Devon Chandler-Brown Email & Phone Number

Menlo Park, California, Us

Menlo Park, California, Us

- Led the effort to build and launch a 3-gene combined single-gene NIPT. My work improved assay sensitivity; created a novel, extensible calling algorithm; and moved from manual effort to an automated process for most steps allowing for scaling to 10x the number of samples.- Identified a new short read sequencing platform that saved over $1M/year including available option research, performance testing, and preliminary price negotiation.

Menlo Park, California, Us

- Invented a method of measuring aneuploidy in cfDNA using capillary electrophoresis at <0.9% CV. Optimized measurement approaches, multiplex PCR capture chemistry, and data processing algorithms to minimize noise.- Led the design, testing, development, and launch of a novel EUA COVID-19 molecular test that sold 600k tests. Coordinated manufacturing with an external partner and served as technical sales support. Implemented internal testing for monitoring of employees.

Stanford, Ca, Us

-Developed flow cytometry as a tool to measure the size-dependence of RNA expression genome-wide by RNA-seq-Investigated the molecular determinants of size-independent gene expression using targeted mutagenesis and live-cell microscopy

Stanford, Ca, Us

-Designed and completed research projects investigating the role of cell size in shaping cell physiology including cell cycle dynamics and gene expression control-Identified the cell-size-dependence of budding yeast proteins by developing a novel computational pipeline to analyze genome-wide flow cytometry screens of yeast proteins-Developed a stochastic computational simulation for size control in budding yeast using quantitative time-lapse fluorescent microscopy to measure key rates; showed that cell size control arises from separate mechanisms in each cell cycle phase, rather than a single regulatory mechanism during the whole cell cycle-Measured the genomic architecture of budding yeast at the genomic scale using Hi-C; tested the role of nuclear position on gene expression timing by transplanting transcriptional reporters across the genome-Mentored undergraduate and graduate students in molecular biology techniques, computational data analysis, and experimental design

Stanford, Ca, Us

Course: Explorations in Stem Cell Biology (BIO 168)Helped develop course material for senior undergraduate seminar in stem cell biology; provided feedback on students' scientific writing; guided students as they developed and presented research proposals

Stanford, Ca, Us

Course: Core Molecular Biology Lab (Stanford BIO 44X) Instructed students in experimental design, molecular biology techniques, and data analysis/interpretation; critiqued scientific writing and data presentation; provided weekly office hours for students to ask questions

Bethesda, Md, Us

• Characterized the effect of GTPase signaling on 3D cell migration to identify the molecular pathwaysthat are disrupted in DOCK8-deficiency syndrome using live-cell microscopy.• Identified the cell type distributions and activation kinetics in immune cells from patients withpreviously uncharacterized immunodeficiencies

Seattle, Wa, Us

• Examined the molecular basis of aging using C. elegans and budding yeast as a model systems• Determined the mechanism underlying the influence of osmotic stress on longevity in C. elegans• Tested the effects of protein translation on aging phenotypes and demonstrated the formation of a toxic derivative of a longevity-promoting compound

Doctor Of Philosophy - Phd, Cell/Cellular And Molecular Biology

Bachelor Of Science - Bs, Biochemistry And Molecular Biology