Daniel Chen Email & Phone Number

California, United States

San Carlos, California, Us

- Led external collaborations, involving scoping, budgeting, development, execution, analysis, and delivery of AI-optimized high content imaging experiments and data- Goals of collaborations included MoA characterization, high-throughput screening, preclinical modeling and biomarker discovery- Pitched Spring's AI-based SaaS platform to potential partners and customers to secure partnerships and contracts- Worked closely with partner companies / SaaS customers and internal ML team to answer develop AI platform and answer biological questions- Managed a team of scientists to develop, execute, and analyze internal and external cell-based high content imaging experiments

San Carlos, California, Us

- Collaborated on cross-functional teams with biologists and machine learning engineers to execute external partnership projects, internal R&D projects, and build an AI-based custom imaging analysis SaaS product- Developed, executed, and analyzed AI-optimized cell-based assays using primary human cells- Facilitated interactions between partner companies and internal ML engineers and designers to translate biological questions into AI software features- Conceived and led an Incucyte-based experiment to characterize the process of iPSC reprogramming with AI- Served as an internal user of AI software to analyze internal projects and help develop SaaS platform- Trained, directed, and oversaw the experimentation of junior level research scientists

San Carlos, California, Us

- Developed a cell-based, high-content imaging phenotypic assay and high-throughput screen for inflammasome activation and inhibition in primary human PBMCs, resulting in a first-author publication - Elucidated mechanism of action/signaling pathways of small molecules by comparing their phenotypic and cytokine profiles with those of control compounds across biological pathways using machine learning approaches- Developed biochemical and cellular assays to validate screen hits- Designed cell-based high-content imaging experiments leading to machine learning models capable of age-based classification and cell pathway/MoA determination in multiple human cell types- Executed high content imaging experiments using human primary cells to discover drugs for age-related diseases- Collaborated on cross-functional teams with biologists and machine learning engineers- Directed a team of 2-4 scientists to execute team-based experiments

Stanford, Ca, Us

- Studied epigenetic memory in muscle stem cell function during regeneration

La Jolla, Ca, Us

- Established a link between the epigenetic clock and age-related eye disease in mice, resulting in a first-author publication and patent- Gained experience in mouse models. Assessed aging phenotypes and eye anatomy/function in CRISPR-KO mice- Identified a novel method to rejuvenate aged fibroblasts using a derivative of vitamin C, resulting in a patent- Gained extensive experience in mammalian cell culture and assay development- Developed expertise in biochemistry, molecular biology, and cell biology - Mentored and trained five undergraduate researchers- Taught two genetics courses as a teaching assistant

Denver, Colorado, Us

- Assisted in the creation of an optogenetic tool based on cellular secretion, resulting in a first-author publication

Berkeley, Ca, Us

- Investigated effects of extracellular matrix composition on myoblast markers- Assisted in the development of a platform for programming custom regulatory functions in E. coli

- Investigated receptor translocation in cancer cells

Doctor Of Philosophy - Phd, Biological And Biomedical Sciences

B.S., Bioengineering