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Cancer biologist with a primary interest in Target ID, Validation & Drug Discovery• Currently the biology and in vivo pharmacology lead of a multidisciplinary oncology program in pre-clinical drug discovery stage.• Previously: designed and lead the biology efforts of a multidisciplinary project in early discovery and hit finding stage. Also, lead biology and in vivo pharmacology efforts of a project at clinical development stage: Designed and executed in vitro and in vivo studies to demonstrate the mechanism of action and efficacy of a clinical stage drug in new indications.• 4 years of expertise in Target ID, Validation efforts in apoptosis pathway, E3-ubiquitin ligase, targeted protein degradation, functional genomic tools, and screening techniques (with Dr. William Sellers at Broad Institute).• 8 years of experience in signaling, genetic, and epigenetic regulation of cancer initiation, evolution, metastasis and drug resistance (with Dr Raffaella Sordella at CSHL).• Consistent track record of scientific excellence, as demonstrated by publications.• A thoughtful mentor helping junior scientists and colleagues develop their projects and careers.• Experience with managing multiple industry collaborations.
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Principal ScientistTasca TherapeuticsCambridge, Ma, Us -
Senior Scientist IRelay Therapeutics Dec 2023 - PresentCambridge, Ma, Us -
Scientist LlRelay Therapeutics Nov 2021 - Dec 2023Cambridge, Ma, Us• Served as the biology lead of a multidisciplinary project in early discovery and hit finding stage.• Served as the biology lead of a project at clinical development stage: Designed and executed in vitro and in vivo studies to demonstrate the mechanism of action and efficacy of a clinical stage drug in new indications. -
Postdoctoral Research AssociateBroad Institute Of Mit And Harvard Oct 2017 - Nov 2021Cambridge, Ma, Us• Discovered a novel, druggable E3-ubiquitin ligase regulator of apoptosis: 1) Demonstrated the mechanism of action of the E3 by using biochemical, genomic, molecular biology and in vivo techniques. 2) Determined a peptide sequence able to inhibit the novel E3 leading to induction of apoptosis. 3) Identified biomarker and determined lineage specificity for synergism of the novel E3 with current BH3 mimetic therapeutics. 4) Collaborated with several academic labs and platforms at Broad Institute to perform experiments key to the project: Protein purification, BH3 profiling assay, IP/Mass Spec, TCR-T-cell mediated cytotoxicity assay.• Received 2021 - Harry J Lloyd Charitable Trust Melanoma Research Career Development Grant• Coordinated meetings and presented data at Pharma-Broad collaboration meetings.• Supervised, trained, and completed performance reviews of two junior scientists.Mentor: Dr. William R. Sellers -
Doctoral StudentCold Spring Harbor Laboratory Feb 2012 - Oct 2017Cold Spring Harbor, New York, Us• Discovered a novel regulation of DNA double strand break repair pathway mediated by TGF-beta, causing tumor heterogeneity and drug resistance in NSCLC.• Studied function of novel TP53 exon-6 truncating mutations.• Studied epigenetic switch of drug resistant population in NSCLC• Created a rapid and tunable Cas9 stabilization system with precise editing ability. PhD Thesis advisor: Dr. Raffaella Sordella, 2012-2017 -
Graduate Student In Molecular And Cellular Biology ProgramStony Brook University Aug 2010 - May 2017Stony Brook, Ny, Us• 2011-2011: Studied contribution of EGFR and PI3K activity in KRAS mutant pancreatic cancer progression (PI: Dr. Howard Crawford).• 2010-2011: TA for BIO311(DNA Recombination Lab) and BIO365(Biochem Lab). -
Graduate Research Assistant/ Teaching AssistantKansas State University Aug 2008 - Jul 2010Manhattan, Ks, UsCharacterized the role of a novel microtubule destabilizing factor termed CCDC69 in controlling the assembly of central spindles and the recruitment of midzone components.MS thesis advisor: Dr. Qize Wei -
Research AssistantUniversity Of Calcutta, Department Of Biochemistry Sep 2007 - Apr 2008InWorked on the project 'Gold Nano Particle mediated cellular response' with Dr. Anjan Dasgupta, Professor, Dept of Biochemistry, university of Calcutta -
Summer Project TraineeSaha Institute Of Nuclear Physics, India May 2006 - Aug 2006Worked on characterization of Heat stable Cyclin dependent Kinase Inhibitors fromLeishmania donovani with Dr. Partha Saha
Debjani Pal Skills
Debjani Pal Education Details
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Stony Brook UniversityCell/Cellular And Molecular Biology -
Kansas State UniversityBiochemistry; Mentor Dr. Qize Wei -
Bethune CollegeBotany
Frequently Asked Questions about Debjani Pal
What company does Debjani Pal work for?
Debjani Pal works for Tasca Therapeutics
What is Debjani Pal's role at the current company?
Debjani Pal's current role is Principal Scientist.
What is Debjani Pal's email address?
Debjani Pal's email address is dp****@****ute.org
What is Debjani Pal's direct phone number?
Debjani Pal's direct phone number is +151677*****
What schools did Debjani Pal attend?
Debjani Pal attended Stony Brook University, Kansas State University, Bethune College.
What skills is Debjani Pal known for?
Debjani Pal has skills like Biochemistry, Molecular Biology, Western Blotting, Pcr, Cell Biology, Cancer Research, Protein Chemistry, Protein Expression, Genetics, Molecular Cloning, Teaching, Cell Signaling.
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