Daxeshkumar P. Email & Phone Number

Bethesda, Md, Us

Maryland, United States

Bethesda, Md 20892

I am involved in many aspects of omics-based cancer research including investigating the mechanisms of chemical carcinogenesis in various murine models using targeted and untargeted metabolomics. I have expertise using different mass spectrometry techniques (LC-MS, LC-Tof-MS and GC-MS), metagenomics, and the Clearlab base bio-analysis. I came to the NCI with the purpose to increase my skills and strengthen his scientific repertoire. In the area of cancer metabolomics, we have discovered that a novel combination of four urinary cancer biomarker metabolites - Creatine Riboside (CR), N-Acetylneuraminic acid (NANA), Cortisol Sulphate (CS) and chemically unidentified fragment 561+ m/z ion and their further investigation and mechanistic studies fitted precisely the goals of mine. Since beginning my fellowship in NIH, I significantly contributed to the metabolomic studies of exposure and biological functional studies for newly identified urinary biomarkers in different stages of human lung and liver cancer. I am also gaining expertise in using both liquid and gas chromatography linked to mass spectrometers as analytical platforms to investigate P450- and nuclear receptor-null mice and various humanized mouse models to discover endogenous and chemical biomarkers for the expression of individual P450s and nuclear receptor activation. Furthermore, I have investigated biomarkers of liver and lung diseases including cancer to better understand mechanisms of toxicity and carcinogenicity. Importantly, I have discovered the chemical identification of the previously unknown 561+m/z ion (NCPG) cancer biomarker. In addition, I am mentoring several visiting guest scholars in the use of mass spectroscopy and is involved with various additional projects in a lab focusing on cancer metabolomics.

Fuzhou, Fujian, China

Participate in all research that focuses on cancer metastasis alert and prevention. New drug development projects. Nanomedicine, Cyp450 metabolism, Scientific publications, and academic activities.

Ahmedabad Area, India

• Cost-effective method development, validation and study sample analysis for drugs of various therapeutic categories like Antidepressant, Antihypertensive, Antianginal, Antiviral, Analgesic Diuretics, etc.• Expertise in operating LC-MS/MS (Model: API 3000, 4000, 4500, 5000 and latest 5500, Software: Analyst 1.4.2, 1.4.2 and 1.5.1) from AB SCIEX, troubleshooting, data handling, and interpretation.• Handling specific regulatory audit of the United States (USFDA), WHO, Anvisa, France (AFSSAPS), Australia (TGA) and South Africa (MCC). • Preparation and review of SOPs and overall lab delegation in-charge.• To ensure effective implementation of GLP norms and proper follow up of In-house SOPs.• Proactively collaborated with inter-department to achieve continuous process improvement.• Study sample analysis of various drugs and/or their active metabolites by using different methods according to GLP guidelines and In-house SOPs for various regulatory submissions for USFDA, WHO, ANVISA, TGA, MCC, AFSSAPS ANDA & NDA filing. • Responsible for initiating and handling the project within the timelines and reporting deadlines and reviewing the final study data for pilot and pivotal projects.• Provided scientific and technical leadership and mentoring and guidance to the teammates and group members and to achieve the set targets.• Imparting training to new entrants as well as subordinates regarding different aspects of bioanalytical work. Responsible for investigation of out of specification results.

Ph.D. ; Clia Lab-Based Bio Analysis For Small Molecules And Its Metabolites. Targeted Metabolomics., Bio-Analytical Chemistry

M.Sc, Analytical Chemistry