Deepak Unni Email & Phone Number

Basel, Switzerland

Working as Scientific Coordinator in the Personalized Health Informatics (PHI) group at the Swiss Institute of Bioinformatics (SIB) where I am primarily involved in the activities of the Swiss Personalized Health Network (SPHN).

Heidelberg, Baden-Württemberg, Germany

German Human Genome-Phenome Archive- Part of the Architecture Working Group for building services that serve the GHGA platform- Part of the Metadata Task Force to build, curate, and maintain a FAIR metadata schema for GHGA

Berkeley, Ca

Worked as a Software Developer at Berkeley Bioinformatics Open-source Projects (BBOP) group where I was involved in the following projects:- Monarch Initiative- Gene Ontology- Biomedical Data Translator- KG-COVID-19- Illuminating the Druggable Genome- National Microbiome Data Collaborative

Columbia, Missouri Area

Study of RNA editing in Bovine using RNAseq- Contributed to the identification of RNA editing, specifically A-to-I editing, from RNAseq data of different tissues in Bos taurus. - Designed an RNAseq data analysis pipeline that makes use of the best practices to align reads, post process the alignments, gather statistics, call and filter variants.BovineMine - A data warehouse for the Bovine and other ruminant species- Leveraged InterMine, an open-source data warehouse framework, to create a data mining and querying interface which provides users with a portal to investigate genomic annotations, protein annotations, expression profiles, functional annotations and variation datasets.HymenopteraMine - A data warehouse for the Hymenopteran species- HymenopteraMine, in addition to being a data mining and querying interface, enables users to perform cross-species comparison based on orthology.- HymenopteraMine integrates datasets from several ant genomes, bee genomes and wasp.Apollo, a collaborative genome annotation editing tool- Currently working on server side and client side development of Apollo and contributing to adding new features, testing and fixing issues. - Also working on adding the ability to annotate variants and predict the effect of these variants on manually curated gene annotations.

Greater Atlanta Area

Identification of low frequency mutations in Escherichia coli - Identifying mutations in different generations of E. coli as a result of long term experimental evolution. - Making sense of these mutations on a protein interaction based context. - Understanding the role of evolution on these mutations.Identification of residues involved in protein-protein interaction using a sequence based approach. - Identifying residues involved in protein interaction using Direct Covariance Analysis. - Using residue contact information to infer an approximate 3D structure of the resulting protein complex. - Spatial visualization of mutations in these complexes.

Tarrytown, Ny

Identification of meta-gene signatures from gene expression data from two mouse Colitis models.Characterization of correlation of these gene signatures with phenotypic data.Proposing potential therapeutic targets for Colitis and Crohn's Disease.

Atlanta, Georgia

Prediction of structures for key proteins within EF-Tu interaction network in Escherichia coli.Identification of hot-spot residues that are likely to be in the binding interface in a docked complex.Protein-Protein docking to identify the 3D structure of the protein complex.Mapping of newly found mutations in key proteins and study of their effects in the interaction.Study of EF-Tu interaction network to understand what factors affect the evolution of proteins within the network.

Pune, India

Studies on Di-Tertiary-Butyl Phenols as COX-LOX Dual Inhibitors against Human Colon Cancer Cell Lines and Insights into their Cytotoxicity - Generation of ligands for COX and LOX targets - Molecular docking of ligands to COX and LOX to determine a suitable drug candidateMolecular modeling and docking studies on Palladium complex - Molecular modeling of a unique palladium complex - Molecular docking of the palladium complex on human Transglutaminase – 2Novel Xanthene and Amino-Xanthene Derivatives: Synthesis, Molecular docking, Antioxidant and in vivo anti-diabetic activity - Exploring the possibility of xanthene and amino-xanthene derivatives as a drug candidate for diabetes - Molecular docking of such derivatives onto 2 key proteins involved in diabetes: PPARα and PPARγMolecular docking studies on Cyclodextrin and HPBCD as drug delivery systems - Molecular docking of drug into Cyclodextrin and Hydroxy-Propyl-Beta-Cyclodextrin - Observing their behavior and likelihood to serve as a drug delivery system

Pune

Projects involved:Molecular docking and dynamics studies on Human ubiquitin conjugating enzyme Rad6: A Systematic in silico approach - Exploring the possibility of considering human Rad6 as a potential drug candidate for cancer - Ligand library generation - Molecular docking of ligands onto Rad6 - Molecular dynamics of Rad6 to understand its folding behavior and to obtain an equilibrated structureZebra fish Estrogen Receptors (zfERs) α, β1 and β2: Molecular modeling and docking studies with agonist and antagonist - Molecular modeling of Danio rerio Estrogen Receptors - Molecular docking of Cypermethrin and its derivatives on the Estrogen Receptors

Master Of Science - Ms, Bioinformatics

Bachelor'S Degree, Bioinformatics