David Winkler Email and Phone Number
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Broad project biology and small molecule and antibody therapeutic drug discovery experience from project inception through to early development. Significant contributions to projects in bone, inflammation, immunology, oncology, immuno-oncology, and neuro-degradation/neuro-inflammation therapeutic areas. Strong organizational leadership of groups and individuals, having built high-performing teams. The breadth and depth of experience needed to provide both the high level and very detailed guidance needed to drive discovery programs and translational programs. Strengths include project biology through DC selection, translational biology, pre-clinical pharmacology, disease and target engagement biomarkers, authoring of pharmacology and other appropriate sections for CTA, IND, IB and other regulatory submissions. Managed collaborations with key opinion leaders and academic collaborators. Utilized internal resources and a network of Contract Research Organizations (CROs) to achieve project goals. Participated in the due diligence process across multiple successful deals.My success has been documented as an author on impactful papers, patents, invited presentations, and importantly drug discovery programs that have progressed into and through development. Specialties: Antibody therapeutic discovery, protein therapeutic discovery, small molecule therapeutic discovery, biologics, inflammation, cancer, bone biology, Protein-protein interaction biacore, molecular biology, assay development, cell based assays, primary cell assays, enzymology, kinase, protein production, protein purification, pathway biology, HPLC, FPLC, ELISA, FRET, Lable free assays, High content assays (Cellomics).
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Executive Director BiologyIfm Therapeutics Jul 2019 - PresentBoston, Massachusetts, Us -
Senior Director ImmunologyIfm Therapeutics Oct 2017 - PresentBoston, Massachusetts, Us -
Director Of ImmunologyIfm Therapeutics Aug 2016 - PresentBoston, Massachusetts, UsTargeting innate immunity in immuno-oncology, auto-inflammatory, and auto-immune disease -
Research DirectorInfinity Pharmaceuticals Mar 2016 - Aug 2016Cambridge, Massachusetts, Us -
Associate Research DirectorInfinity Pharmaceuticals Feb 2011 - Feb 2016Cambridge, Massachusetts, UsTherapeutic discovery and development oncology and immune oncology -
Principal ScientistPfizer Oct 2009 - Apr 2010New York, New York, UsI have been a principal scientist at Wyeth and recently Pfizer in the Rheumatoid Arthritis and inflammation signaling groups. I have provided project and scientific leadership for several protein therapeutic discovery projects, including anti IL-7, anti-MIF, anti RAGE antibody and TREM-1, as well two projects for small molecule therapeutics including PKC epsilon kinase and the TLR4 receptor complex. I am responsible for target identification and have initiated four projects, and evaluated several external therapeutic antibody programs for potential in-licensing. Biologically, my group has focused on the link between the innate immunity and adaptive immunity, and the roles such targets have in chronic inflammatory disease. I have participated in alliances including that with Opsona therapeutics targeting Toll like receptors, and with Trubion evaluating alternative scaffolds for protein therapeutics. -
Principal ScientistWyeth Jul 2004 - 2009New York, New York, UsLeadership for small molecule and antibody drug discovery projects from target identification to development. -
ScientistCelltech R&D Feb 1999 - Jan 2004A leader in an effort to assess and establish function for a novel protein, sclerostin, identified by our group at Celltech. We established the biochemical and biological mechanism for Sclerostin, a key protein for the regulation of bone density, which provided the underpinning for a strategic collaboration with Amgen for the development a novel therapy for osteoporosis. I then led the discovery effort for antibody inhibitors of Sclerostin, leading to the discovery of therapeutic antibodies that are currently utilized for a bone anabolic therapy (Evenity).
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Postdoctoral FellowFred Hutchinson Cancer Research Center 1994 - 1998Seattle, Wa, Us
David Winkler Skills
David Winkler Education Details
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Harvard Medical SchoolBiochemistry -
Harvard UniversityCell Biology And Biochemistry -
Reed CollegeBiology
Frequently Asked Questions about David Winkler
What company does David Winkler work for?
David Winkler works for Ifm Therapeutics
What is David Winkler's role at the current company?
David Winkler's current role is Executive Director Biology at IFM Therapeutics.
What is David Winkler's email address?
David Winkler's email address is da****@****hoo.com
What is David Winkler's direct phone number?
David Winkler's direct phone number is .617.453*****
What schools did David Winkler attend?
David Winkler attended Harvard Medical School, Harvard University, Reed College.
What skills is David Winkler known for?
David Winkler has skills like Drug Discovery, Assay Development, Cell, Elisa, Protein Chemistry, Molecular Biology, Antibodies, Biochemistry, Inflammation, Biotechnology, Biomarker Discovery, Protein Purification.
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