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I am a scientist with diverse experience in biological research (molecular, developmental, evolutionary, computational), software development, and product management. At Arcadia Science, I am developing software products to enable scientists to build new therapeutics companies by leveraging evolution.
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FounderStealthcoBerkeley, Ca, Us -
ScientistArcadia Science Jul 2022 - PresentBerkeley, California, United StatesProduct leadership for company creation tools- Led product team developing software for company creation- Performed research to generate user stories & requirements for scientific needs- Worked cross-functionally with scientists, engineers, and senior leadership to ensure alignment- Pinch hit on data science, visualization, process development, and strategic eventsDeveloping software for cross-species bioinformatic analyses- Led software development of ProteinCartography, a Python- and Snakemake-based pipeline for searching across the tree of life to build interactive maps of protein structural space- Explored using structural similarity and orthology across species to merge single-cell RNA-seq dataIterated on internal processes for scientific discovery- Designed and implemented processes for starting and managing new research projects -
National Science Foundation Graduate Research FellowUc Berkeley Aug 2015 - Aug 2022Berkeley, California, United StatesAdvisor: Nipam H. PatelExamined the genetic and developmental basis of body plan evolution in crustaceans using CRISPR/Cas9 mutagenesis and functional genomics (ATAC-Seq, RNA-Seq).• Performed bulk Omni-ATAC-Seq to discover cis-regulatory elements genome-wide during a developmental time course of the amphipod crustacean Parhyale hawaiensis (preprint)• Built visualization tools for functional genomic data (ATAC, RNA) to discover clusters of peaks within shared regulatory networks and reveal relationships between accessibility and gene expression• Leveraged deep ATAC-Seq analysis (HINT-ATAC, NucleoATAC) to infer epigenomic landscape of accessible chromatin, including histone occupancy and transcription factor footprinting• Used differential expression and polymorphic allele-specific expression analyses in hybrids of cave and surface Asellus aquaticus embryos to find genes with differential cis- or trans-regulation (paper)• Used bulk short-read (Illumina) and long-read (Nanopore) RNA-Seq to build embryonic transcriptomes for Parhyale and Asellus using diverse assemblers (Trinity, trans-abyss, SOAPdenovo, StringTie2) and generated improved transcriptomes using new Mikado and EvidentialGene pipelines• Led a team with two undergraduate researchers to discover the roles of epigenome-modifying Polycomb and Trithorax Group proteins in Parhyale development using CRISPR-Cas9 mutagenesis perturbations and characterization of complex mutant morphological and gene expression phenotypes• Mentored 11 undergraduates over 7 years; supervised 4 undergraduate honors theses• Authored 3 first-author manuscripts (1 corresponding authorship, 1 review), 1 co-first author paper -
Undergraduate ResearcherHarvard University Sep 2013 - May 2015Cambridge, Massachusetts, United StatesAdvisor: Paola ArlottaWorks on projects centered around elucidating mechanisms of brain regeneration in the axolotl (Ambystoma mexicanum). Performed senior thesis work examining the interface between regeneration and cancer in the axolotl brain. -
Short-Term StudentKyoto University Center For Ips Research And Technology (Cira) Jun 2013 - Aug 2013Assisted with experiments on a project to develop directed differentiation methods for definitive endoderm, one of the first and most critical steps to generating renal, pancreatic, and hepatic tissues.
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Research & Development InternLife Technologies Jun 2012 - Aug 2012Carlsbad, CaWorked on developing transfection methods for human peripheral blood mononucleocytes (PBMCs):- adapted published protocols to isolate PBMCs from fresh human blood- tested a variety of lipid-based transfection methods and electroporation techniques to transfect PBMCs
Dennis Sun Skills
Dennis Sun Education Details
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Molecular And Cell Biology -
Magna Cum Laude
Frequently Asked Questions about Dennis Sun
What company does Dennis Sun work for?
Dennis Sun works for Stealthco
What is Dennis Sun's role at the current company?
Dennis Sun's current role is Founder.
What is Dennis Sun's email address?
Dennis Sun's email address is ds****@****ley.edu
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Dennis Sun's direct phone number is +185835*****
What schools did Dennis Sun attend?
Dennis Sun attended University Of California, Berkeley, Harvard University.
What are some of Dennis Sun's interests?
Dennis Sun has interest in Economic Empowerment, Civil Rights And Social Action, Education, Environment, Poverty Alleviation, Science And Technology, Harvard University, Human Rights, Arts And Culture, Health.
What skills is Dennis Sun known for?
Dennis Sun has skills like Research, Microsoft Office, Graphic Design, Creative Writing, Editing, Publication Design, Adobe Creative Suite.
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Dennis Sun
Stanford, Ca6calpoly.edu, post.harvard.edu, gmail.com, stanford.edu, corn29.stanford.edu, corn14.stanford.edu -
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Dennis Sun
Chicago, Il -
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