Responsible for the design of the electrical architecture for the liquid handling portion of the Omega sequencer. The Omega sequencer is high trough put sequencer based on proprietary chemistry developed by Complete Genomics. Specified and designed a distribute set of electronics to control four different modules in the Omega sequencer. The modules included and interface module for connecting the consumable to the system, a low volume pipetting module including an x ,y, and z stage, a bulk reagent dispensing system, and a user input/output station. The system contains a combination of 22 of these modules.Specified, designed and wrote all firmware for the four modules. This includes developing a proprietary communication protocol for the system. The protocol was based around a CAN Buss architecture.Responsible for transferring the FPGA electronics from an outside vendor in house. Responsible for managing the elcetromechanical technicians for both the liquid handling and imager teams of the Omega sequencer project.

Lead Engineer for the RapidHIT 200 DNA fingerprinting system. The RapidHIT 200 uses STR polymorphisms to discriminate between individuals. I led a team of engineers and contractors to produce the first Beta units, test and characterize the units, and revise the units for release to our contract manufacturing partner. Responsible for designing the RapidHIT 200 instrument. This included designing the overall system architecture, creating and documenting subsystem and module specifications, and developing test plans and overseeing their execution. Worked with marketing, engineering and science teams to develop specifications for the subsystems and modules for the RapidHIT 200. Worked with engineering and science teams to develop test plans for validating subsystems, individual modules, and the complete system. Worked with operations and the contract manufacturer to ensure proper transfer from development into manufacturing. Responsible for directly managing the electrical engineering department consisting of two entry level electrical engineers, a Sr. firmware engineer, an electromechanical designer, and two electromechanical technicians.Responsible for acquiring NRTL and CE certifications for the RapidHIT 200 instrument.Responsible for development of IR based lysis heater. This included design of mechanical assembly, design of electronics and firmware, and system integration and verification and validation testing.

Sole electrical and firmware engineer responsible for designing, testing, and maintaining electrical systems for the Apollo 100 Sanger Sequencing and Apollo 324 Next Generations sample prep product lines.Designed sample dispensing system based on TECAN robot platform. This included specifying the hardware for the system, designing the algorithms for dispensing, designing the packaging for the reagents, and designing and performing engineering verification and validation tests.Responsible for engineering development verification of the Apollo 324 a next generation sample prep system.

Project manager for a microfluidic system for use in drug discovery.Worked with a small group developing a novel microfluidic system for proteomics. Responsible for systems integration of the microfluidic proteomics system.Designed, built, and tested entire electromechanical system for the microfluidic proteomics system.Wrote all firmware for the microfluidic proteomics system.Assisted in the transfer of the microfluidic proteomics system into manufacturing. Designed test fixtures and procedures for manufacturing.Worked with a small group developing a novel microfluidic system for enzymology. Provided expert opinion on specifications for the instrument.Wrote motion control firmware for the optics platform in the microfluidic enzymology system.Designed, built, and tested Xenon flash lamp electronics for the optics system.Designed, built, and tested fluorescence detection electronics for the optics system.

Developed instrumentation for use in drug discovery.Worked with a small group developing a novel microfluidic system for enzymology. Team leader for system integration and instrument automation. Supported further development of a custom software package for analyzing enzyme data collected from a microfluidic fluorescent detection system, including development of new analysis modules in C++. Analysis modules included algorithms for detecting and extracting raw data, multivariable nonlinear modeling of enzyme kinetics, and statistical analysis of experimental results. Provided technical support and user training for this microfluidic system.Designed, prototyped, and tested a piezoelectric sensor array for measuring and classifying the activity, physiological parameters, and behaviors of rodents for drug studies.MATLAB was used to analyze the data collected from a piezoelectric sensor array.

Worked with microfluidic technologies including microfluidic chips, interconnects and fluid delivery systems.Worked with fluorescent detection systems for performing biological measurements.Simulated the microfluidic fluid delivery system with MATLAB and Simulink.LabVIEW was used for instrumentation integration, automation, and data acquisition.Performed simple mechanical prototyping with a mill, lathe, and laser cutting system.

Performed validation of new instrumentation and reconfigured instrumentation for testing birth control devices.Wrote and updated program code for lab instrumentation, Allen Bradley Controllers, and a custom database.Serviced and maintained HP/Agilent HPLC machines and other laboratory equipment.

Worked with technologies for high throughput screening of nucleic acids.Developed firmware for a custom instrument capable of electrochemical measurements for high throughput screening of nucleic acids. Developed validation and testing procedures for the above instrument to perform Failure Mode and Effects Analysis (FMEA) on the instrument. The analysis provided information on the possible failure modes, the likelihood of such failures, and the severity of a failure and its effect on the instrument. Designed and prototyped a high-density interconnect scheme for quartz micro-arrays containing multiple microelectrodes in a 96 well micro titer plate format. Materials used in the design included Kapton™, Pyralux, 3M anisotropic conducting films, and heat seal connectors.Worked to resolve manufacturing and electro-chemical issues concerning the surface characteristics of microelectrodes and different microelectrode geometries.Worked to resolve manufacturing and electro-chemical issues resulting from the use of systems for dispensing DNA probes onto quartz micro-arrays.Used AutoCAD to draw photolithographic and metal deposition masks and printed circuit boards.

Planned and conducted biological and medical research experiments dealing with the study of indoor air quality and use of electronic nose technologies for the detection and classification of microbiological contaminants.Evaluated techniques for the extraction and dimensionality reduction of raw data from the electronic nose sensory array. Various pattern recognition techniques were used to classify the extracted data sets and the results were compared. All the data analysis was performed using code written in MATLAB.Acquired microbiological laboratory skills for the growth, preservation, and identification of microorganisms.

Designed, fabricated, and tested analog and digital electronics for medical research. This included filtering and signal conditioning circuitry, analog-to-digital and digital-to-analog sampling circuitry, and sensor integration and measurement circuitry. SPICE® was used to model, simulate and analyze these systems. Various micro-controllers were also programmed and interfaced to the above circuitry for stand-alone and real-time operation.Prepared Printed Circuit Board (PCB) layouts using CIRCAD. Component specification, vendor selection, and cost analysis were performed for each PCB. Chassis selections, front panel layouts, back-plane designs, and specification of interconnect schemes and power distribution systems were also conducted. Soldered both surface mount (SMT) and pin through hole (PTH) packages. Digital signal processing, pattern recognition, and advanced control system algorithms were programmed and implemented using National Instruments LabVIEW, MATLAB, ANSI C, and C++. Designed thin and thick film microelectrodes, using Ledit, for use in medical research. Constructed interconnect schemes for testing the microelectrodes and performed impedance characterization on the microelectrodes.Design projects included an electronic nose for the detection and classification of odors, a portable anti-stuttering device, a 64 channel EKG/ECG bench top instrument, an implantable cardiac waveform measurement and steering device, and various microelectrode design projects.