Diane Heiser Email & Phone Number

Downingtown, PA, US

Wilmington, DE, US

Wilmington, DE, US

Prelude Therapeutics is a clinical-stage precision oncology company focused on discovering and developing small molecule therapies optimized to target the key drivers of cancer cell growth, resistance, and survival. - Led translational efforts through a Series C raise and successful IPO- Leads precision medicine and translational research efforts for.

Redwood City, CA, US

Consultant on platform development for several biotechnology startups focused on integration of machine learning / AI with biology and robotics to improve translational research, drug discovery and therapeutics development. Novel technology platforms focused across areas including aging, antibody therapeutics, immune modulation, and high-throughput nascent.

Foster City, California, US

• Identified, recruited and led team of scientists leveraging Notable’s platform for precision medicine in areas of high unmet need, including patient stratification, combination therapy discovery and mechanism of action.
• Drove key biotech and pharma partnerships resulting in novel mechanism of action insights, biomarker discovery, and data packages influencing the design and progression of clinical trials for partner assets
• Responsible for all internal scientific research programs - communication of milestones, allocation of resources, budget management, and interdisciplinary program management using Agile workflow
• Built and managed teams of 15+, including research & development, high-throughput screening and CLIA lab groups
• Led cross-functional effort to build data analysis pipeline leveraging machine learning, custom software, and a worldwide remote analytical team. Designed automated quality control system and report generation in.
• Designed and led 2 novel drug discovery programs, resulting in 3 patent submissions and a clinical trial partnership

Palo Alto, CA, US

• Laboratory of Dr. Michael ClarkeInstitute for Stem Cell Biology and Regenerative Medicine
• Engineered novel genetic cassettes to stably bypass microRNA machinery in order to study the role of microRNA in neural and hematopoietic stem cell development and maintenance
• Supervised laboratory technicians generating CRISPR-targeted knockouts of DGCR8 in human breast and colorectal cancer xenografts to determine the role of microRNA in cancers
• Mentored MD/PhD student in developing neural and hematopoietic stem cell models of Down Syndrome to determine the role of reactive oxygen species in the pathogenesis of disease and a potential connection to USP16
• Received interdisciplinary Bio-X research grant to mentor undergraduate student
• Authored research sections of R01 and P01 grant submissions

21201, MD, US

• Department of Pediatrics, Laboratory of Dr. Curt Civin
• Analyzed expression of microRNA and mRNA in rare populations of murine hematopoeitic stem and progenitor cells (work published in PLOS One)
• Studied functional role of microRNA in hematopoietic stem cell maintenance and myeloid differentiation using in vivo models of microRNA overexpression and knockdown
• Characterized loss of microRNA phenotype in the hematopoietic system by tissue/lineage-specific DGCR8 knockout

Postdoc

Doctor Of Philosophy (Phd), Cellular & Molecular Medicine

Bachelor'S Degree, Molecular Biology