Devon Andres, Phd, Dabt Email & Phone Number

Washington Dc-Baltimore Area

Mcs, Jpeo-Cbd, Ft. Detrick, Md 21702

Technical and product management support for the management of advanced development of biologics and other drug candidates for JPM-MCS Chemical Defense Pharmaceuticals. Assist product managers with risk management and cost, schedule and performance monitoring (EVMS based) drug development contracts. Monitor technical progress on IND enabling testing, manufacturing scale up, Animal Rule based efficacy testing, drug safety and clinical trial execution. Provide consultation to clients in the design of experimental studies and protocols, interpretations of experimental results, review of study reports, and recommendations from the Clinical Research Organization (CRO) or other performers. Generate, interpret, and communicate results from in vivo pre-clinical/non-clinical and safety studies to teams of various scientist, program managers, and non-scientists. Review and participate in audits of CRO’s or other performers’ implementation of activities to ensure compliance with GLP practices, standard operating procedures, protocols, and regulation related to FDA, ethics and animal welfare. Involvement in diverse product development teams to include US Government personnel, members of various Federal agencies, Military and Public health officials of US and International partners, and the CRO or other performers, such as statisticians, biologists, toxicologists, clinicians, pharmacologists, and formulation scientists.

Usamricd, Apg, Md 21010

(Early drug-development) Contract support for USAMRICD, Aberdeen Proving Ground, MarylandDuties: Project management and hands-on toxicological studies and assessment of targeted medical countermeasures for alleviation of exposure of chemical agents and toxins of biological as well as drug candidate safety. Projects were product driven with goal of transitioning safe and efficacious drug candidates into advanced development. Main area of research was acute inhalation toxicology of various chemical warfare agents and toxic industrial chemicals i.e. sulfur mustard, phosgene, phosphine, ammonia and nerve agents. Subject matter expert for translational research for in vitro and progressing into in vivo studies as well as assay and cell model development for inhalation toxicology studies, to include direct and air/liquid interface exposures using Vitrocell exposure system. In vivo studies for small animal models, various routes of therapeutic administration and agent exposures to include, im, ip and subcutaneous methods as well as various aerosol, vapor and gas inhalation exposure systems for whole-body, head/nose-only and direct airway exposure to chemical agents. Research involved biochemical, pathophysiological and toxicological components, e.g. receptor binding studies, whole body plethysmography, histopathology and studying cardiorespiratory in exposed mice and rats. Responsibilities also included for writing grants proposals, animal use protocols, SOPS, technical reports for internal and external program managers and non-scientists, and preparation of manuscripts for peer-reviewed journals and annual and final reports.

Usamricd, Apg, Md 21010

(Early drug-development)Contract support for USAMRICD, Aberdeen Proving Ground, MarylandDuties: Project management and hands-on toxicological studies and assessment of targeted medical countermeasures for alleviation of exposure of chemical agents and toxins of biological as well as drug candidate safety. Projects were product driven with goal of transitioning safe and efficacious drug candidates into advanced development. Main area of research was acute inhalation toxicology of various chemical warfare agents and toxic industrial chemicals i.e. sulfur mustard, phosgene, phosphine, ammonia and nerve agents. Subject matter expert for translational research for in vitro and progressing into in vivo studies as well as assay and cell model development for inhalation toxicology studies, to include direct and air/liquid interface exposures using Vitrocell exposure system. In vivo studies for small animal models, various routes of therapeutic administration and agent exposures to include, im, ip and subcutaneous methods as well as various aerosol, vapor and gas inhalation exposure systems for whole-body, head/nose-only and direct airway exposure to chemical agents. Research involved biochemical, pathophysiological and toxicological components, e.g. receptor binding studies, whole body plethysmography, histopathology and studying cardiorespiratory in exposed mice and rats. Responsibilities also included for writing grants proposals, animal use protocols, SOPS, technical reports for internal and external program managers and non-scientists, and preparation of manuscripts for peer-reviewed journals and annual and final reports.

Usamricd, Apg, Md

(Early drug development)Contract support for USAMRICD, Aberdeen Proving Ground, Maryland Designed and conducted non-clinical studies for development and assessment of medical countermeasures to alleviate exposure to chemical warfare agents, other agents of interest and toxic industrial chemicals, e.g., sulfur mustard, phosgene, phosphine, ammonia, nerve agents, and botulinum toxin. These studies included model and method development for both in vitro and in vivo studies. Performed biochemical, pathophysiological and toxicological studies as well as survival surgery for implantation of telemetry devices to study cardiorespiratory and CNS parameters in exposed guinea pigs, as well as therapeutic drug safety. Responsible for grant proposals and project management to include budgets, animal use protocols, SOPS, technical reports for internal and external program managers and non-scientists, and preparation of manuscripts for peer-reviewed journals. Provided advice, counsel, and/or instruction on work and technical matters as well as supervising/mentoring high school, college apprenticeships, and laboratory technicians.

Aberdeen Proving Ground

Responsible for designing and conducting non-clinical studies for development and assessment of medical countermeasures to alleviate exposure to chemical warfare agents, toxins of biological origin and toxic industrial chemicals, e.g., sulfur mustard, phosgene and botulinum toxin. Evaluated short peptide inhibitors to counteract botulinum neurotoxin (BoNTA) poisoning in vitro. Model and method development for both in vitro and in vivo studies primarily in the respiratory program area for sulfur mustard. Responsibilities also included writing grants proposals, SOPS, technical reports for internal and external program managers and non-scientists, preparation of manuscripts for peer-reviewed journals and presentation of research at conferences and meetings. Supervised/mentored high school, college apprenticeships, and laboratory technicians.

1) Doctoral Research (June 2000 –Dec 2006): Research emphasis in immunochemistry. Performed various studies to understand glucocorticoid-induced immunosuppression of natural killer cells and cytotoxic T lymphocytes. Maintained and treated human cell lines and lymphocytes isolated from human blood, immunoassays, enzymatic assays and other molecular biological assays involving natural killer cells and T cells, their functions, and mechanisms of regulation of certain proteins.2) Radiation Safety Assistant (September 2003 December 2004): Weekly swipe tests, collected radioactive waste, assisted with quarterly audits. 3) Graduate Assistant for General Chemistry Labs (September 1999 December 2001): Lab supervision, explanation and guidance of weekly labs, grading lab reports, tutoring.

1) Adjunct Professor (July September 2004): Taught and managed general chemistry lab classes. 2) Chemistry workshop instructor (March June 2002): Prepared worksheets, instructed and helped students with general chemistry

Quality control testing of raw materials, in-process and final products following good manufacturing practices (GMP) for specialty polymers and coatings.

Research and development of new assays, mainly utilizing gel-filled capillary electrophoresis, to improve accuracy and efficiency for the quality control of certain pharmaceutical products, validating current quality control protocols and under good laboratory practices (GLP) guidelines..

Preparation of lab and reagent, and performed thermodynamic experiments using batch calorimetry.

Degree: Doctor, Biomedical Sciences

Semester Hours: 100 Description: Doctoral Dissertation: Further Molecular Characterization of the Effects of Glucocorticoids on Granzyme.

Graduate Certificate, Forensic Toxicology, 4.0

Medical Technology

Semester Hours: 13 Description: Quest Student Classes taken to improve on knowledge and selectiablity while deciding on participating.

Degree: Bachelor Of Science, Biomedical Sciences

Minor: Chemistry, Mathematics; GPA: 3.1 Description: Graduated from the Lee Honors College Honors Thesis: SDS Non-Acrylamide Polymeric.