Jane Coffin Childs Postdoctoral Fellow
CurrentOur understanding of how genomes control biological function is limited by our ability to make modifications and test hypotheses. As it becomes cheaper and faster to both chemically synthesize DNA and to read from cells with next-generation sequencing, we can identify relationships between DNA sequences and cellular outcomes at an unprecedented scale. This large amount of high-dimensional data can be combined with advancements in artificial intelligence to rapidly predict phenotypes and generate new sequences to test.As a Jane Coffin Childs Postdoctoral Fellow at UCSF, I’m currently applying these high-throughput synthetic approaches to engineer T cells for the treatment of cancer and autoimmune disease. I’m working in the Bluestone, Roybal, and Marson labs.
