David Pool Email & Phone Number

TARGETING THE NLRP3 INFLAMMASOME IN AUTOINFLAMMATORY DISEASEUSING NOVEL THERAPEUTICS TO MODULATE THE DYSREGULATED CONNEXIN43 HEMICHANNELOver 23 million Americans are afflicted with sight-threatening disease. Leading causes of vision impairment and blindness in the USA are age-related macular degeneration and diabetic eye disease. Worldwide, the projected number of people with age-related macular degeneration is 196 million, increasing to 288 million by 2040.Chronic diseases, including many chronic sight-threatening diseases, are amplified and perpetuated by the inflammasome pathway of the innate immune system. With aging, it becomes more difficult for the body to shut down the inflammatory process. Activation and assembly of the inflammasome complex, a multiprotein oligomer of the innate immune system (as opposed to the adaptive immune system), promotes cleavage and secretion of pro-inflammatory cytokines interleukin 1β and interleukin 18, but also the release of other inflammatory cytokines, including VEGF.InflammX Therapeutics has highly differentiated, lead drug candidates based upon a novel mechanism of action called “Gap Junction Hemichannel Modulation.” InflammX technology shuts down inflammsome complex assembly by stopping release of the inflammasome activator signal, breaking the chronic cycle of inflammatory cytokine release, restoring the microvascular bed and promoting tissue repair. InflammX has potential treatments for multiple back-of-the-eye diseases and disorders, and is developing unique, patented therapeutics to treat ophthalmic diseases with high unmet needs that offer the potential to alter the standard of care.Based upon multiple pre-clinical studies, the company's technologies are expected to be transferable to other acute and chronic disease indications in which the inflammasome has been implicated.

Washington Dc, Us

USA Youth and High School Rugby is a 501(c)(3) non-profit organized in Washington, D.C. We are an affiliate of USA Rugby and are the Sanctioned Governing Body for all youth rugby in the United States and its Territories. This includes community and school based programs for players ages 5 – 18.MissionUSA Youth and High School Rugby exists to provide a fun and safe environment for the development of rugby in the United States; develop well rounded rugby community members both on and off the pitch; and be the conduit to connect the game at all levels to promote a lifelong love of the sport of rugby.VisionUSA Youth and High School Rugby seeks to celebrate, uphold and spread the Game of Rugby and its principles.

San Diego, Ca, Us

TARGETING THE NLRP3 INFLAMMASOME IN CORNEAL PERSISTANT EPITHELIAL DEFECTS USING A NOVEL THERAPEUTIC TO MODULATE THE DYSREGULATED CONNEXIN43 HEMICHANNEL NEXAGON, is a first in class unmodified antisense oligodeoxynucleotide that inhibits a cell membrane hemichannel forming protein, Connexin43 (Cx43). Cx43 is overexpressed after acute injury or in chronic disease states leading to pathological prematurely open hemichannels, allowing ATP to enter the extracellular space. Extracellular ATP triggers and perpetuates the immune system’s inflammasome pathway releasing multiple proinflammatory cytokines resulting in microvascular breakdown, vessel leak and limbal tissue ischemia. NEXAGON inhibits Cx43 overexpression and the inflammatory cascade, re-establishing limbal microvasculature and promoting regeneration of the corneal epithelium. Eyevance Pharmaceuticals, a Fort Worth-based pharmaceutical company committed to developing and commercializing innovative and impactful ophthalmic products, announced on October 2, 2018 a worldwide licensing agreement with OcuNexus Therapeutics for NEXAGON®, a 30 base antisense oligomer being developed for the orphan indication of persistent corneal epithelial defect (PED) nonresponsive to standard of care. NEXAGON® is currently in a Phase 3 study being conducted in the United States

San Diego, California, Us

Established in 2017, San Diego Legion is part of the professional Major League Rugby (MLR) organization, one of seven founding teams in North America. The MLR expanded to 9 teams in 2019. Our mission is simple, to introduce the culture of rugby to the local community and provide a conduit for education, inspiration and leadership through the sport. San Diego Legion reached the playoffs in 2018 and the Championship final in 2019.Both Championship finals have been held at the Legion home ground of Torero Stadium with a record 5,000 crowd in 2019 and the final watched by an estimated 750,000 people in the USA. In 2020 the MLR will expand to 12 teams in an East and West Conference. The 2020 season runs from February 2020 to the end of June 2020.

Southern California Youth Rugby (SCYR, Inc.) is the organizing body responsible for all youth and high school rugby in Southern California. Our region runs from San Luis Obispo in the north to San Diego in the south and includes all points east within the state of California.Elected as Treasurer in August 2016 and re-elected in July 2017 as President.SCYR, Inc. was created on January 18, 2006. Governed by a Council of member representatives, with Officers making up the Executive Committee, SCYR, Inc. was granted 501(c)3 non-profit, California corporation status in early 2012. A full-time Executive Director was hired in late August 2013 to manage the strategic growth of the organization and to supervise, direct and run SCYR's overall business and affairs, including day-to-day operations.As a State Rugby Organization (SRO), SCYR reports directly to USA Rugby, the sport's national governing body (NGB) and coordinates with Southern California Rugby Football Union (adult rugby).

OMNI’s proprietary robotic platform, OMNIBotics®, allows surgeons to conduct patient-specific total knee surgery designed to enhance patient satisfaction and reduce hospital costs. In addition, OMNI designs, engineers, manufactures and distributes a wide range of proprietary hip and knee implants and is focused on providing cutting edge technologies to transform outcomes in joint replacement surgery and enhance a surgeon’s ability to help patients live active and pain-free lives. In March, 2019 UK International orthopedic company Corin Group (“Corin“), backed by the Permira funds, acquired OMNI Orthopedics (“OMNI“), acccessing OMNI's robotic-assisted total knee replacement. It is further evidence of Permira and their co-investors’ determination to accelerate Corin’s strong organic growth with a focused M&A strategy.Founded in 1999 by a team of medical device engineers, OMNI is now at the forefront of robotic-assisted knee replacement. Their OMNIBotics® is a unique image-less total knee replacement solution which combines a robotic cutting guide with the world’s first robotic tool to measure ligament function. The system allows tailoring of the implant positioning to each individual patient, resulting in less patient pain and faster rehabilitation.OMNI’s CEO Rick Epstein commented: “It is the perfect time to be part of a larger organization that shares our dedication to improving the lives of individual patients through technological innovation. We are thrilled to be joining Corin to maximize the potential of our robotic solutions, adding another unique technology to their ecosystem”

The San Diego Youth Rugby Club "Mustangs" offers the opportunity for youth in the San Diego area, age 5 to 18, to experience and enjoy the sport of rugby. San Diego Youth Rugby strives to provide the highest standard and quality of coaching and teaching, to foster teamwork and to develop each player to the best of his/her potential in a fun and safe environment. All coaches, parents and players are mindful of the Mustangs playing in the spirit of the game and they emphasize sportsmanship. We have 7 divisions in our club (U8, U10, U12, U14, U16, U18, Girls U14). Each age grade is coached by USA Rugby registered coaches and include ex players from the USA, England, Wales, New Zealand and South Africa. We are affiliated with the Torrey Pines, La Jolla and Rancho Bernardo High School programs and bring these players together with other area High School players for a "club" season after their high school seasons are complete.San Diego Youth Rugby is affiliated with USA Youth and High School Rugby, a partner of the Positive Coaching Alliance.

Bachelor Of Commerce - Bcom, Accounting And Business/Management

Education record