Devin Wolfe Ph.D. Email & Phone Number

Basel, Ch

Cambridge, Ma, Us

Paris, France, Fr

Paris, France, Fr

As lead scientist, manage team that evaluates, characterizes, and validates potential therapeutic targets .Focus on multiple approaches to rare diseases, primarily in the neuro and metabolic areas. Establish assays and models for target validation and drive the development of small-molecule screens to advance discovery projects and inform R&D investment/prioritization decisions.- Expedited MOA understanding for Sickle Cell Disease (SCD) program. Devised screening cascade/series of assets to move from development to next stage in 9 months.- As principal for rare, potentially fatal metabolic syndrome, characterized 10-15 mutations and devised high-throughput screening for validation; on track to meet enhanced deadline and advance to next stage in mid-2020

Performed drug screening and development investigations into pharmacological restoration of elevated lysosomal pH—autophagy by extension—in familial Alzheimer’s models. Appointed lead scientist on large-scale study to identify novel lysosomal modulatory compounds with Takeda Pharmaceuticals. Efforts resulted in 3 publications and patent. - Introduced and refined methods for accurate measurement of lysosomal acidification and ionic content. - Developed new study protocols, bioassays, and target validation methods.- Uncovered class of compounds capable of restoring lysosomal acidification in an AD cell model.

Rochester, Ny, Us

Planned/prioritized development and qualification of bioassays to study Btn1p, a S. cerevisiae CLN3 homolog. Managed and developed team, providing strategic oversight to logistics and operations in GLP/GMP environment. Cultivated leadership bench through goal-setting and provided guidance towards advanced academic and industry careers. - Co-authored 5 publications based on cutting-edge research at the intersection of cell biology, molecular, and biochemical approaches.- Published review article in Neuromolecular Medicine emphasizing the importance of yeast in investigation of proteins implicated in channelopathies.- Identified and quantified pH-dependent localization in Btn1p, homolog of human gene CLNE mutated in Juvenile Neuronal Ceroid Lipofuscinoses.

Marlborough, Ma, Us

Conducted medical device research under the guidance of a molecular intervention specialist, and presented findings to other members of the team. Evaluated integrity of implantable coronary stents via SEM analysis, and performed histological analysis of porcine arteries to assess restenosis post-implantation.

Ph.D., Biochemistry

B.S., Biology