I pursue research at the forefront of physics and quantitative biology with emphasis on mathematical modelling and analysis of biological data, development of computational methods, systems biology, biophysics, and biomathematics. I develop and apply predictive models for biological and biophysical systems and their interactions at multiple scales, and create statistical methods for the analysis of the complex correlated data. I am actively engaged in joint projects with experimental biologists and physicists producing such data.Much of my current research is directed at combining genomic sequence and expression level information with structural information to develop models to predict biological function. My efforts have focused on the development and application of biophysical and bioinformatics methods aimed at understanding the structural and energetic origins of chromosome interactions to reveal the underlying physical folding principles. My work includes fundamental theoretical research and applications to problems of biological importance as well as the development of appropriate software.