Dipesh Budhathoki Email & Phone Number

Philadelphia, Pa, Us

Queens, Ny

• Accomplished 11-step (multistep) synthesis of functionalized Gal β (1,4) Man Phosphate vaccine candidate optimized for antibody conjugation against the Leishmania parasite.• Synthesized and purified over 50 small molecules from chemistry reaction crude mixtures (mg – g) in a project involving Leishmania parasite using various chromatography techniques including normal phase chromatography, reverse phase chromatography (using prep HPLC), ion exchange chromatography (IC),• Prepared and analyzed over 50 samples using High-performance liquid chromatography (HPLC), gas chromatography (GC), liquid chromatography-mass spectrometry (LC-MS), NMR (1D and 2D) and FTIR. Analyzed and interpreted data, achieving 98% accuracy in identifying compounds and optimizing product formulations.• Independently conducted operation and maintenance of flash chromatography and other lab equipment, interfaced with instrument vendors for repairs, and ensured timely resolution to maintain optimal operational efficiency.• Utilized Waters Empower and Masslynx software for data acquisition and analysis effectively.• Demonstrated strong multi-tasking abilities by managing 3 projects simultaneously with priorities, maintaining high-quality standards and meeting all project deadlines.• Authored detailed technical reports and standard operating procedures (SOPs) while maintaining electronic laboratory notebooks and records to ensure precise and accurate documentation.• Worked effectively as a team player in a multidisciplinary team of chemists, biologists, pharmacologists, and formulation scientists to conduct virus-like particle (VLP) immunological study of O-glycoside and phospho-glycoside derivatives for the GalMan vaccine candidate

New York, United States

• Developed and prepared lab samples for biomedical laboratories to conduct experiments.• Monitored inventory levels, ordered supplies as needed, and ensured timely delivery of active pharmaceutical ingredients and excipients for teaching labs.• Trained over 100 biomedical science students on various analytical instruments, including UV spectrophotometry, TLC, column chromatography, HPLC, and centrifuge, resulting in a 95% success rate on laboratory experiments.

Kathmandu District, Nepal

• Conducted quality control study of raw materials and finished product to ensure their compliance with GMP.• Conducted friability and hardness physical tests for finished products.• Conducted assays for determining the content of active pharmaceutical ingredient in the final finished product.• Prepared test reports and submission to quality assurance department.

Doctor Of Philosophy, Medicinal Chemistry, Pharmaceutical Science, 3.9

Master Of Science (Ms), Pharmaceutical Sciences, 3.78 / 4

Thesis title "Molecular docking and simulation studies: in silico design"

Bachelor Of Pharmacy (B.Pharm.), Pharmacology

Activities and Societies: Registered Pharmacist under Nepal Pharmacy Council