Devendra Kumar Gupta, Phd Email & Phone Number

Basel, Baselstadt, Ch

Cell biology lead for oncology and obesity related targeted protein stabilization (TPS) PPIs program: Performing, and/or supervising screening and genetic validation studies to validate target-client interaction. Hands-on-experience in development of suite of target engagement and functional cellular assay to support TPS mode of action (MOA) in cells such as HiBit, NanoBit, nanoBRET, induced proximity etc.Project leader for target identification and validation program: Identified novel drug targets from transcriptomic RNAseq data. Expressed and purified protein drug targets, designed and executed in vitro high-throughput biochemical and cellular screens, identified hits and characterized their enzymatic/binding activities in various biochemical/biophysical assays. Designed and supervised chemoproteomics studies to validate cellular target engagement and functional knock out studies to validate the target. Collaborated with cheminformatics, structural biologist and chemist for hit to lead optimization for selected hits with novel chemotypes.

Basel, Baselstadt, Ch

•Developed cell based assays for discovery biology and high-throughput image-based screening assays. •Established in vitro cellular assays for high-throughput small molecule screening. •Worked on several cell-based platforms including iPSCs stem cells, 2D and 3D spheroids models. •Performed RNA sequencing on FACS purified samples and identified novel anti-malarial drug targets. •Expressed and purified protein drug targets, designed and executed in vitro high-throughput biochemical and cellular screens.•Co-led cross-functional collaboration to uncover cellular pathways during malaria liver stage of infection using transcriptomic and proteomics. •Discovered Liver specific protein 2 (LISP2) as a molecular marker of malaria liver stage development and for screening compounds with anti-malarial liver stage activity.

Basel, Baselstadt, Ch

Doctor Of Philosophy (Ph.D.)

Master’S Degree, Biomedical Sciences

Bachelor Of Science (B.Sc.), Biomedical Sciences