David Gerrish Email & Phone Number

Dayton, Oh, Us

Dayton, Ohio Area

Wright-Patterson Air Force Base, Ohio

Analytical chemist for SSI working for the Department of Defense at Wright Patterson Air Force Base, providing subject matter expert (SME) consultation related to Chemical, Biological, Radiological, Nuclear (CBRN) detection of contaminants found in environmental samples in air, water, soil and hazardous waste samples to facilitate the development of Health Risk Assessments. Providing the 711 HPW with SME reach back support to the Bioenvironmental Engineering (BEE) career field in support of… Show more Analytical chemist for SSI working for the Department of Defense at Wright Patterson Air Force Base, providing subject matter expert (SME) consultation related to Chemical, Biological, Radiological, Nuclear (CBRN) detection of contaminants found in environmental samples in air, water, soil and hazardous waste samples to facilitate the development of Health Risk Assessments. Providing the 711 HPW with SME reach back support to the Bioenvironmental Engineering (BEE) career field in support of real world analysis of environmental hazards. Show less

Senior Research Associate - January 2015 - Present Research Associate III - May 2011 - December 2014• Performed twelve to fifteen step syntheses of small molecules for inhibiting 5-HT2C receptors in the central nervous system• Designed and solved the challenges associated with scaling up 150 grams of material for toxicology studies avoiding the utilization of chromatography• Synthesized and characterized novel biological active 5-HT2C inhibitors which include core structures… Show more Senior Research Associate - January 2015 - Present Research Associate III - May 2011 - December 2014• Performed twelve to fifteen step syntheses of small molecules for inhibiting 5-HT2C receptors in the central nervous system• Designed and solved the challenges associated with scaling up 150 grams of material for toxicology studies avoiding the utilization of chromatography• Synthesized and characterized novel biological active 5-HT2C inhibitors which include core structures such as tricyclic and tetracyclic Benzazepine ring systems• Designed small molecules with the use of molecular modeling and SAR data• Performed chiral separation on all final compounds• Scale-up of stem cells from CF-10’s (2D) to 3.75 liter up to as large as 200 liter bioreactors (3D)• Implemented an environmental monitoring protocol in order to maintain a semi clean room• Assisted in designing the lab layout when we moved from one building to another in the fall of 2016• Directly involved in all of our large scale-up processes utilizing 200 liter bioreactors Show less

Research Associate III - July 2006 - March 2011Research Associate II - July 2004 - June 2006Oncology Projects• Designed small molecules with the use of molecular modeling and SAR data• Synthesized small molecules for Kinase inhibitors which showed potency and efficacy in cell based assay• Synthesized and characterized novel biological active compounds related to Topoisomerase II inhibition, which include core structures such as Purines, Pyrimidines, and Benzoxazole ring… Show more Research Associate III - July 2006 - March 2011Research Associate II - July 2004 - June 2006Oncology Projects• Designed small molecules with the use of molecular modeling and SAR data• Synthesized small molecules for Kinase inhibitors which showed potency and efficacy in cell based assay• Synthesized and characterized novel biological active compounds related to Topoisomerase II inhibition, which include core structures such as Purines, Pyrimidines, and Benzoxazole ring systemsAnti-Viral Project• Played a critical role in advancing the project form HTS to lead optimization and beyond • Independently conceived novel compounds and successfully executed SAR studies with the objective of improving in vitro potency and cell based anti-viral efficacy• Integrated modifications to lead compounds to improve PK and ADME properties• Designed synthetic routes for process scale• Synthesized numerous anti-viral compounds which are very potent and efficacious in cell based assay • Synthesized three compounds that were designated as potential drug candidates. One was declared an IND for HIV and the other two as back-up compounds. Show less

• Synthesized and characterized novel biological active compounds related to Topoisomerase II inhibition• Synthesized and characterized novel organic compounds related to Purine, Pyrimidines, and Benzoxazole Ring Systems• Utilized wet chemistry techniques, including but not limited to, column chromatography, MALDI-TOF MS, ESI-MS, HPLC, GC/MS, and NMR in the analysis of small organic compounds

• Provided instruction and assistance for multiple Organic Chemistry laboratory sessions• Participated in preparation of organic laboratory experiments• Provided Professor assistance in the area of grading classroom and laboratory assignments as well as exams

101St Airborne Division Fort Campbell, Kentucky

Ms, Organic Chemistry

Thesis: “Synthesis of UK-1 Analogs as Potential Topoisomerase II Inhibitors”.

Ba, Chemistry

Aa, Biology