David Winkler

David Winkler Email and Phone Number

Executive Director Biology at IFM Therapeutics @ IFM Therapeutics
David Winkler's Location
Greater Boston, United States, United States
David Winkler's Contact Details

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About David Winkler

Broad project biology and small molecule and antibody therapeutic drug discovery experience from project inception through to early development. Significant contributions to projects in bone, inflammation, immunology, oncology, immuno-oncology, and neuro-degradation/neuro-inflammation therapeutic areas. Strong organizational leadership of groups and individuals, having built high-performing teams. The breadth and depth of experience needed to provide both the high level and very detailed guidance needed to drive discovery programs and translational programs. Strengths include project biology through DC selection, translational biology, pre-clinical pharmacology, disease and target engagement biomarkers, authoring of pharmacology and other appropriate sections for CTA, IND, IB and other regulatory submissions. Managed collaborations with key opinion leaders and academic collaborators. Utilized internal resources and a network of Contract Research Organizations (CROs) to achieve project goals. Participated in the due diligence process across multiple successful deals.My success has been documented as an author on impactful papers, patents, invited presentations, and importantly drug discovery programs that have progressed into and through development. Specialties: Antibody therapeutic discovery, protein therapeutic discovery, small molecule therapeutic discovery, biologics, inflammation, cancer, bone biology, Protein-protein interaction biacore, molecular biology, assay development, cell based assays, primary cell assays, enzymology, kinase, protein production, protein purification, pathway biology, HPLC, FPLC, ELISA, FRET, Lable free assays, High content assays (Cellomics).

David Winkler's Current Company Details
IFM Therapeutics

Ifm Therapeutics

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Executive Director Biology at IFM Therapeutics
David Winkler Work Experience Details
  • Ifm Therapeutics
    Executive Director Biology
    Ifm Therapeutics Jul 2019 - Present
    Boston, Massachusetts, Us
  • Ifm Therapeutics
    Senior Director Immunology
    Ifm Therapeutics Oct 2017 - Present
    Boston, Massachusetts, Us
  • Ifm Therapeutics
    Director Of Immunology
    Ifm Therapeutics Aug 2016 - Present
    Boston, Massachusetts, Us
    Targeting innate immunity in immuno-oncology, auto-inflammatory, and auto-immune disease
  • Infinity Pharmaceuticals
    Research Director
    Infinity Pharmaceuticals Mar 2016 - Aug 2016
    Cambridge, Massachusetts, Us
  • Infinity Pharmaceuticals
    Associate Research Director
    Infinity Pharmaceuticals Feb 2011 - Feb 2016
    Cambridge, Massachusetts, Us
    Therapeutic discovery and development oncology and immune oncology
  • Pfizer
    Principal Scientist
    Pfizer Oct 2009 - Apr 2010
    New York, New York, Us
    I have been a principal scientist at Wyeth and recently Pfizer in the Rheumatoid Arthritis and inflammation signaling groups. I have provided project and scientific leadership for several protein therapeutic discovery projects, including anti IL-7, anti-MIF, anti RAGE antibody and TREM-1, as well two projects for small molecule therapeutics including PKC epsilon kinase and the TLR4 receptor complex. I am responsible for target identification and have initiated four projects, and evaluated several external therapeutic antibody programs for potential in-licensing. Biologically, my group has focused on the link between the innate immunity and adaptive immunity, and the roles such targets have in chronic inflammatory disease. I have participated in alliances including that with Opsona therapeutics targeting Toll like receptors, and with Trubion evaluating alternative scaffolds for protein therapeutics.
  • Wyeth
    Principal Scientist
    Wyeth Jul 2004 - 2009
    New York, New York, Us
    Leadership for small molecule and antibody drug discovery projects from target identification to development.
  • Celltech R&D
    Scientist
    Celltech R&D Feb 1999 - Jan 2004
    A leader in an effort to assess and establish function for a novel protein, sclerostin, identified by our group at Celltech. We established the biochemical and biological mechanism for Sclerostin, a key protein for the regulation of bone density, which provided the underpinning for a strategic collaboration with Amgen for the development a novel therapy for osteoporosis. I then led the discovery effort for antibody inhibitors of Sclerostin, leading to the discovery of therapeutic antibodies that are currently utilized for a bone anabolic therapy (Evenity).
  • Fred Hutchinson Cancer Research Center
    Postdoctoral Fellow
    Fred Hutchinson Cancer Research Center 1994 - 1998
    Seattle, Wa, Us

David Winkler Skills

Drug Discovery Assay Development Cell Elisa Protein Chemistry Molecular Biology Antibodies Biochemistry Inflammation Biotechnology Biomarker Discovery Protein Purification Drug Development Cancer Immunology Hplc Small Molecules In Vitro Biomarkers Lifesciences Cell Culture In Vivo Cell Biology Translational Medicine Pharmacology Clinical Development Animal Models Monoclonal Antibodies Biopharmaceuticals Protein Expression Drug Design Validation Target Identification Fplc Translational Research Flow Cytometry Genomics Lc Ms Biologics High Throughput Screening Purification Medicinal Chemistry Pharmacokinetics Adme Ind Lead Change Chromatography Proteomics Toxicology Drug Metabolism

David Winkler Education Details

  • Harvard Medical School
    Harvard Medical School
    Biochemistry
  • Harvard University
    Harvard University
    Cell Biology And Biochemistry
  • Reed College
    Reed College
    Biology

Frequently Asked Questions about David Winkler

What company does David Winkler work for?

David Winkler works for Ifm Therapeutics

What is David Winkler's role at the current company?

David Winkler's current role is Executive Director Biology at IFM Therapeutics.

What is David Winkler's email address?

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What is David Winkler's direct phone number?

David Winkler's direct phone number is .617.453*****

What schools did David Winkler attend?

David Winkler attended Harvard Medical School, Harvard University, Reed College.

What skills is David Winkler known for?

David Winkler has skills like Drug Discovery, Assay Development, Cell, Elisa, Protein Chemistry, Molecular Biology, Antibodies, Biochemistry, Inflammation, Biotechnology, Biomarker Discovery, Protein Purification.

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