David Ross Email & Phone Number

Cary, NC, US

Summary: Develop and test new biological entities to support the Talecris pipeline. Mentor, supervise and manage other laboratory scientists and scientific experiments to develop high-expressing cell lines and production of novel recombinant proteins. Implement molecular/cellular methods for analysis, high-throughput screening, and scale-up expression.

• Summary: Utilization of RNA interference (siRNA) for novel target identification, target and compound validation.
• Drive target identification and target validation for novel therapeutics using RNA interference (siRNA), from both internal siRNA screening and published literature.
• Responsible for applying scientific knowledge to develop project strategies and priorities with other project leaders in a fast paced industrial environment.
• Supervise and mentor student interns
• Provide support for and collaborate with teams of biologists and chemists across multiple therapeutic areas within GlaxoSmithKline, by performing experiments to address critical questions related to therapeutic targets.
• Utilize siRNA for validation of and determining specificity of novel chemical entities.

• Summary: Image-based high content, high throughput screening of small molecules and siRNA. Development and implementation of stem cell technologies in screening.
• Supervised 2 direct reports.
• Project leader responsible for development, validation, and scale-down of cell-based assays for high throughput, high content screening in collaboration with therapeutic groups at other MRL sites.
• Performed small molecule screens for identification and evaluation of novel chemical entities. Performed full genome siRNA screens for identification of novel therapeutic targets.
• Acted as project leader for development and implementation of novel stem cell technologies within Merck. Functioned as a primary liaison for collaborations between Merck and Stem Cell Sciences (Cambridge, UK).
• Acted as lead biologist in collaboration of Merck, Intel, and Carnegie Mellon Univ. for development of data mining, image analysis software, and computer architectures.

• Summary: Notch Signaling in cancer and cell differentiation.
• Acquired grant funding to support research efforts - American Cancer Society: the IDEC/Genentech/Ronald Levy Postdoctoral Fellowship (2002-2004: “Novel Targets of Notch Signaling” PF-02-120-01-LIB) - University of.
• Research Area: Cell differentiation and transformation mediated by Notch signaling - Characterized the roles of Notch and Hes-1 (a Notch responsive gene) in adipogenesis and osteoblastogenesis - Identified genes.
• Supervised laboratory research of graduate students

Phd, Molecular And Cellular Biology

Bs, Marine Biology