David Hanzel Email & Phone Number

San Francisco, California, United States

Once again Biology amazes me with “obvious when you see it” solutions to complex challenges; how do our cells assemble multiprotein complexes? Probably not random, why not study how viruses hijack our system to assemble themselves? New results recently posted on bioRxiv describe the discovery and optimization of “assembly modulators” that effectively inhibit all pathogenic respiratory viruses. Yes, a pan-respiratory antiviral therapeutic; the paper is not an easy read, but totally worth it.… Show more Once again Biology amazes me with “obvious when you see it” solutions to complex challenges; how do our cells assemble multiprotein complexes? Probably not random, why not study how viruses hijack our system to assemble themselves? New results recently posted on bioRxiv describe the discovery and optimization of “assembly modulators” that effectively inhibit all pathogenic respiratory viruses. Yes, a pan-respiratory antiviral therapeutic; the paper is not an easy read, but totally worth it. I voted with my feet and joined PRAV Bioscience to validate the safety and efficacy of these compounds in humans.David found his next, even cooler, science gig!Find the bioRxiv paper at https://www.biorxiv.org/content/10.1101/2021.01.17.426875v3 Show less

Palo Alto, Ca

Technical and market diligence for a variety of foreign and domestic, acquiring, investing or developing companies.Scientific, operational and market consulting for several seed-stage companies.

Palo Alto, California, United States

The objective of the Alcon Seed Fund is to enable early-stage innovations to transform how ocular disease is managed. My job is to scout for such innovations (talk to strangers about science) and diligence relevant opportunities (learn new stuff), pretty good fit for me. Do you have an innovative technology or idea to improve vision care, Alcon Seed Fund is here to help, ping me.

San Francisco Bay Area

Naked Biome identified, developed and tested a topical probiotic to treat acne vulgaris in FDA regulated human clinical trials. Classical translational science, we confirmed our three hypotheses:1. Can a probiotic change the skin microbiome? Yes!2. If the skin microbiome is changed toward more commensal bacteria will acne improve? Yes!3. Is such a product/therapy patentable? Yes! In a startup everyone does everything; I was responsible for the science, safety, shipping and… Show more Naked Biome identified, developed and tested a topical probiotic to treat acne vulgaris in FDA regulated human clinical trials. Classical translational science, we confirmed our three hypotheses:1. Can a probiotic change the skin microbiome? Yes!2. If the skin microbiome is changed toward more commensal bacteria will acne improve? Yes!3. Is such a product/therapy patentable? Yes! In a startup everyone does everything; I was responsible for the science, safety, shipping and dishwashing. To spec, on time and under budget. Show less

Palo Alto, Ca

Metabiomics is an early stage molecular diagnostics company that is developing a non-invasive test for colorectal polyps and cancer that is based on human microbiome biomarkers, next-generation DNA sequencing and bioinformatics. I was responsible for all aspects of our first Clinical Study MB-01 (see below).We completed the study and robustly quantified performance on schedule and a shoestring budget. When in doubt measure it.

Menlo Park, Ca

X/Seed Capital is an independent, seed-focused early stage venture fund, providing first capital in to grow de novo start-ups from seed to success. My role was to source opportunities, advocate investment and to help portfolio companies achieve optimal milestones.• Major focus: early stage life science technology (diagnostics and medical devices), synthetic biology material science.• Board Director: CellScape and GeneWeave (acquired by Roche)• Board Observer: Allopartis… Show more X/Seed Capital is an independent, seed-focused early stage venture fund, providing first capital in to grow de novo start-ups from seed to success. My role was to source opportunities, advocate investment and to help portfolio companies achieve optimal milestones.• Major focus: early stage life science technology (diagnostics and medical devices), synthetic biology material science.• Board Director: CellScape and GeneWeave (acquired by Roche)• Board Observer: Allopartis (acquired by Novozymes)• Technical Advisor to the Board: DigitAB, OPX (acquired by Cargill), Hourglass, Bio Architecture Lab & NanOasis Show less

Menlo Park, Ca

In addition to standard customer-centric product marketing (including market, product definition) & original logo I:1. Managed research-stage reagent group that included: nucleotide synthetic chemistry, fluorescent dye chemistry, molecular biology, protein production and purification, pre-steady-state enzyme kinetics.2. Managed research-stage nanofabrication and surface chemistry group that included: nanostructure fabrication, nanoscale surface modification and active enzyme… Show more In addition to standard customer-centric product marketing (including market, product definition) & original logo I:1. Managed research-stage reagent group that included: nucleotide synthetic chemistry, fluorescent dye chemistry, molecular biology, protein production and purification, pre-steady-state enzyme kinetics.2. Managed research-stage nanofabrication and surface chemistry group that included: nanostructure fabrication, nanoscale surface modification and active enzyme immobilization. Show less

Sunnyvale, Ca

Five company namessame phone number.Pre-IPO to one of 68,000 @ GEHCI had a significant role in the development of a variety of platforms dependent on quantitative fluorescent detection, including:• Confocal-microscopy (high-throughput high-content screening and diffraction limited), • DNA sequencing (single molecule and capillary/Sanger), • Microarray (hardware, arrays and analysis)

Co-founder of wholly-owned spinout for human gene discovery. Built groups and systems to support multiple clinical collaborations and scores of patents.

San Francisco, Ca

I characterized phosphate metabolism (inorganic to ATP) in amphibian and mammalian gastric mucosa, isolated functional gastric glands and learned to do careful quantitative science, publish and present.

Ph.D., Physiology

I identified Ezrin as the key phosphorylated protein in the gastric acid secretion stimulus signaling pathway. I also learned.

Post Doc, Cell Biology

I identified the trans-golgi network visually and biochemically as the organelle where apically and basolaterally bound proteins diverged.

B.A., Physiology

Activities and Societies: DKE (when it was coed), Crew (Lightweight)