Allergy and Asthma of South Jersey to prepare a vaccination
May 2013 - Jan 2014
2 education records
David Diguiseppi, Phd education
Doctor Of Philosophy (Phd), Biophysical Chemistry And Biospectroscopy
Drexel University
Chemistry B.S.
Rowan University
FAQ
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Quick answers generated from the profile data available on this page.
What company does David Diguiseppi, Phd work for?
David Diguiseppi, Phd works for BioAnalysis, LLC.
What is David Diguiseppi, Phd's role at BioAnalysis, LLC?
David Diguiseppi, Phd is listed as Principal Scientist- Analytical Development and Quality Control at BioAnalysis, LLC.
Where is David Diguiseppi, Phd based?
David Diguiseppi, Phd is based in Philadelphia, Pennsylvania, United States while working with BioAnalysis, LLC.
What companies has David Diguiseppi, Phd worked for?
David Diguiseppi, Phd has worked for Bioanalysis, Llc, Passage Bio, Spark Therapeutics, Inc., Drexel University, and Rowan University.
How can I contact David Diguiseppi, Phd?
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What schools did David Diguiseppi, Phd attend?
David Diguiseppi, Phd holds Doctor Of Philosophy (Phd), Biophysical Chemistry And Biospectroscopy from Drexel University.
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