Dinesh Chandra Email & Phone Number

New Brunswick, Nj, Us

 Lead a cross functional team of scientists responsible for oncology deliverables from early concept to clinical introduction (Small molecules, biologics, and RNAs/LNP) Lead new target identification, validation, due diligence and portfolio entry Manage outsourced studies with CROs and mange academic & industry alliances  Build a new discovery research team and establish an oncology/immunology lab to support therapeutic discovery/translational programs at Lung cancer initiative (LCI)

Cambridge, Cambridgeshire, Gb

 Led a cross functional team of scientists responsible for Immuno-oncology deliverablesfrom target discovery through clinical introduction (Discovery biology Lead) Investigated novel therapeutic concepts for the Oncology that enable candidate selection Investigated/validated new targets that activate innate immune response of tumor andmyeloid cells in tumor microenvironments Developed in vitro assays to investigate mechanism of immunotherapy resistance incancer patients and developed concept for combination therapies Led small molecule- immune-oncology (IO) new target forum and led new targetselection/ portfolio entry

Nutley, Nj, Us

 Led a matrix team, partnered with different internal functions (including discovery biology, in vivo pharmacology, DMPK, bioinformatics scientist, clinical development team) and external functions (CROs) to coordinate the execution of IND enabling translational research Planned and executed lead optimization, GLP equivalent /non-GLP- in vitro/ in vivo pharmacology and biomarker development studies for clinical/ pre-clinical programs Studied mechanism of radiation combination therapies with small molecule IO drugs+CPI and performed proof of principle in vivo efficacy/combination studies  Developed and validated immunoassays for immuno-oncology targets, to identify PD biomarkers (PK/PD relationship), Immunotoxicity/ indication/ patient selection biomarkers, transcriptomic and proteomic analysis (multi-color flow cytometry, MSD, CBA, Luminex, qPCR, RT-qPCR, nanostring and RNAseq) and worked with clinical TM leads to develop clinical biomarker plans Planned and executed in vivo pharmacology and biomarker development studies for clinical/ pre-clinical programs

Bronx, New York, Us

 Executed preclinical (in-vitro and in-vivo pharmacology) laboratory research plans tosupport translational immuno-oncology projects Developed combined therapies using immune modulators (small molecules) to improveanti-tumor T cell responses with cryoablation for treatment of solid tumors Studied immunosuppressive mechanisms in the tumor microenvironment and developedtherapies targeting myeloid derived suppressor cells (MDSC) and tumor associatedmacrophages (TAM) Investigated mechanism of innate immunity activation of tumor and myeloid cells intumor microenvironments Developed radioactive phosphorus (P32) labeled Listeria (p32-Listeria) for treatment of cancer and performed proof of principle in vivo efficacy/combination studies

Bronx, New York, Us

 Studied anticancer mechanism of stimulator of interferon genes (STING) agonist c-di-GMP Conducted/ developed in vitro immunology assays using primary human blood cells fromcancer patients and dissociated tumor cells/spheroids culture assays Routinely Planed and performed tumor immunology, in vivo pharmacology andbiomarker development experiments using mouse models (syngeneic and geneticallyengineered/transgenic mouse models for oncology) Developed 188Rhenium labeled Listeria (radioactive Listeria) for treatment of cancer and performed proof of principle in vivo efficacy/combination studies  Developed combined anti-cancer therapies and conducted proof of mechanism (POM)studies for onco-immunology Performed immune phenotyping of murine and human immune populations (e.g. cellsorting, multicolor flow cytometry) and functional assessment of immune subsets instandard immunological assays and techniques (e.g. T/NK- cell assays, TAA specificCTL assay, ELISpot, apoptosis, cytokine/chemokine measurement) Mentored trainee and graduate students for immunology research projects

New York, Ny, Us

 Studied of innate immune responses/ signaling of early secretary proteins of M.tuberculosis (M. tb) and mechanism of M. tb dissemination from lung to other organsusing in vitro human lung model Performed study/experiment design, human immunology assay development, execution,peptide mapping and ligand binding assays Mentored graduate students, international trainees and summer students for immunologyresearch

Phd, Immunology

M.Sc, Microbiology And Molecular Biology

Bachelor'S Degree, Biology/Biological Sciences, General