David Pan Email & Phone Number

California, United States

Foster City, California, United States

San Francisco Bay Area

Clinical Bioinformatics Exploratory AnalyticsFocus on virology, HBV and COVID-19, and support of clinical trials and related exploratory/translational research

Greater Los Angeles Area

Ph.D. in BioinformaticsPart of Bioinformatics IDP ProgramDiscovered master TF regulators as drivers of gene co-expression networks important for central obesity and examined network heritability using PRS scores in a sex-specific mannerExamined cis-eQTLs from Finnish METSIM cohort adipose tissue RNA-seq and promoter capture Hi-C data in human white adipocytes to identify causal circuits involving genes related to obesity beyond those identified in GWASUsed promoter Capture Hi-C data to examine cis-regulatory effect of GTEx replicated cis-eQTLs in enhancersIdentified 42 independently-replicated genes in adipose tissue correlated with BMIDetermined causal regulatory pathways for 4 GWAS genes each with a single putatively causal cis-eQTL acting through looping regulatory elements of which gene expression levels are correlated with BMI

Nankang, Taipei, Taiwan Roc

Institute of Information ScienceBioinformatics LaboratoryInvestigated the presence and functional role of non-coding RNAs transcribed from enhancer regions (enhancer RNAs) in the genome with regards to gene regulation using computational methods across 12 mouse tissuesComputationally verified that across tissues enhancers exist in significant numbers in two states of transcribing and non-transcribing enhancersExamined differences between target genes of enhancers with and without enhancer RNAs showing that across tissues enhancer RNAs are related to higher expression levels of target genes by comparison of identical enhancer and target gene pairsCompared enhancer RNAs to other known non-coding RNAs using the Rfam database and theorized a functional mechanism for enhancer RNAs similar to microRNAs and non-coding RNA activators using target gene prediction toolCurrent investigation focuses on the functional mechanism and role of RNA modifications on the onset and development of cancer

Master's DegreeThesis: Physical Simulation of Variations in Nitrogen Content in Laser Welds of 21-6-9 Austenitic Stainless Steel Worked in close collaboration with Los Alamos National Laboratory, who sponsored the project, for the development of welding corrosion-resistant, nitrogen-enriched stainless steel commonly used for nuclear energy applications and proving the cost-effectiveness of investment in laser-welding systemImproved contemporary understanding and prediction methods of final nitrogen content in laser welds of stainless steel by developing a new rate law enabling better control of the welding parameters with potential benefits in weld strength and crack and corrosion resistanceDeveloped custom code in Fortran for the commercial software Flow3D by FlowScience, employing Volume of Fluid (VOF) simulation method to accurately model heat and pressure directed fluid flow, surface tension effects, and weld pool developmentConceived and applied discrete macro-particles representing nitrogen in alloy to track movement and loss rate of nitrogen with a reaction kinetics approachCollaborated with Colorado School of Mines to demonstrate simulation results matched experimental findings in terms of weld penetration depth and nitrogen loss

Columbus, Ohio Area

Welding Engineering 500/550Prepared and presented select lectures for class sessions with advice from the instructorLaboratory introductory presentations explaining purpose and objectives of experiments as well as underlying theory of the welding processesAdvised laboratory experiments and raised student interest in welding’s underlying concepts and attention to welding safety

Hsinchu, Taiwan

Medical Device and Biomedical Technologies DivisionParticipated in preliminary nerve regeneration experiments using the sciatic nerve of rats through in vivo partial enzyme digestion of ligated site using specially designed tubes to ensure enzyme digestion of only the intended siteExplored new methods to purify collagen cost effectively for use in scaffoldsContinued cartilage harvesting experiments from previous year

Berkeley, Ca

Planned and led problem-solving sessions for students taking physics working jointly with other study group leaders to prepare weekly worksheetsOrganized the writing of simulated midterms and finals and administered the mock tests followed with explanation of the solutionsWon teaching olympics competition requiring teams of two to teach a basic science topic using four everyday objects with thirty minutes for preparation

Hsinchu, Taiwan

Medical Device and Biomedical Technologies DivisionHarvested cartilage from fresh animal knees for in vitro cartilage regeneration experiment using variable time enzyme partial digestion and grew cartilage in a bioreactor resulting in successful regrowth and rejoining of severed cartilage bridging a gap larger than 3mm with the larger goal of performing in situ knee cartilage repair in pigs and humansExplored new methods to purify collagen effectively for manufacture of scaffolds to facilitate bone regenerationUsed poly(lactic-co-glycolic acid) to build scaffoldings to promote the regrowth of cartilage and bone as a potential alternative to full knee replacement surgery

Berkeley, Ca

Biology 1BMotivated undergraduate students undecided about their major to pursue the study of plants, evolution, and ecologyCollaborated with graduate student instructors to write weekly lab quizzes and give pre-laboratory presentations explaining the significance and key points about theAssisted students with laboratory techniques and experiments

Doctor Of Philosophy - Phd, Bioinformatics

Master'S Of Science, Welding Engineering, 3.799

Bachelor'S Of Science, Materials Science And Engineering, 3.16

Activities and Societies: Materials Science and Engineering Association, Student Learning Center (Physics Tutor/Study Group Leader).

Education record