Derek Piper Email and Phone Number
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With over 20 years of experience in protein biochemistry and structural biology, I am passionate about applying my expertise to accelerate drug discovery for various therapeutic areas. As the owner of StructuraSense Consulting, I work with biotech and pharma clients to optimize their relationships and experimental strategies with CRO partners, provide expert analysis of delivered structures, design protein constructs based on structural insights, and assist in the plan and design of internal facilities.Previously, I was the Senior Director of Protein Sciences and Structural Biology at Exelixis, where I built and led a team responsible for protein reagent generation and structural biology support for the drug discovery pipeline. I also forged partnerships with CROs and other external facilities to enhance the structural biology capabilities of the company. My skills in group leadership, protein chemistry, and structural biology enabled delivery of high-quality reagents, results, and insights for the projects I was involved in.
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Ceo And Co-OwnerOlympic Protein Technologies May 2024 - PresentSeattle, Washington, United States -
ConsultantStructurasense Consulting Dec 2023 - PresentStructural Biology Consulting• Optimize relationships and experimental strategies with your CRO partners for success• Provide expert analysis of delivered structures • Design protein constructs based on structural analysis• Assist in the plan and design of internal facilities
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Senior Director, Protein Sciences And Structural BiologyExelixis Jun 2022 - Sep 2023Alameda, California, United States• Built protein biochemistry and structural biology capability at Exelixis (recruiting & hiring, lab design, forged partnerships with external facilities)• Led team responsible for protein reagent generation and structure support (X-ray crystallography and cryo-EM) for the Exelixis Drug Discovery pipeline -
Principal Scientist & Asf Molecular Engineeering Site LeadAmgen Aug 2004 - Jun 2022South San Francisco, Ca• Supervised a team of scientists overseeing career development, guiding research plans and mentoring for growth• Lead structural biologist on numerous projects (PCSK9, LCAT, PAC1r, CDK4/6, IL-23 and multiple others), using expertise to accelerate drug development for both small and large molecule targets, and provide insight into target MOA• Solved the structure of the PCSK9 protein alone and in complex with multiple antibody fragments, including the molecule developed into Amgen’s FDA approved PCSK9 inhibitor (Repatha®)• Protein Engineering: utilize protein structures and modeling to engineer amino acid changes into candidate molecules that modulate binding characteristics, improve stability or to use as attachment points for antibody drug conjugates• Named as inventor on numerous granted Amgen patents or patent applications -
Associate Scientist, Structural BiologyTularik May 1999 - Aug 2004South San Francisco, Ca• Expressed, purified, crystallized and solved the structures of multiple proteins and protein/ligand complexes (HCV NC5b RNA polymerase, hepsin, LXR, and multiple others)• Collaborated with medicinal and computational chemists to examine protein/ligand interactions and design modified compounds for synthesis • Antibody Humanization: incorporated human amino acids onto a mouse anti-galanin antibody framework and used structural data to engineer substitutions to improve galanin peptide binding affinity• Maintained lab robotics and X-ray equipment (anode rebuilds, filament changes, beam alignment, etc.), and coordinated installation of Rigaku FR-E diffractometer -
Research TechnicianThe Johns Hopkins University School Of Medicine (Hhmi) Aug 1995 - May 1999Performed independent research in the lab of Dr. Cynthia Wolberger including sub-cloning, expression, purification, crystallization and structural determination of the HoxB1-Pbx1 protein/DNA complex -
Biochemical Research AssociateBioedge Nov 1993 - Aug 1995Developed protein purification methods and performed quality control testing on purified proteins
Derek Piper Skills
Derek Piper Education Details
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Biotechnology -
Biology, General
Frequently Asked Questions about Derek Piper
What company does Derek Piper work for?
Derek Piper works for Olympic Protein Technologies
What is Derek Piper's role at the current company?
Derek Piper's current role is Protein Biochemistry | Protein Engineering | Structural Biology | Protein Crystallography | Large Molecule | Small Molecule | Drug Discovery.
What is Derek Piper's email address?
Derek Piper's email address is de****@****gen.com
What is Derek Piper's direct phone number?
Derek Piper's direct phone number is (732) 667*****
What schools did Derek Piper attend?
Derek Piper attended The Johns Hopkins University, Wheaton College.
What skills is Derek Piper known for?
Derek Piper has skills like Crystallization, Drug Discovery, Protein Chemistry, Biochemistry, Biotechnology, Drug Development, Molecular Biology, Purification, Cell Culture, High Throughput Screening, Protein Engineering, Protein Purification.
Who are Derek Piper's colleagues?
Derek Piper's colleagues are Elham Ettehadieh.
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Derek Piper
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