Diana Gesto Email & Phone Number

Mannheim, Bw, De

Mannheim, Baden-Württemberg, Germany

Mannheim, Baden-Württemberg, Germany

- Provide specialized scientific and technological support to customers

Faculdade De Ciências E Tecnologia Da Universidade Nova De Lisboa

- Applied computational and bioinformatics methods in the research projects being developed in the lab;- Used the Caver Analyst software to study probable tunnels in the enzyme formate dehydrogenase, which could carry the substrate and products from the solvent to the active site and vice-versa;- Learned how to build phylogenetic trees, based on the sequence of known proteins, in order to study protein evolution;-Responsible for the supervision of bachelor students;- Responsible for the literature review on the subject;- Responsible for the writing and preparation of the article for publication on a peer-review scientific journal;- Responsible for the writing and submission of research grant applications.

Faculdade De Ciências Da Universidade Do Porto

- Continued some of the research I started during my Ph.D., on the enzyme fatty acid synthase;- Studied the reaction mechanism of one of its modules using QM/MM methods;- Performed molecular dynamics and docking on this enzyme, in order to discover the best position of the substrate on the active site;- Responsible for the supervision of two bachelor students and one master student.- Responsible for the literature review on the subject;- Responsible for the writing and preparation of the article for publication on a peer-review scientific journal;- Responsible for the writing and submission of research grant applications.

Universidade Do Porto

- Collaborated on the development of the platform Balcão U.Norte.pt;- Collaborated on the development of the new website for the University of Porto;- Responsible for the translation (Portuguese-English) and proof-reading of several documents;- Responsible for the planning and writing of research projects.

Faculdade De Ciências Da Universidade Do Porto

- Studied the reaction mechanism of the ketoacyl synthase module of fatty acid synthase using QM/MM methods;- Supervised undergraduate and graduate students;- Responsible for the writing and submission of research grant applications.

Faculdade De Ciências Da Universidade Do Porto

- Studied the enzyme HMG-CoA Reductase, which is involved in the synthesis of cholesterol;- Performed computational alanine scanning mutagenesis on this enzyme to find which of the residues of the interface were the ones that contributed the most to the formation and stabilization of the tetramer;- Learned and performed molecular dynamics, protein-protein interactions, and docking;- Worked on other smaller projects, such as the study of the reaction mechanism of some of the modules that compose the enzyme fatty acid synthase;- Mastered important techniques such as molecular modeling, molecular dynamics simulations, QM/MM, computational alanine scanning mutagenesis, protein-ligand docking, and protein-protein docking;- Responsible for the literature review on the subject;- Responsible for the writing and preparation of the article for publication on a peer-review scientific journal.

Cosenza Area, Italy

- Studied the reaction mechanism of the enzyme serine hydrolase using the ONIOM method;- Employed QM/MM, MM/MM, and QM methods;- Responsible for the literature review on the subject.

Faculdade De Ciências Da Universidade Do Porto

- Worked on a project denominated "Application of Computational Quantum Chemistry on Biological Systems";- Performed computer simulations using techniques such as Molecular Dynamics and QM/MM (ONIOM) applied to different enzymes.

Faculdade De Ciências Da Universidade Do Porto

- Studied the reaction mechanism of the enzyme L-asparaginase II, which has applications in both cancer therapy and food industry;- Used QM/QM methods (ONIOM) to discover the catalytic mechanism of the enzyme and characterize it in terms of energy and structure;- Responsible for the literature review on the subject;- Responsible for the writing and preparation of the article for publication on a peer-review scientific journal.

Doctor Of Philosophy - Phd, Theoretical Chemistry

Activities and Societies: - Organizing committee of the following events: European Master in Theoretical Chemistry and Computational.

Master Of Science - Ms, Biochemistry, 17 (Out Of 20)

Activities and Societies: - Poster presentation at 2o Encontro Nacional de Química Terapêutica - Poster presentation at IJUP 2010 - 3rd.

Bachelor’S Degree, Biochemistry, 15 (Out Of 20)

Cellular Biology, Pure Chemistry, Linear Algebra, Molecular Biology, Physical Chemistry, Analytical Chemistry, Organic Chemistry.

High School, Science And Technology, 17 (Out Of 20)