David Bauman work email
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David Bauman personal email
I am a highly motivated individual with experience in many different scientific fields including pulmonary hypertension, heart failure, fibrosis, immunology, cell biology, molecular biology, enzymology and steroid biochemistry. These diverse experiences have made me a well rounded and adaptive scientist. My professional goal is to work at the interface between biology and drug discovery; however, my background is indicative of my ability to branch out into other scientific avenues. I have held many roles including project leader with a proven track record in all stages of drug discovery and development, bringing three compounds to first-in-human clinical studies; highly collaborative, energetic, and goal-oriented scientist with exceptional leadership skills; self-starter and proven motivator; excellent verbal, written and interpersonal communication skills and mentor to many scientists.
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Executive DirectorSchrödingerPhiladelphia, Pa, Us
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Head Of Cardiovascular DiscoverySchrödingerGreater Philadelphia
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Senior Director, Cardiovascular DiseaseThe Janssen Pharmaceutical Companies Of Johnson & Johnson Apr 2022 - PresentRaritan, New Jersey, Us -
Head Of Pulmonary Hypertension DiscoveryThe Janssen Pharmaceutical Companies Of Johnson & Johnson Jul 2020 - May 2022Raritan, New Jersey, Us
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Director Of Vascular BiologyJanssen Inc. Sep 2017 - Jul 2020Toronto, Ontario, Ca -
DirectorMerck Dec 2016 - Aug 2017Rahway, New Jersey, UsCardiovascular discovery -
Principal ScientistMerck Jan 2016 - Dec 2016Rahway, New Jersey, UsCardiovascular Discovery, Pulmonary Hypertension Lead
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Associate Principal ScientistMerck Aug 2013 - Dec 2015Rahway, New Jersey, UsCardiovascular Discovery Team Member
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Senior Research BiologistMerck Oct 2009 - Jul 2013Rahway, New Jersey, UsCardiovascular Discovery Team Member
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Postdoctoral FellowUt Southwestern Medical Center Oct 2005 - Dec 2009Dallas, Texas, UsIdentifying the Biological Function of Cholesterol 25-Hydroxylase (CH25H) CH25H catalyzes the hydroxylation of cholesterol producing 25-hydroxycholesterol, an oxysterol that is a potent regulator of cholesterol biosynthesis and other cellular functions. As a postdoctoral fellow, my project was to elucidate the biological function of CH25H. I found that CH25H was induced in immortalized and primary macrophages when these cells were challenged with pathogens that activate toll-like receptors. A line of CH25H knockout mice exhibited elevated immunoglobulin A (IGA) levels versus wild-type controls suggesting that 25-hydroxycholesterol might be an immunomodulatory sterol. To test this idea, I established an in vitro system in which naïve B cells are stimulated with cytokines to switch production of immunoglobulins from the IgH/IgM class to to IgA. Experiments with this system showed that 25-hydroxycholesterol potently inhibited class-switch recombination (CSR) by naïve B cells by abrogating the transcriptional induction of activation-induced cytidine deaminase (AID), an enzyme required for CSR. The inhibition of 25-hydroxycholesterol was specific for B cells and did not inhibit T cell proliferation or T cell secretion of cytokines. My data indicate that activation of the innate immune system through macrophage toll-like receptors leads to the synthesis and secretion of 25-hydroxycholesterol, which in turn regulates the production of immunoglobulins by B cells of the adaptive immune system.
David Bauman Skills
David Bauman Education Details
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The University Of Texas Southwestern Medical SchoolMolecular Genetics -
University Of Pennsylvania School Of MedicinePharmacology
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University Of Pennsylvania School Of MedicineBiol
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Rensselaer Polytechnic InstituteBiology
Frequently Asked Questions about David Bauman
What company does David Bauman work for?
David Bauman works for Schrödinger
What is David Bauman's role at the current company?
David Bauman's current role is Executive Director.
What is David Bauman's email address?
David Bauman's email address is da****@****rck.com
What schools did David Bauman attend?
David Bauman attended The University Of Texas Southwestern Medical School, University Of Pennsylvania School Of Medicine, University Of Pennsylvania School Of Medicine, Rensselaer Polytechnic Institute.
What are some of David Bauman's interests?
David Bauman has interest in Immunology, Basketball, Molecular Genetics, Hockey, Pharmacology.
What skills is David Bauman known for?
David Bauman has skills like Drug Discovery, Pulmonary Hypertension, Pulmonary Diseases, Team Leadership, Pharmacology, Collaborative Leadership, Inhalation, In Vivo, In Vitro, Small Molecules, Heart Failure, Biochemistry.
Who are David Bauman's colleagues?
David Bauman's colleagues are Emily Rhodes, Basaveswar Kureti, Sayantan Mukhopadhyay, Heather Suto, Jessica Roberts, Jarrett Johnson, Dr. Abhijit Kayal.
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