Dhruv Patel, Ph.D. Email & Phone Number

White Plains, New York, Us

As a Scientist at Oligomerix, Inc., I utilize my excellent laboratory skills and a strong background in neurobiochemistry and neuropharmacology to jump start and lead a small preclinical in vivo research team in an incubator lab located at Albert Einstein College of Medicine, Bronx, NY. The primary duties involve designing and executing invivo experiments for projects focused on validating and characterizing the preventive and therapeutic effect of selected drug candidates in various mice models of Alzheimer’s disease and related tauopathies. In addition, I routinely engage in internal and external collaborative efforts to move forward the ongoing projects and in process acquire an extensive experience in various aspects of preclinical drug discovery and development.

White Plains, New York, Us

At Oligomerix, I lead and assisted several preclinical in vivo projects that are targeted towards characterizing and validating small molecules and biomarkers specific for tau fragments to accelerate our efforts in developing a small molecule inhibitor of tau self-association, an initial step of tau aggregation cascade that progresses to devastating neurodegeneration.Present job responsibilities:Designed and executed preclinical research plans integrating both disease and pathway approaches to support the company's small molecule program. Identified and utilized relevant invitro and invivo models to develop methods evaluating the biomarkers and mechanism of action of company’s lead drug candidates. Proposed and executed biomarker strategies for target engagement, and pharmacodynamic endpoints of the company's lead drug candidate. Oversaw and worked closely with research associates to manage the execution of their assigned research task.Performed detailed research data analyses and reporting of study readouts both internally and at scientific conferences.

Chicago, Il, Us

Developed and characterized transgenic animal models of Alzheimer's disease (AD) that help discern the neuro-protective role of nuclear receptor protein in AD based dementia.Conducted preclinical studies to evaluate motor functions in a mouse model of Parkinson's disease developed using cre lox system.Identified and repurposed the known FDA approved drugs as potential therapeutic candidate for treating cognitive impairment using transgenic animal models of AD. Acquired extensive experience in mouse genetics, in vivo rodent models, rodent organ dissections & molecular biology and SOFTWARES such as - Noldus software, PRISM graph pad, Genomatix software suite for transcription factor binding analysis, MS office (Word, excel, powerpoint) and Adobe Photoshop

Nj, Us

Tutoring Services at Hudson County Community College is a centrally organized program which coordinates free, drop-in, peer tutoring in many subject areas and centers on main campus. All tutoring is free to currently enrolled Lane students and provides one-on-one assistance in most academic subjects.My role as Cellular and Molecular Biology Tutor was to serve students enrolled in credit courses related to cell biology,human anatomy and physiology I & II, nutritional sciences and chemistry, by providing supportive learning environments, instilling confidence, encouraging independence as learners, and providing individual peer tutorial assistance and academic support.

Queens, Ny, Us

Prepared recombinant plasmid DNA for target identification research and carried out experiments in yeast molecular biology. Mastered hands on experience in techniques that include, but are not limited to: gel electrophoresis, real time PCR, RT-PCR, immunoblotting, confocal microscopy, and transformation of bacterial and yeast cells.

Tarrytown, New York, Us

During my tenure at Regeneron Bio Pharmaceuticals Inc, Tarry town NY assisted the Staff Scientist to investigate the role and activity of potential targets against metabolic disorders like Diabetes, hyperlipidemia and cardio vascular diseases.Identified and validated new targets for Obesity and Metabolic Disease group.Implemented and populated a repository for molecular biology reagents that include, plasmid clones, maxipreps and glycerol stocks of DNA clones and sequencing primers.Expedite the tracking for every reagent by creating excel based database which also contained relevant information for each of the reagent. Manufactured plasmid clones and viral clones and optimized the screening of positive clones through restriction digestion analysis and DNA sequencing.Amplified cloned plasmid DNA through bacterial transformation and performed high throughput DNA isolation using Vacuum manifold protocol and 96well format DNA isolation. Analyzed protein expression and activity of the clones, through immunochemical assays like SDS PAGE and western blotting.Characterized antibodies and used them in developing functional cell based assays to screen activity and localization for new targets.

Worked in Research, Development and Quality Assurance Department, performed pre clinical, Pre-formulation and Dissolution studies. Underwent extensive training on various aspects of Quality Compliance, Regulatory and Clinical Practices (FDA, ICH) required to produce an effective, safe, compliant and ready- to- market product. Assisted in preparing and reviewing, quality plans (GMP, GLP),validation protocol (SOP) and auditing procedures.

Doctor Of Philosophy (Ph.D.), Biochemistry (Neuro Track)

Associate'S Degree In Management (Few Credits Remaining)

Master'S Degree In Biological And Pharmaceutical Biotechnology

Bachelor'S Degree In Pharmaceutical Sciences