David Peng Email & Phone Number

Houston, TX, US

Houston, TX, US

Houston, TX, US

Houston, TX, US

Tarrytown, New York, US

New York, NY, US

• Incorporated metabolomics and single-cell transcriptomics to identify changes in cancer NAD+ salvage pathway metabolism as a mechanism of immune evasion and immunotherapy resistance to validate NAMPT, CD38, HDACs, and.
• Applied multiplex and in vivo transgenic markers to study changes in tumor immune microenvironment and transcriptomics in minimal residual disease of mutant EGFR and KRASG12C lung cancers following treatment with.
• Collaborated with various biotech companies to validate investigational therapeutic compounds in genetically engineered murine models of lung cancer to assess efficacy, adverse events, and synergistic/additive drug.

Houston, TX, US

• Identified collagen as a biomarker to predict resistance to immunotherapies and validated LOXL2 and LAIR1 as potential therapeutic targets in combination with immunotherapies.
• Identified mechanism by which tumor-infiltrating Th17 cells secrete IL-17 and IL-22 to promote resistance to MEK inhibitors in combination with immunotherapy to validate a novel combinatorial strategy with IL-17.
• Utilized in vivo CRISPR screen data to identify synergistic therapeutic combinations targeting heterogeneous lung tumors.

Houston, Texas, US

• Identified crosslinked collagen as a prognostic marker of metastatic lung cancer and LOXL2 as a potential therapeutic target.
• Delineated changes in cell signaling patterns in mesenchymal lung cancer cells that confer resistance to MEK inhibition.
• Identified multiple pharmacological targets in combination with MEK inhibitors to overcome lung cancer drug resistance.
• Published research investigating lung cancer metastasis, drug resistance, and tumor immunology in multiple high-impact scientific journals.
• Successfully defended dissertation and obtained PhD degree in the field of Cancer Biology.

• Published research findings as co-author in July 2012 edition of Stem Cells and Development.
• Performed various molecular biology experiments and assisted in generation of various reagents and experimental data for publication.
• Independently worked on own research project to understand the role of heme oxygenase-1 on induced pluripotent stem cell generation.

• Established bench scale antibody purification station utilizing previously acquired knowledge/experience.
• Reduced laboratory purchasing costs of antibodies due to production/purification station.
• Maintained and genotyped knockout mice and updated mouse inventory database for experimental use.
• Performed numerous mice experiments utilizing drug delivery, surgical procedures, flow cytometry, and histology techniques to generate data for publication.

Ithaca, NY, US

• Created 3D tissue constructs with bovine cartilage cell-seeded hydrogel scaffolds for bone/cartilage regeneration.
• Developed novel cell-seeded 3D tissue constructs with distinct multicellular microdomains using tissue printing.
• Designed and executed various experiments that optimized hydrogel strength for tissue printing purposes.
• Full-authorship poster presentation of research findings at TERMIS Conference.
• Co-authorship of research findings in journal of Tissue Engineering, Part C.
• Successfully defended thesis and obtained Masters of Engineering degree in the field of Tissue Engineering.

• Managed development, production, and quality of bioproduct used to treat lethal marine virus.
• Maximized bioreactor yield and purity by applying research and engineering principles and techniques to production.
• Experimented with various mammalian, insect, yeast, and bacterial expression cell lines to reduce production costs.
• Experimented with column chromatography and optimized purification process.
• Completed epitope mapping research project that determined binding site of bioproduct on marine virus.
• Optimized quantitative real-time PCR protocol to screen for marine virus in experimental trial samples.

US

• Published research findings as co-author in March 2005 edition of Diabetes.
• Performed various molecular biology experiments and assisted in mice surgical procedures to generate data for publication.
• Validated heme oxygenase 1 (HO-1) knockout in mice for primary investigators in the lab to use in specific projects.

Doctor Of Philosophy (Phd), Cancer Biology

Master Of Engineering (Meng), Bioengineering And Biomedical Engineering

Bachelor Of Science (B.S.), Bioengineering And Biomedical Engineering